Part 1 Community Tips

Name of community
Kelin Literary Garden -- "one-stop" student community of Sun Yat-sen University North Campus
Community Location
3rd Floor, Block A (31st floor), Graduate Building, North Campus
Configuration of functions
The second classroom activity space is equipped with reading space, moral and art space, caucus activity space, academic study space and other rich space, aiming to provide teachers and students in North Campus with a variety of venue services such as caucus construction, academic discussion, teachers and students exchange, leisure reading and so on.

In order to ensure the efficient use of community resources, students can apply for the activity room on demand through the enterprise wechat workbench. During the use, students should abide by the "Sun Yat-sen University" "one-stop" Student Community Use Convention "to jointly maintain the safety of the public environment and facilities.

Part 2 Booking Guide
 

① Open the enterprise wechat workbench
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② Choose the "one-stop" student activity room for reservation

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③ Fill out the application form and select the activity room. The staff will review and approve the application within three working days after the application is submitted

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④ On the day of the activity, show the application for appointment approval to the 303 duty staff for check-in and registration 

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⑤ After the end of use, organize the materials in the activity room, clean and take away personal belongings, and check out and register in the 303 duty room.

(Check in and check out registration form)

Part 3 Community Mini-Map

· Community distribution

· Activity room can be reserved

· Integrated space: where the logo of Kelin Bookstore is located

· Reading space:

(Reading space 318)

(Reading space 319)

(Reading space 320)

(Reading space 323)

(Reading space 324)

(Reading space 325)
 

· Moral and Artistic Space 1 -- Multi-function hall

(Multi-function Room 306-307)

· Moral and Artistic Space 2 -- Music room

(Music Room 310)

(Music Room 312)

(Music Room 314)

(Music Room 317)

· Moral and Artistic Space 3 -- Dance studio

(Dance Studio 321-322)

(Dance Studio 326-327)
 

· Caucus activity space: 311

· Academic study space: 301-302

Dear students, 

Kelin Literary Garden is looking forward to your arrival! 

Whether it is academic discussion or party group activities, 

the library has set up an activity field for you. 

We hope that through this dynamic and creative space, 

we can bring you more wonderful experiences and beautiful memories. 

Don't hesitate! Make an appointment now! 

We look forward to seeing you here!

( Original link: "ZhongShan School of Medicine" public account: https://mp.weixin.qq.com/s/8uaCreb8urkhW6Dt3aYm4w )

    Recently, the Guangdong Provincial Association for Science and Technology and the Provincial Department of Science and Technology issued a notice on the naming of the "Guangdong Provincial Science Education Base" (2025-2029), and 333 units were rated as Guangdong Provincial Science Education Base after expert review and publicity.

Profound academic background: the frontier of stem cell and regenerative medicine research

    The Stem Cell and Regenerative Medicine Popular Science Base is built on the key laboratory of stem cells and tissue engineering at Sun Yat-sen University. Since the 18th National Congress of the Communist Party, General Secretary Xi Jinping has attached great importance to popular science work, emphasizing that "scientific popularization should be placed on an equal footing with technological innovation." To promote the dual development of popular science and technological innovation, the team is actively establishing the Stem Cell and Regenerative Medicine Popular Science Base, using the facilities of the key laboratory of stem cells and tissue engineering, its website, and the "MSC Vanguard" public account as the main platforms for popular science promotion. The laboratory has gathered 27 top research talents, including many national and provincial talent award winners, such as recipients of the National Outstanding Youth Fund. The team has published over 250 papers in internationally renowned journals such as Nature and Cell Stem Cell, and has undertaken more than 200 national and provincial research projects. It has a human stem cell bank, a primate experimental platform, and a GMP-standard stem cell production base, supporting our university's approval of five nationally registered stem cell clinical research institutions, with complete research facilities and systems, providing a solid backing for the popular science work in stem cells and regenerative medicine.

Fig: Group photo of members of the Key Laboratory of the Ministry of Education

Fig: MSC Wonder Soldier official account

Rich popular science content: a panoramic presentation from basic research to clinical application

    The base has a science popularization team composed of more than 10 core members, focusing on transforming the complex knowledge of stem cells and regenerative medicine into easy-to-understand content, from the origin and characteristics of stem cells to the cutting-edge progress of clinical application, showing the charm of this field in an all-round way. The team released more than 80 popular science pushes related to stem cell therapy through the "MSC Wonder" official account, with a total of more than 60,000 views, more than 3,000 followers, and organized a number of offline interactions to gain an in-depth understanding of the audience's popular science needs.

    Through the regular "Stem Cell Laboratory Open Day" on the National Science Popularization Day, the summer camp for college students, and the general education course of "Stem Cell and Regenerative Medicine", the science popularization is carried out for medical and undergraduate students of the whole university, so that students can experience the scientific research atmosphere and scientific research facilities of the laboratory, understand the latest developments of stem cell research, and stimulate their enthusiasm for participating in stem cell scientific research. In cooperation with the Guangdong Provincial Medical Association, provincial academic lectures such as the "Academic Express" (Gaozhou and Shenzhen) and the Cell Therapy Society were held, attracting more than 2,000 medical workers and researchers from grassroots hospitals. Recently, the team has strengthened popular science, and the popular science account of "Popular Science China" has attracted the attention and messages of fans all over the country as soon as it was launched, and also made the team more aware of the needs of the masses for stem cell science popularization. 

Fig: Group photo of members of the popular science team

Popular science to the future
    Stem cell and regenerative medicine is an important development direction of medicine in the future, which is expected to bring new hope for mankind to cure end-stage diseases. At the beginning of the year, the country has approved the first stem cell drug in China, and stem cell therapy has once again become the focus of heated public discussion. The Stem Cell and Regenerative Medicine Science Popularization Base was awarded the Guangdong Provincial Science Education Base, which not only inspired the team's belief in strengthening the construction of science popularization, but also helped to better inform the public of stem cell science knowledge. In the future, the Stem Cell and Regenerative Medicine Science Popularization Base will continue to shoulder the important task of disseminating scientific knowledge and improving the scientific quality of the whole people, expand the entity of the science popularization base, enhance the interactive experience, create a comprehensive stem cell science popularization platform, and actively carry out research and science popularization activities for primary and secondary school students and the general public. We believe that the base will not only promote the public's understanding of stem cells and regenerative medicine, dispel the misunderstanding of cell therapy, but also look forward to inspiring more teenagers and college students to devote themselves to stem cell and regenerative medicine scientific research, and inject new vitality into China's scientific and technological development.

Eukaryotic pre-mRNA can be selectively processed to form different RNA isomers, which include variable splicing and variable caudation. In addition, the same gene also has variable promoters, thus producing RNA isomers with different 5 'ends. These types of complex RNA isomers are widespread in mammalian cells. However, it is not clear whether m6A can selectively label these RNA isomers, especially whether the same m6A site on different RNA isomers can also produce different m6A modifications. The lack of understanding of this scientific problem is mainly due to a lack of technology. Because existing m6A detection techniques require interruption of RNA, and second-generation high-throughput sequencing can only read short sequences, it is difficult to distinguish m6A on different isomers. Oxford nanopore sequencing (ONT), a third-generation sequencing technology, can detect m6A modifications using direct RNA sequencing (DRS) to directly read changes in the current of full-length RNA passing through the nanopore. However, the nanopore reads the electrical signals of multiple bases at once, and the detection of m6A by electrical signals relies on deep learning models. Due to the lack of large-scale m6A positive signal at the single molecule level, although the current deep learning model can accurately identify the m6A site, it is difficult to reach the resolution at the single molecule level, and it is still unable to accurately distinguish the m6A modification state on different isomers.

On February 7, 2025, Wang Jinkai's research group at the Sun Yat-sen School of Medicine at Sun Yat-sen University published an online study entitled "Single-molecule m6A detection empowered by endogenous labeling unveils" in the journal Molecular Cell complexities across RNA isoforms ". In this paper, APOBEC1-YTH was used to generate C-to-U mutations near m6A of endogenous RNA in cells, and the third generation of Oxford nanopore direct RNA sequencing (ONT DRS) was performed, so that m6A could be endogenous labeled at the single-molecule level by C-to-U mutations of 10-100 nt near the known m6A site. After data cleaning through semi-supervised learning, m6A electrical signals of about 1 million single molecule level 5-mer were obtained, and a deep learning model m6Aiso was trained to accurately detect m6A modifications at the single molecule level. This revealed that the same m6A site can also produce extensive differences in different isomers through at least three different mechanisms. Especially in the epithelial-stromal transformation model, after TGF-β induction, the activated transcription factor SMAD3 selectively promotes m6A modification of downstream RNA with SMAD3 as promoter by recruiting METTL3/METTL14/WTAP, resulting in selective m6A up-regulation of the same gene using isomers of different promoters. This study provides a new perspective for understanding the complexity of m6A in isomers and the selective regulation mechanism of m6A.

The corresponding author of the paper is Wang Jinkai, professor of Sun Yat-sen School of Medicine, Sun Yat-sen University. Guo Wenbing, Ren Zhijun and Huang Xiang, postdoctoral fellows of the research group, are co-first authors of the paper. This work was supported by the National Natural Science Foundation of China, the Science Foundation of Guangdong Province, the Postdoctoral Fund and the Interdisciplinary Team project of Sun Yat-sen University.

Original link:

https://www.cell.com/molecular-cell/abstract/S1097-2765(25)00049-8

A well-known controversy in evolutionary genetics is whether dosage compensation is required to address the gene dosage (X:AA) imbalance between the X chromosome and autosomes. ScRNA-seq data can provide in-depth insights into this issue at the single-cell level. However, before conducting the analysis, it is essential to carefully evaluate whether the inherent characteristics of scRNA-seq, such as sparsity, can bias the X:AA expression ratio in mammals.

 Recently, the team led by Professor Chen Xiaoshu from Sun Yat-sen University published an online research paper titled "Human single-cell RNA-sequencing data supports the hypothesis of X chromosome insensitivity but is ineffective in testing the dosage compensation model" in *Molecular Biology and Evolution*. This paper comprehensively studied the inherent characteristics of scRNA-seq to reveal whether it can correctly test the dosage compensation model. 

  The researchers first used simulated scRNA-seq and bulk RNA-seq datasets to evaluate two common X:AA gene selection strategies, namely filtering by gene expression level and filtering by gene expression proportion. They found that both strategies would generate exaggerated X:AA expression ratios, thus artificially supporting the dosage compensation model. 

  In addition, although there were biases in the average expression levels, the researchers discovered that scRNA-seq data could be used to detect differences in expression noise between the X chromosome and autosomes as small as 10%, enabling the study of the distribution of genes that are more insensitive to changes in gene dosage. The analysis of Smart-seq2 data showed that compared with autosomes, the expression noise of the X chromosome increased by 10-15%, and the number of dosage-sensitive genes on the X chromosome significantly decreased. 

  Overall, these results emphasize the need for great caution when interpreting scRNA-seq data, especially when comparing the expression levels of different genes, and provide additional evidence for the hypothesis of X chromosome insensitivity. 

  This article has two authors. Professor Chen Xiaoshu from Sun Yat-sen University is the sole corresponding author of this article, and Dr. Chen Jiabi, a doctoral student enrolled in 2022 and a member of the team, is the sole first author of this article. 

Original link: https://doi.org/10.1093/molbev/msaf004

  In recent years, salt-sensitive hypertension has become a significant public health issue. Salt-sensitive hypertension increases the risk of cardiovascular diseases and is an independent risk factor for cardiovascular diseases and all-cause mortality. Salt-sensitive hypertension is closely related to the impairment of the renal natriuretic mechanism. The dysregulation of the renal epithelial sodium channel (ENaC) protein is one of the important pathophysiological mechanisms for the development of salt-sensitive hypertension. 

  Hypertension is associated with liver function and gut microbiota. Growing evidence shows that bile acids are involved in regulating the physiological and pathophysiological functions of multiple tissues and organs in the body through receptor-dependent and non-receptor-dependent forms, such as metabolic regulation, anti-inflammation, and anti-fibrosis. Recently, the research groups led by Wang Weidong and Li Chunling demonstrated that the activation of the bile acid G-protein-coupled membrane receptor (TGR5) expressed in the principal cells of the renal collecting ducts is involved in regulating the reabsorption of water in the kidneys, thereby affecting blood volume and blood pressure. In January 2025, this research group published an article titled "TGR5 attenuates DOCA-salt hypertension through regulating histone H3K4 methylation of ENaC in the kidney" in the classic journal Metabolism - Clinical and Experimental, further revealing the molecular mechanism by which TGR5 is involved in regulating renal sodium reabsorption and excretion, as well as its potential role in intervening in the development of salt-sensitive hypertension. 

  In DOCA-salt-induced hypertensive mice, endogenous or exogenous TGR5 receptor agonists lithocholic acid or INT-777 significantly reduced blood pressure levels and decreased the expression of renal ENaC protein and genes. TGR5 gene knockout significantly increased blood pressure and renal ENaC expression in DOCA-salt mice. In mpkCCD cells of the renal cortical collecting ducts, the activation of the TGR5 receptor significantly inhibited aldosterone-induced ENaC-mediated sodium influx and decreased the expression of ENaC protein and genes. Through the analysis of chromosomal modifications, it was found that there is a trimethylation modification of lysine at the fourth position of histone H3 (H3K4me3) at the transcriptional start site of the ENaC gene. ChIP-seq analysis and molecular biology experiments showed that there is H3K4me3 enrichment in the renal ENaC gene of DOCA-salt mice, and the activation of TGR5 significantly reversed this enrichment. Further research indicated that the activation of TGR5 significantly reduced the expression and activity of renal histone demethylase 5A (KDM5A), suggesting that TGR5 may be involved in regulating the transcription and translation of ENaC by affecting histone demethylase 5A, thereby regulating renal sodium reabsorption and influencing blood pressure. 

  This study provides important experimental evidence for the regulatory role of the bile acid receptor TGR5 in salt-sensitive hypertension and reveals the molecular mechanism by which TGR5 regulates ENaC expression. This discovery not only deepens the understanding of the pathogenesis of salt-sensitive hypertension but also provides new ideas for the research on renal water and sodium metabolism and blood volume regulation, offering new potential targets for the treatment of hypertension. 

  The co-first authors of this study are Xu Long, a Ph.D. in Physiology from Zhongshan School of Medicine, and Wu Xinyan, a Ph.D. candidate in Pathophysiology. The corresponding authors also include Dr. Wang Lei from Guangzhou University of Chinese Medicine. 

Original link: https://www.metabolismjournal.com/article/S0026-0495(25)00002-2/fulltext

  Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), has become one of the top three fatal cardiovascular diseases worldwide. Although age is a known risk factor and has been incorporated into several VTE risk scoring systems, an individual's social age often fails to reflect their true physical functioning, resulting in inaccurate VTE risk assessments. In recent years, research has shown that the acceleration of "biological age" is a more precise factor affecting the occurrence of various diseases. Therefore, the joint team is the first to propose the inclusion of "biological age" in the risk assessment of VTE to achieve more accurate prevention. At the same time, considering that VTE has a genetic tendency, the estimated heritability is as high as 50%. At present, the frontier view is that genetic risk of disease can be affected by environmental factors, so whether biological aging will change an individual's genetic risk of VTE needs to be studied.

  Recently, A joint team led by Professor Kai Huang of Sun Yat-sen Memorial Hospital, Sun Yat-sen University, and Professor Yi Zhou of Sun Yat-sen Medical College published an online paper entitled Combination of Biological Aging in the American Journal of Hematology (IF=10.1), a Top journal of the first district of the Chinese Academy of Sciences and Genetic Susceptibility Helps Identifying At-Risk Population of Venous Thromboembolism:  A Prospective Cohort Study of 394 041 Participants. Based on blood biomarker data, this study innovatively develops a new thrombus risk recognition model -- VTE PhenoAgeAccel. This model can accurately predict the risk of thrombus by quantifying the biological aging rate of individuals. Compared with traditional methods, the VTE PhenoAgeAccel model can better reflect the dynamic changes in the risk of thrombosis, and can provide individuals with a more personalized and timeliness risk assessment based on the relationship between biological aging and thrombosis. In addition, based on whole genome sequencing data, combined with the latest genetic informatics methods, the study constructed a VTE genetic risk score to quantify an individual's genetic susceptibility. By integrating blood biomarkers, genomic data, and biological aging models, this study demonstrates the innovative application of medical informatics in multi-level, multi-data source risk assessment, providing a new data-driven solution for early identification and personalized prevention of thrombotic disease.

  Studies have shown that accelerated aging will promote the occurrence of VTE, and people with premature aging are more likely to suffer from VTE. People with high genetic risk had significantly higher relative risks of VTE, DVT, and PE than those with low genetic risk. The combination of biological aging and genetic risk can improve the effectiveness of VTE risk assessment, and the combination of the two has a synergistic effect on the increase of VTE risk. Based on this, the team has transformed the model into a clinical diagnostic tool to provide precise strategies for ultra-early identification of people at high risk of thrombosis. Physicians can track an individual's diabetes progression, hematological markers, and genetic risk, providing a scientific basis for personalized treatment and health management.

  Kai Huang, Professor of Sun Yat-sen Memorial Hospital, Sun Yat-sen University, and Yi Zhou, Professor of Sun Yat-sen Medical College are co-corresponding authors of the paper. Hu Zhensheng, a doctoral student of Professor Zhou Yi, is the first author, and Xu Jiatang and Shen Runnan are the co-first authors of the paper.

  Professor Huang Kai's team has long been engaged in artificial intelligence precision diagnosis and treatment, big data and disease risk spectrum identification and clinical database mining, specializing in vascular surgery diseases, such as venous embolism, major artery disease and severe vascular diseases. Professor Zhou Yi's team has long been engaged in the research of health and medical informatization and big data, medical artificial intelligence, medical large model and other related fields. Postdoctoral and graduate students who are interested in this research direction are welcome to join.

The original link: https://doi.org/10.1002/ajh.27605 or https://onlinelibrary.wiley.com/doi/10.1002/ajh.27605

  Graduate students Feng Qiumin and Li Mengzhao, graduate students Lin Zejin and Zhao Danhui from Xiamen University are the co-first authors of the paper, Associate Professor Ye Congting from Xiamen University is the co-corresponding author, and Associate Professor Yao Chengguo from Xiamen University is the final corresponding author. The research was supported by several grants, including the National Natural Science Foundation of China and the Natural Science Foundation of Guangdong Province.

On the afternoon of November 30, the 11th Congress of League Members of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University was officially held in the Alumni Hall on the North Campus. Zhou Jing, Deputy Secretary of the Communist Youth League Committee of Sun Yat-sen University, Chen Baoyu, Deputy Secretary of the Party Committee of Sun Yat-sen School of Medicine, Ding Xiaoyi, Secretary of the Communist Youth League Committee of Sun Yat-sen School of Medicine, Ji Xiaoting, Deputy Secretary of the Communist Youth League Committee, Chen Jintang, Counselor of the 2024 grade, and Guan Qianxuan, Secretary of the Alumni Center, attended this meeting. League member representatives from all grades participated in this meeting.
First of all, the preparatory meeting of the 11th Congress of League Members of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University was held.

The preparatory meeting listened to and voted on the "Report on the Qualification Examination of Representatives of the 11th Congress of League Members of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University (Draft)"; the "Agenda of the 11th Congress of League Members of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University (Draft)"; the "Election Measures for Members of the 11th Committee of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University (Draft)"; and the "List of Chief Scrutineers and Tellers for the Election of the 11th Committee of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University (Draft)". The convening of the preparatory meeting laid a solid foundation for the smooth progress of the formal meeting. The 11th Congress of League Members of Sun Yat-sen School of Medicine, Sun Yat-sen University opened. All participants stood up and sang the "National Anthem of the People's Republic of China" and the "Anthem of the Communist Youth League" together.

Zhou Jing, Deputy Secretary of the Communist Youth League Committee of the university, extended warm congratulations on the successful convening of the 11th Congress of League Members of Sun Yat-sen School of Medicine. She fully affirmed the hard work and outstanding achievements of teachers and students of all grades in the past three years. Meanwhile, on behalf of the Communist Youth League Committee of the university, Deputy Secretary Zhou Jing put forward three expectations for the work of the Communist Youth League of Sun Yat-sen School of Medicine: First, listen to the Party, follow the Party, and effectively enhance the political nature of the Communist Youth League. Second, inspire the vast number of league members and young people to strive for excellence, show the features of the times, and effectively enhance the advanced nature of the Communist Youth League. Third, give full play to the role of a bridge and bond connecting the Party and young people, serve the growth and development of young people, and effectively enhance the mass nature of the Communist Youth League.

At the meeting, all league member representatives listened to, deliberated on and voted on the "Work Report of the 10th Committee of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University (Draft)". The report systematically reviewed the work of the Communist Youth League of the school since the 10th Congress of the Communist Youth League of Sun Yat-sen School of Medicine from four aspects: strengthening political guidance, continuously deepening reforms, expanding volunteer services, and focusing on the second classroom. The report believed that the Communist Youth League Committee of Sun Yat-sen School of Medicine had always put ideological guidance first, carried out theoretical learning in a down-to-earth manner, combined theory with practice, built learning platforms, adhered to deepening the reform of the league organization, strictly implemented the system of "Three Meetings, Two Systems and One Lesson", actively participated in the construction of Chinese-style modernization, adhered to the "simultaneous development of five aspects of education", focused on the second classroom, and continuously standardized and institutionalized the work of the league committee. The report also pointed out that there were still deficiencies in strengthening the integrated construction of the Party, the league and classes, further improving the contribution to the overall situation, and further deepening the organizational reform in our school. The league committee of the school will improve the work in a targeted manner, innovate the working mechanism, consolidate the organizational foundation, lead, unite and serve young students, and contribute youthful strength to promoting the development of youth undertakings and the comprehensive construction of the school.

The candidates for members of the 11th Committee of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University made personal statements. In their statements, the candidates elaborated on their election platforms, reviewed their experiences in league affairs, put forward work ideas, and expressed their enthusiasm for serving youth affairs and playing an exemplary role.

Chen Baoyu, Deputy Secretary of the Party Committee of Sun Yat-sen School of Medicine, gave a special league class titled "Making Good Use of the 'Four Addition and Subtraction' Toolkit to Promote the Inheritance and Innovation of the Work of the Communist Youth League". He described the four additions and subtractions in the work of the league and student affairs of Sun Yat-sen School of Medicine: do "addition" in terms of political height and do "subtraction" in terms of working alone; do "addition" in terms of work depth and do "subtraction" in terms of treating people differently; do "addition" in terms of professional concentration and do "subtraction" in terms of shirking responsibilities; do "addition" in terms of the degree of closed loop and do "subtraction" in terms of weaknesses. Correct the style through learning and promote work through learning. Combine strict management with kind care. Pay attention to both quality and quantity. Have inheritance and also be able to develop. Promote the vast number of league members to jointly build, manage and make decisions on relevant league affairs and jointly create a harmonious and beautiful campus environment. Encourage league members and young people to be strivers in the new era, witnesses of the glorious history, leaders of the beautiful future, and guardians of "Healthy China". Integrate the individual into the collective, run hard on the track of youth, and strive to become builders and successors of socialism.

In accordance with the election measures and procedures of the congress, a total of 15 members of the 11th Committee of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University were elected through the vote of all participants. Deputy Secretary Chen Baoyu announced the list of members, who are (in the order of the number of strokes of their surnames): Ding Xiaoyi, Tian Juntao, Guan Qianxuan, Li Yangfan, Li Xinyan, Wu Jiajia, Zhang Junhao, Zhang Jingxing, Chen Jieyi, Chen Jintang, Tie Hangyu, Luo Xiaoyi, Ji Xiaoting, Kang Jiaqi, Cheng Siyang.

This congress of the Communist Youth League of Sun Yat-sen School of Medicine, Sun Yat-sen University is an important meeting for league members to discuss league affairs together, gather youthful strength, show their responsibilities and promote the vigorous development of the cause of the Communist Youth League. Through this meeting, each league member representative can convey the voices of league members in a serious, responsible, comprehensive and detailed manner, and actively offer suggestions for the construction of the league organization. The league organization can optimize decisions, build a better growth platform for league members, help league members strengthen their sense of responsibility, enhance their enthusiasm for participating in league affairs, promote the close connection between the league organization and league members, deepen mutual trust, create an energetic atmosphere for the construction of the league committee, and demonstrate the spirit and mission of the Communist Youth League of Sun Yat-sen School of Medicine of striving in unity and pursuing excellence.

Keep moving forward and the future will surely be achieved. The league committee of the school will continue to move forward bravely, shoulder the mission of the times, closely follow the pulse of development, gather the strength of young people in the whole school, and continue to strive hard to practice the school motto of Sun Yat-sen University, which is "erudite, inquisitive, reflective, discerning, and steadfast". Remain true to our original aspiration, follow the Communist Party of China, shoulder responsibilities bravely and make new achievements, and let youth shine more brightly in hard work and dedication.

The inheritance of medical knowledge and skills passes down from generation to generation;
The charm of Zhongshan School of Medicine has been renowned for a hundred years.
In the centennial Sun Yat-sen University, the mountains are high and the waters are long;
With a hundred years of glory, we jointly compose a magnificent chapter.

On the morning of November 10th,
The teachers, students, and alumni of Zhongshan School of Medicine gathered together
And grandly held the 2024 Alumni Assembly of Zhongshan School of Medicine of Sun Yat-sen University
And the closing ceremony of the 16th Academic Festival in the Alumni Hall of the North Campus of Sun Yat-sen University.

Professor Zhang Qi, the deputy secretary of the Party Committee of Sun Yat-sen University, Professor Kuang Ming, the assistant president of Sun Yat-sen University and the dean of Zhongshan School of Medicine, Professor Yan Guangmei, the former deputy secretary of the Party Committee and vice president of Sun Yat-sen University, alumnus Zhang Yanhau, the former deputy director of the Health Department of Guangdong Province, Professor Xie Fukang, the former dean of Zhongshan School of Medicine, Researcher Xia Dan, the former Party secretary of Zhongshan School of Medicine, Professor Wang Tinghuai, the vice president of the Alumni Association of Sun Yat-sen University and the president of the Ke Lin Foundation, Professor Chen Minshan, the president of the Zhongshan Medical Alumni Association and the Cancer Prevention and Treatment Center of Sun Yat-sen University, Professor Bei Jinxin, the deputy director of the Office of Education Development and Alumni Affairs of Sun Yat-sen University, Long Bo, the deputy director of the Medical Department of Sun Yat-sen University and the director of the General Affairs Office, Ye Wei, the director of the Hospital Administration Office, Lin Haotian, the director of the Zhongshan Ophthalmic Center, Chen Wangnan, the Party secretary of the Guanghua School of Stomatology and the Affiliated Stomatological Hospital, Yang Jianlin, the Party secretary of the Sun Yat-sen Memorial Hospital, Rong Limin, the dean of the Third Affiliated Hospital, Chen Qikun, the Party secretary of the Seventh Affiliated Hospital, Chen Yanming, the dean of the Eighth Affiliated Hospital, Zhang June, the dean of the School of Nursing, Zhang Yuanquan, the Party secretary of the Commission for Discipline Inspection of the Cancer Prevention and Treatment Center, Li Wenmin, the deputy Party secretary of the Sixth Affiliated Hospital, Huang Yangyang, the chief accountant of the Fifth Affiliated Hospital, the guest representatives of the medical colleges and departments of the university, the leaders at all levels of the university who have worked in Zhongshan School of Medicine, and about 400 alumni, teachers, and students participated in the assembly.
The assembly was presided over by Hao Yajuan, the Party secretary of Zhongshan School of Medicine.

Speech

Professor Zhang Qi, the deputy secretary of the Party Committee of Sun Yat-sen University, delivered a speech at the assembly. On behalf of the university, Professor Zhang Qi extended the warmest welcome to the alumni from all over the world. She said that looking back on the century-old journey, Sun Yat-sen University has become more and more brilliant with the passage of time, and Zhongshan School of Medicine has successfully presented a gift to the centennial Sun Yat-sen University with its continuously rising scientific research strength and strategic ability to serve the country. The alumni of Zhongshan School of Medicine are large in number and have prominent exemplary roles, and they are the backbone of the alumni team of Sun Yat-sen University. She hoped that the alumni from all over the world would integrate their own development into the great tide of national and social development with their alma mater as the bond, and make contributions and show the responsibility of Zhongshan School of Medicine for promoting the great rejuvenation of the Chinese nation in an all-round way with Chinese modernization. Finally, she wished the assembly a complete success and sincerely invited all the alumni to come back to visit often.

School Development Report

Professor Kuang Ming, the assistant president of Sun Yat-sen University and the dean of Zhongshan School of Medicine, made the "Development Report of Zhongshan School of Medicine". Taking his own study experience as the starting point, Dean Kuang Ming introduced the basic situation of Zhongshan School of Medicine in detail to the participants and demonstrated the excellent achievements of the school in discipline construction, talent cultivation, talent introduction and cultivation, etc. Subsequently, Dean Kuang Ming shared the exploration and achievements of the school in the process of high-quality development. He emphasized that in the high-quality development of the school, the leadership of the Party is the direction, the curriculum is the key, the teaching staff is the core, innovation is the orientation, culture is the foundation, and cooperation is the driving force. Finally, Dean Kuang Ming pointed out the bottleneck problems currently restricting the development of the school, such as the teaching staff and teaching reform, and emphasized the need to continuously improve the effectiveness of the curriculum and enhance the international influence.

Alumni Center Inauguration Ceremony

Alumni are an important force in promoting the development of the school. In order to better connect with alumni, unite alumni, and serve alumni, in May this year, the school decided to establish an alumni center. The unveiling ceremony of the alumni center of Zhongshan School of Medicine was held at the assembly. The leaders and guests such as Secretary Zhang Qi, Dean Kuang Ming, Secretary Hao Yajuan, Director Long Bo, Professor Wang Tinghuai, President Chen Minshan, and Deputy Director Bei Jinxin participated in the unveiling.
To ensure the operation of the alumni center, the school hired teachers and alumni who are actively active in the front line of alumni work to hold relevant positions. Secretary Zhang Qi, Professor Yan Guangmei, Professor Xie Fukang, and Secretary Xia Dan came to the stage to issue appointment letters to the appointees. It is believed that the alumni center will surely play an active role, provide more high-quality services for the alumni, and gather more alumni resources to support the development of the school's cause!

Chorus of "China in the Lights"

The students of Zhongshan School of Medicine are not only good at studying and have excellent academic achievements, but also versatile. The choir of Zhongshan School of Medicine has won the special prize in the school-wide choral competition for two consecutive years. Youth is graceful and the mind is broad. The students of the North Campus Choir sang the song "China in the Lights" affectionately, which not only showed their good artistic accomplishment and spiritual outlook, but also sang the youth oath and the praise of the times of "I am strong for the country, please rest assured the Party".

Speech by the President of Zhongshan Medical Alumni Association

With the passage of time, the torch is passed on. The Zhongshan Medical Alumni Association has always been a strong backing for the development of the school. On behalf of the Zhongshan Medical Alumni Association, President Chen Minshan of the Zhongshan Medical Alumni Association delivered a speech, extending warm congratulations on the establishment of the Zhongshan Medical Alumni Center, expressing warm welcome to the alumni representatives from at home and abroad, and wishing the assembly a complete success. He emphasized that the alumni association can closely connect the alma mater with the alumni from all over the world because we all have the common name of "Zhongshan Medical". Finally, he issued an initiative: he hoped that the alumni at home and abroad would be more united and make new contributions to the development of Zhongshan Medical!
In the centennial Zhongshan Medical, the peaches and plums are all over the world. The alumni of Zhongshan Medical, with the earnest expectations of their alma mater, have silently dedicated and actively contributed to the medical and health undertakings in Guangdong, the Greater Bay Area, China, and even the world.

Alumni Representative Speeches

"With a Solid Foundation, Build a Career and Establish a Reputation"
Professor Zhang Jianqing, an alumnus of the class of 1989 of Zhongshan Medical, the president of the Zhongshan Medical Alumni Association in the United States, and an academician of the American Academy of Nursing Sciences, spoke as one of the alumni representatives. Professor Zhang Jianqing's speech revolved around four parts: "memories of youth", "the influence of the alma mater", "growth and insights", and "industry insights and feelings". She said that the influence of the alma mater on her is not only the imparting of knowledge, but also has deeply shaped her values and outlook on life. Looking forward to the future, the medical industry will face rapid changes and great challenges, and the alumni of Sun Yat-sen University in different fields should combine their forces and work together to release a stronger influence of Sun Yat-sen University. She emphasized that in this era full of uncertainties, we need to be people who look for opportunities in crises and build windmills when the wind comes, and make positive contributions to global health.

"For the Welfare of Society, For the Glory of the Country"

Mr. Luo Yilong, an alumnus of the class of 2000 of Zhongshan Medical, a member of the National Committee of the Chinese People's Political Consultative Conference, the vice president of the All-China Youth Federation, and the director of the Macau Health Bureau, spoke as one of the alumni representatives. Mr. Luo Yilong recalled his growth and development experience in Zhongshan Medical. His alma mater is the place that helped him with his medical enlightenment and laid a solid foundation for his development. He said that "graduates of Zhongshan Medical" are a resounding "golden business card" in Macau and a guarantee of comprehensive quality and clinical skills, and the alumni resources of Zhongshan Medical have also become a great help for the career development of the students of Zhongshan Medical. The spirit of "saving people, saving the country, and saving the world, treating diseases, treating the body, and treating the mind" of Zhongshan School of Medicine is in line with and echoes the core value of "loving the country and loving Macau" in Macau. He emphasized that he is willing to continue to be a good contact person between "Macau, China" and "Zhongshan Medical", seize the opportunity of building the Guangdong-Hong Kong-Macao Greater Bay Area, and contribute the wisdom and strength of Zhongshan Medical to the medical and health undertakings of the country and the Greater Bay Area.

"Saving People, Saving the Country, and Saving the World, Treating Diseases, Treating the Body, and Treating the Mind"

Alumnus Liu Bin, a council member of the class of 2007 of the Zhongshan Medical Alumni Association and a chief physician in the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Sun Yat-sen University, spoke as one of the alumni representatives. He said that the medical students of each session, with the goal of "saving people, saving the country, and saving the world, treating diseases, treating the body, and treating the mind", are eager to learn medical knowledge and strive to grow into great doctors for the common people; generations of Zhongshan Medical people have written the medical motto of Zhongshan Medical on the land of the motherland, all over the world, and in the hearts of every patient we have treated with their wisdom, sweat, and even lives, and the future students of Zhongshan Medical will also be like this. The development of medical technology is changing with each passing day, and the doctors in the new era face new challenges and opportunities. Therefore, he entrusted the medical students in the new era to have new responsibilities and new achievements: first, have solid knowledge and excellent basic clinical skills; second, have an international perspective and be good at innovation and creation; third, have a kind heart and a noble ideal.

Donation Scholarship Awarding Ceremony

The "Yixian Fate" Physiology Scholarship was set up by the donation of alumnus Zhu Hui, a graduate student majoring in Physiology in 1987, and alumnus Wu Wenlei, an undergraduate majoring in Stomatology in 1985, to reward the students with excellent grades in the "Physiology" course. The 04 Research Xinglin Senior Scholarship was set up by the donation of the graduate student class of 2004 to reward the undergraduate students with excellent academic achievements. The donation scholarship awarding ceremony was held at the assembly. Alumnus Zhu Hui presented the certificates of the Yixian Fate Physiology Scholarship to Zhang Zhenxia, Xiong Haiting, Du Yuhan, and Tang Shile. Alumni Kong Xiaoping and Xu Jiajian, on behalf of the graduate student alumni of 2004, presented the certificates to the recipients of the 04 Research Xinglin Senior Scholarship, Guo Hongbo, Zheng Mixue, Chen Yanlin, Gao Zirui, Wu Jiajia, and Chen Juexiao.
Xiong Haiting, a student representative of the award-winning students and a student of the eight-year clinical medicine program in 2022, delivered an acceptance speech. Student Haiting said that on the occasion of the approaching centennial anniversary of Sun Yat-sen University, it is an honor to be awarded the Yixian Fate Physiology Scholarship in her academic journey. She extended the highest respect and sincere gratitude to the donors of the Yixian Fate Physiology Scholarship, Zhu Hui and Wu Wenlei. She mentioned that the receipt of the Yixian Fate Physiology Scholarship is not only an recognition of our past efforts, but also an expectation for our future. It is an incentive and a responsibility. In the future, she will actively engage in the research of physiology and continue to move forward on the path of medicine, exploring the unknown and pursuing excellence.

Academic Festival Commendation Ceremony

The Academic Festival of Zhongshan School of Medicine, as a classic academic brand of the school, continues the fearless pursuit of truth, the in-depth exploration of the essence of academics, and the unremitting climb of the scientific research peak of the generations of Zhongshan Medical people. The 16th Academic Festival held this year held 20 wonderful academic report sessions and a series of activities, inviting 188 well-known experts and scholars at home and abroad to communicate and share with the teachers and students of the school on the same stage, including 10 academicians and 35 foreign experts, and a total of more than 3,300 people participated in the activities.
The commendation ceremony of the Youth Academic Salon and Experimental Technology Salon of the 16th Academic Festival of Zhongshan School of Medicine was held at the assembly. Professor Zhou Jiaguo, the vice dean of Zhongshan School of Medicine, and Professor Deng Kai, the vice dean of Zhongshan School of Medicine, presented certificates to the third prize winners. Professor Gao Guoquan, the former vice dean of Zhongshan School of Medicine, and Professor Liu Xianguo, the former vice dean of Zhongshan School of Medicine, presented certificates to the second prize winners. Professor Yan Guangmei of Zhongshan School of Medicine and Professor Zhang Hongqi, a master alumnus of the class of 1990 and a professor at the School of Basic Medical Sciences of Fudan University, presented certificates to the first prize winners.

Recitation

Ke Lin is known as the "master of Zhongshan Medical in one generation". To celebrate the centennial anniversary of the alma mater, the school organized and invited the modern Cantonese opera "Silent Merit" with the red doctor Ke Lin as the protagonist to perform three times on campus, which won wide acclaim. At the end of the assembly, the participants reproduced the climax of the play and recited "My Zhongshan Medical, My Sun Yat-sen University" aloud, expressing the feelings of the people of Zhongshan Medical.

My Zhongshan Medical, My Sun Yat-sen University,
Has written a glorious history and opened a new chapter.
My Zhongshan Medical, My Sun Yat-sen University,
May you grow taller like bamboo joints and be as tall and red as kapok.
My Zhongshan Medical, My Sun Yat-sen University,
May you be as holy and flawless as apricot forest and as lush and leafy as banyan trees.
My Zhongshan Medical, My Sun Yat-sen University,
May you be as majestic and evergreen as Yunshan Mountain and be passed down for a hundred generations like the Pearl River.
Finally, in the melodious chorus of the school song, the 2024 Alumni Assembly and the closing ceremony of the 16th Academic Festival of Zhongshan School of Medicine of Sun Yat-sen University came to a successful conclusion.
The centennial medical school has a profound heritage;
The apricot forest is full of spring and fruitful;
The alumni gather and enjoy the friendship.
Entering a new journey,
Zhongshan School of Medicine will, with a fuller spirit and a higher fighting spirit,
Take root in the land of China, base itself on the Guangdong-Hong Kong-Macao Greater Bay Area,
Continue to move forward in the same direction and at the same pace as the development of the Party and the country.
Wish the alumni happiness and well-being and strive for new heights;
Wish Zhongshan School of Medicine the pursuit of excellence and perseverance;
Wish Sun Yat-sen University new achievements and new glories!

In recent years, with the development of synthetic biology technology, there have been reports of using synthetic brain organoids, spinal cord organoids, and spinal cord-like tissues to repair central nervous system injuries. However, there is a lack of literature on the design and synthesis of organoids/tissues for repairing peripheral nerve defects. Therefore, this study follows the tissue engineering simulation design concept, using synthetic biology technology to load neurotrophin-3 (NT-3) overexpressing genetically engineered Schwann cells (SCs) within a decellularized optic nerve (DON) scaffold with natural uniform longitudinal channels. An artificial peripheral nerve tissue (peripheral nerve tissueoid, PNT) rich in laminin (LAM or LN) and NT-3 and other bioactive factors is manufactured to simulate the structure of peripheral nerve tissue in vitro. It is then transplanted to the site of sciatic nerve defect in an attempt to induce the longitudinal regrowth of axons in neurons expressing LAM or LN receptors and NT-3 receptors, restoring the function of the sciatic nerve and exploring the mechanism by which PNT grafts induce sciatic nerve regeneration.

To verify the above hypothesis, the joint team of Professor Zeng Yuanshan, Professor Xu Yangbin and Deputy Chief Physician Zhu Zhaowei from the First Affiliated Hospital of Sun Yat-sen University, Deputy Chief Physician He Bo from the Third Affiliated Hospital, and Deputy Researcher Li Ge from Guangdong Provincial People's Hospital transplanted PNT at the site of sciatic nerve defect. The results showed that PNT transplantation based on synthetic biology technology can repair the structure of the sciatic nerve defect and restore the sensory and motor functions of the paralyzed limb. This may involve inducing the interaction between NT-3 and its receptor TrkC cells, as well as the interaction between laminin and its receptor integrin αVβ6 axons, which play a role in chemotaxis, adhesion, and intrinsic drive mechanisms in promoting the targeted regeneration of neuronal axons within the PNT.

The results of testing the PNT showed that the unique bioactive matrix components LAMC3 or LN on the longitudinal channel walls of DON can form an NT-3-enriched area by binding with NT-3 secreted by genetically engineered Schwann cells (NT-3-SCs). The NT-3-SCs located in the PNT can also bind to the self-secreted NT-3 through their cell surface NT-3 receptor TrkC: on the one hand, it promotes the better colonization of NT-3-SCs in the NT-3-deposited area, forming a dynamic bioactive niche of PNT; on the other hand, the interaction between NT-3 and TrkC (ligand and receptor) further activates NT-3-SCs to better survive and secrete various neurotrophic factors, forming a microenvironment and structural basis for inducing the regrowth of neuronal axon bundles.

Transplanting the above PNT into the sciatic nerve defect site of rats, the animals survived for 8 weeks postoperatively. Through behavioral testing of the animals and detection of nerve-related tissues and functions, the results showed that the sciatic nerve index, limb rotation angle, and mechanical pain sensitivity test values of the PNT transplantation group were close to those of the autologous peripheral nerve transplantation group, with significant improvement compared to other transplantation control groups. Nerve-related tissue detection showed that compared with other transplantation control groups, the PNT transplantation group could promote the faster passage of regenerating axons across the sciatic nerve defect/transplant site to the target tissue and re-form myelin sheaths, thereby improving the sensory and motor functions of target skin and muscle tissues that had lost nerve innervation. Anterograde and retrograde tracing of nerve tissues indicated that regardless of whether in the PNT graft or at the distal end of the sciatic nerve defect/transplant site, adeno-associated virus (AAV) labeled dorsal root ganglion (DRG) neurons and their regenerated calcitonin gene-related peptide-positive axons could specifically express TrkC.

Transcriptome analysis of DRGs innervating the sciatic nerve defect/transplant side of the hind limb in the PNT transplantation group and the simple DON transplantation group revealed the potential molecular mechanisms of neuronal axon regeneration. The results revealed that the PNT graft provides a biophysical bridge at the sciatic nerve defect/transplant site to induce DRG neuronal axon regeneration. The NT-3 enriched on the longitudinal channel walls of the PNT by the genetically engineered Schwann cells activates DRG neurons and their axons to express the receptors TrkC and integrin αVβ6 (Integrin αVβ6) that combine with them, thereby activating the PI3K/AKT signaling pathway related to the intrinsic drive of neurons and enhancing the efficacy of long-distance axon regeneration.

Schematic diagram shows: (1) LN or LAMININ on the PNT channel wall can bind with NT-3 to form an NT-3-enriched area, which is conducive to the colonization and growth of genetically engineered Schwann cells (NT-3-S) expressing TrkC and forming a niche for regenerating axons to form myelin sheaths on the PNT. (2) The continuous secretion of NT-3 by the PNT can promote the extension of TrkC-expressing neuronal axons to the sciatic nerve defect/transplant site, which may involve the interaction between NT-3 and TrkC as well as LAMININ and integrin αVβ6.

Original Article Link: https://pubmed.ncbi.nlm.nih.gov/39531746/