Personal Profile
Xin Wenjun, male, professor and doctoral supervisor. He is the director of the Physiology Teaching and Research Section at the Zhongshan School of Medicine, Sun Yat-sen University. He is a distinguished Zhuhai Scholar Professor and an outstanding young talent of the new century recognized by the Ministry of Education. He serves as the chairman of the Guangdong Neurological Society and the chairman of the Guangdong Physiology Society.

His main research areas focus on the neural mechanisms and interventions of sensory/emotional disorders and substance dependence. He has elucidated the key factors inducing acute pain caused by chemotherapeutic drugs, providing a novel concept for understanding the occurrence of acute pain. Meanwhile, he has discovered that inflammatory responses may be an important cause of the chronicization of acute pain and the diverse manifestations of sensory/emotional disorders.

He has successively presided over more than 20 national and provincial-level scientific research funds. He has published over 80 SCI papers. As the last corresponding author, he has published more than 30 papers in a series of traditional academic journals such as Science Advances, Nature Communication, Science Signaling (cover article), The Journal of Neuroscience, Anesthesiology, and Pain. He serves as the chief editor of the fourth edition of the national-level planned textbook Physiology (published by Science Press, with nearly 10,000 copies used annually, covering more than 20 undergraduate institutions) and the deputy chief editor of Comprehensive Ability Examination for Western Medicine Clinical Medicine - Essentials of Physiology.

Academic Achievements
Partial papers published as the corresponding author

1. Huan-Min Liu, Ming-Lu Liao, Guan-Xi Liu, Lai-Jian Wang, Dian Lian, Jie Ren, Xin-Tian Chi, Zhuo-Ran Lv, Meng Liu, Yan Wu, Ting Xu, Jia-You Wei, Xia Feng, Bin Jiang, Xue-Qin Zhang, Wen-Jun Xin (2023) IPAC integrates rewarding and environmental memory during the acquisition of morphine CPP. Science Advances, Jun 23;9(25):eadg5849. doi: 10.1126/sciadv.adg5849.
2. Ting Xu, Zhen-Yu Li, Meng Liu, Su-Bo Zhang, Huan-Huan Ding, Jia-Yan Wu, Su-Yan Lin, Jun Liu, Jia-You Wei, Xue-Qin Zhang, Wen-Jun Xin (2023) CircFhit Modulates the GABAergic Synaptic Transmission via Regulating the Parental Gene Fhit Expression in the Spinal Dorsal Horn in A Rat Model of Neuropathic Pain. Neuroscience Bulletin, doi:10.1007/s12264-022-01014-5 (2023).
3. Zhao YT, Deng J, Liu HM, Wei JY, Fan HT, Liu M, Xu T, Chen TF, He JY, Sun WM, Jia TY, Zhang XQ, Xin WJ (2022) Adaptation of prelimbic cortex mediated by IL-6/STAT3/Acp5 pathway contributes to the comorbidity of neuropathic pain and depression in rats. J Neuroinflammation 19:144
4. Xu T, Liu CC, Xin WJ*: The epigenetic mechanisms involved in chronic pain in rodents: A mini-review. Curr Neuropharmacol 2021
5. Zhang SB#, Lin SY#, Liu M#, Liu CC#, Ding HH, Sun Y, Ma C*, Guo RX, Lv YY, Wu SL, Xu T*, Xin WJ*: CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain. Nature Communication 2019; 10: 4119
6. Liu GX#, Wei JY#, Liu M, Shi WJ, Song LH, Li S, Zhu SQ, Xin WJ*, Zhang XQ*: Epigenetic upregulation of hippocampal CXCL12 contributes to context spatial memory-associated morphine conditioning. Brain Behavior And Immunity 2019
7. Zhang XL#, Ding HH#, Xu T#, Liu M#, Ma C, Wu SL, Wei JY, Liu CC, Zhang SB, Xin WJ*: Palmitoylation of delta-catenin promotes kinesin-mediated membrane trafficking of Nav1.6 in sensory neurons to promote neuropathic pain. Science Signal 2018; 11
8. Liu H#, Wei JY#, Liu M#, Wu SL, Ma C, Liu CC, Huang KM, Zhang XQ, Guo RX, Zhang K, Xin WJ*: Epigenetic upregulation of CXCL12 expression contributes to the acquisition and maintenance of morphine-induced conditioned place preference. Experimental Neurology 2018; 306: 55-63
9. Jiang JX#, Liu H#, Huang ZZ, Cui Y, Zhang XQ*, Zhang XL, Cui Y, Xin WJ*: The role of CA3-LS-VTA loop in the formation of conditioned place preference induced by context-associated reward memory for morphine. Addiction Biology 2018; 23: 41-54
10. Xu T#, Zhang XL#, Ou-Yang HD, Li ZY, Liu CC, Huang ZZ, Xu J, Wei JY, Nie BL, Ma C, Wu SL, Xin WJ*: Epigenetic upregulation of CXCL12 expression mediates antitubulin chemotherapeutics-induced neuropathic pain. Pain 2017; 158: 637-648

Research Projects

National Natural Science Foundation of China General Projects

• "The Role and Mechanism of circIft20/Egr4 in the Induction and Maintenance of Chemotherapy-Induced Hyperalgesia Mediated by", January 1, 2020 - December 31, 2023, 590,000 yuan, Principal Investigator.
• "The Role and Mechanism of Upregulated δ-catenin in Mediating Pathological Pain through Palmitoylation", No. 31671090, January 1, 2016 - December 31, 2019, 670,000 yuan, Principal Investigator.
• "The Role of miRNA in the Inhibition of Pathological Pain by the sst2A Receptor in Spinal Cord GABAergic Neurons", No. 32016A030308003, January 1, 2016 - December 31, 2019, 1,000,000 yuan, Principal Investigator.
• "The Role and Mechanism of TLR4-Mediated Microglia in the Ventral Tegmental Area (VTA) Participating in Morphine Addiction", No. 81271474, January 1, 2013 - December 31, 2016, 700,000 yuan, Principal Investigator.
• "The Role of the TLR4/CCL2 Signaling Pathway in Spinal Microglia in Paclitaxel-Induced Central Sensitization and Hyperalgesia", No. 31171034, January 1, 2012 - December 31, 2015, 700,000 yuan, Principal Investigator.

Guangzhou Key Area R & D Program

• "Major Science and Technology Special Project of 'Brain Science and Brain-Inspired Basic Research' in Guangzhou Key Areas: Brain Mechanisms of Emotional/Sleep Disorders Induced by Chronic Stress and the Clinical Translation of Non-Drug Interventions", April 1, 2022 - March 31, 2025, 5,000,000 yuan, Principal Investigator.

Guangdong Provincial Science and Technology Plan Projects

• "Research on the Diagnosis and Treatment Methods of Depression", 400,000 yuan, Sub-project.

Zhuhai High-Level Health Team Projects

• "Clinical Translation Research on the Neuroimmune Mechanisms and Treatment of Co-morbidities of Chronic Pain, Depression and Cognitive Disorders", August 2018 - July 2023, 1,000,000 yuan.

National Natural Science Foundation of China General Projects (Continued)

• "The Role and Mechanism of circIft20/Egr4 Mediating Chemotherapy Drug-Induced Hyperalgesia Production and Maintenance", January 1, 2020 - December 31, 2023, 590,000 yuan, Principal Investigator.