Personal profile

Zhang Translation is an associate professor and master tutor of Sun Yat-sen School of Medicine, Sun Yat-sen University. He received his PhD from Sun Yat-sen University in 2016. From 2016 to 2021, he worked as a postdoctoral fellow and special associate research fellow at Sun Yat-sen University.
The research direction is the regulation of T lymphocyte anti-virus and anti-tumor immune response. The main academic achievements are the identification of the molecular biological mechanism of T cell immune surveillance of novel coronavirus escape; Cellular immune response mechanism of novel COVID-19 nanoparticle vaccine; Amino acid signaling regulates the immune response mechanism of T cells. With the first or corresponding author (including co-authors) in PNAS，Immunity，Cancer Res，J Immunother Cancer，Cell Reports，Signal Transduct Target Ther，J Immunol，J Virology And other international journals have published more than 10 high-impact research results. Presided over the National Natural Science Foundation of the major research and development program (cultivation project) and youth project, Guangdong Province Outstanding Youth Science Fund and other scientific research projects.

Academic achievement

Representative academic works

1. Chen Y#, Yan S#, Pu Z, Feng J, Tan L, Li Y, Hu H, Huang H, Lin Y, Peng Z, He X, Huang F*, Zhang H*, Zhang Y*. Dopamine/DRD5 Signaling Axis Modulates CD8+ T cells into the CD103+ Tissue-resident Memory Fate and Their Antitumor Immunity. Cancer Research.
2. Zhang Y#, Li R#, Li Y#, Yang H, Zhou L, Yuan J, Pan T, Liu B, Zhang H*, He Y*. Antibody Response and Cross-Neutralization After Omicron BA.2 Infection. Signal Transduction and Targeted Therapy. 
3. Zhang Y , Chen Y, Li Y, Huang F, Luo B, Yuan Y, Xia B, Ma X, Yang T, Yu F, Liu J, Liu B, Song Z, Chen J, Yan S, Wu L, Pan T, Zhang X, Li R, Huang W, He X, Xiao F, Zhang J*, Zhang H*. The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Downregulating MHC-Ι. Proceedings of the National Academy of Sciences, 2021, 118(23)
4. Zhang Y , Yan S, Hu H, Li Y, Tan L, Chen Y, Peng Z, Yuan Y, Liu W, Huang W, Yu F, He X, Li B*, Zhang H*. Amino Acids and RagD Potentiate mTORC1 Activation in CD8+ T Cells to Confer Antitumor Immunity. Journal for ImmunoTherapy of Cancer, 2021, 9(4).
5. Yuan Y#, Zhang X#, Chen R#, Li Y, Wu B, Li R, Zou F, Ma X, Wang X, Chen Q, Deng J, Zhang Y, Chen T, Lin Y, Yan S, Zhang X, Li C, Bu X, Peng Y, Ke C, Deng K, Pan T, He X, Zhang Y*, and Zhang H*. A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-2. Cell Reports. 2021: 110256
6. Ma X#, Zou F#, Yu F#, Li R#, Yuan Y#, Zhang Y#, Zhang X, Deng J, Chen T, Song Z, Qiao D, Zhan Y, Liu J, Zhang J, Zhang X, Peng Z, Li Y, Lin Y, Liang L, Wang G, Chen Y, Chen Q, Pan T, He X, Zhang H. Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses. Immunity. 2020, 53(6): 1315-1330. e9
7. Pan T#, Hu Z#, Hu F#, Zhang Y#, Liu B, Ke C, She Q, He X, Tang X*, Zhang H*. Significantly reduced abilities to cross-neutralize SARS-CoV-2 variants by sera from convalescent COVID-19 patients infected by Delta or early strains. Cellular & Molecular Immunology. 2021: 1-3.
8. Zhang Y #, Chen Y#, Ma R, Jiang Y, Liu J, Lin Y, Chen S, Xia M, Zou F, Zhang J, Pan T, Wang L, Wei L*, Zhang H*. UHRF1 Controls Thymocyte Fate Decisions Through the Epigenetic Regulation of EGR1 Expression. The Journal of Immunology. 2020, 204(12): 3248-3261.
9. Luo B#, Zhan Y#, Liu J, Luo M, Dong H, Liu J, Lin Y, Zhang J, Wang G, Verhoeyen E, Zhang Y*, Zhang H*. Engineered Production of Anti-PD1 Antibody-Expressing Long-lived Plasma Cells by CRISPR/CAS9-Mediated Targeted Gene Integration. Cell Death and Diseases. 2020 Nov 12;11(11):973.
10. Zhang Y， Liu W, Chen Y, Liu J, Wu K, Su L, Zhang W, Jiang Y, Zhang X, Zhang Y, Liu C, Tao L, Liu B*, and Zhang H*. A cellular microRNA facilitates regulatory T lymphocyte development by targeting the FOXP3 promoter TATA-box motif. The Journal of Immunology. 2018. 200(3):1053-1063.
11. Pan T, Peng Z, Tan L, Zou F, Zhou N, Liu B, Liang L, Chen C, Liu J, Wu L, Liu G, Peng Z, Liu W, Ma X, Zhang J, Zhu X, Liu T, Li M, Huang X, Tao L, Zhang Y*, and Zhang H*. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Potently Inhibit the Replication of Zika Viruses by Inducing the Degradation of Axl. Journal of Virology. 2018, 92(20): e01018-18.
12. Chen Y#, Yu F #, Jiang Y, Chen J, Wu K, Chen X, Lin Y, Zhang H, Li L*, and Zhang Y*. Adoptive Transfer of Interleukin-21-stimulated Human CD8+ T Memory Stem Cells Efficiently Inhibits Tumor Growth. Journal of Immunotherapy. 2018, 41(6): 274. (IF:4.5).