Personal profile
Work experience

2022.10-present Assistant Professor, Zhongshan School of Medicine, Sun Yat-sen University

Educational experience

2019.08-2022.06 Doctor of Forensic Medicine, China Medical University

2016.09-2019.07 China Medical University Master of Forensic Medicine

2011.09-2016.07 China Medical University Bachelor of Forensic Medicine

Research direction
The damage of narcotic drugs to central nervous system and its mechanism of action

Academic achievement
Representative results (* On behalf of co-first author)

1. Yao H*, Zhang D*, Yu H, Yuan H, Shen H, Lan X, Liu H, Chen X, Meng F, Wu X, Zhang G,  Wang X. Gut microbiota regulates chronic ethanol exposure-induced depressive-like behavior through hippocampal  NLRP3-mediated neuroinflammation. Molecular Psychiatry.2022. Doi: 10.1038/s41380-022-01841-y.

2. Yao H*, Zhang D*, Yu H, Shen H, Lan X, Liu H, Chen X, Wu X, Zhang G,  Wang X. Chronic ethanol exposure induced anxiety-like behaviour by altering gut microbiota and GABA system. Addiction  Biology. 2022 Sep; 27(5):e13203. Doi: 10.1111/adb.13203.

3. Yao H*, Zhang D*, Yu H, Shen H, Lan X, Liu H, Chen X, Wu X, Zhang G,  Wang X. AMPAkine CX516 alleviated chronic ethanol exposure-induced neurodegeneration and depressive-like behavior in  mice. Toxicology and Applied Pharmacology. 2022 Mar 15; 439:115924. Doi: 10.1016 / j.t. aap. 2022.115924.

4. Yao H*, Shen H*, Yu H*, Wang C, Ding R, Lan X, Tash D, Wu X, Wang X,  Zhang G. Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1.  Physiology & Behavior. 2021 May 15; 234:113387. Doi: 10.1016 / j. hysbeh. 2021.113387.

5. Yao H*, Guo W*, Suo L, Li G, Wang Y, Chen Y, Sun Y,  Ding R. Preventive effects of the AMPA receptor potentiator LY450108 in an LPS-induced depressive mouse model.  Behavioural Brain Research. 2022 Apr 29; 424:113813. Doi: 10.1016 / j.b br. 2022.113813.

6. Yu X*, Yao H*, Zhang X, Liu L, Liu S, Dong Y. Comparison of LPS and MS-induced depressive mouse model:  behavior, inflammation and biochemical changes. BMC Psychiatry. 2022 Sep 5; 22(1):590. Doi: 10.1186/s12888-022-04233-2.

7. Wen G*, Yao H*, Li Y, Ding R, Ren X, Tan Y, Ren W, Yu H, Zhan X, Wang X, Xu E, Yao J, Zhang G, Lu Y,  Wu X. Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress  Model. Frontiers in Psychiatry. 2019 Apr 30; Also 7. Doi: 10.3389 / fpsyt. 2019.00287.

Participate in other research work

1.  Xia Z, Wang C, Wang X, Yu H, Yao H, Shen H, Lan X, Wu X,  Zhang G. NCX3 alleviates ethanol-induced apoptosis of SK-N-SH cells via the elimination of intracellular calcium ions.  Toxicology In Vitro. 2021 Apr; 72:105104. Doi: 10.1016 / j.t. iv. 2021.105104.

2. Wang X, Yu H, Wang C, Liu Y, You J, Wang P, Xu G, Shen H, Yao H, Lan X, Zhao R, Wu X,  Zhang G. Chronic ethanol exposure induces neuroinflammation in H4 cells through TLR3 / NF-κB pathway and anxiety-like behavior in male C57BL/6 mice. Toxicology. 2020 Dec 15; 446:152625. Doi: 10.1016 / j.t. ox. 2020.152625.

3. Ding R, Tan Y, Du A, Wen G, Ren X, Yao H, Ren W, Liu H, Wang X, Yu H, Yao J, Li B, Zhang G, Lu Y,  Wu X. Redistribution of Monocarboxylate 1 and 4 in Hippocampus and Spatial Memory Impairment Induced by Long-term  Ketamine Administration. Frontiers in Behavioral Neuroscience. 2020 Apr 17; 14:6 0. Doi: 10.3389 / fnbeh. 2020.00060.

4. Li Y, Ding R, Ren X, Wen G, Dong Z, Yao H, Tan Y, Yu H, Wang X, Zhan X, Yao J, Lu Y, Zhang G,  Wu X. Long-term ketamine administration causes Tau protein phosphorylation and Tau protein-dependent AMPA receptor  reduction in the hippocampus of mice. Toxicology Letters. 2019 Oct 15; 315:107-115. Doi: 10.1016 / j.t. oxlet. 2019.08.023.

5. Li Y, Shen R, Wen G, Ding R, Du A, Zhou J, Dong Z, Ren X, Yao H, Zhao R, Zhang G, Lu Y,  Wu X. Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration. Frontiers in Pharmacology. 2017 Mar 20; "9. Doi: 10.3389 / fphar. 2017.00139.