Personal Profile

Zhao Meng, Doctor of Philosophy, is a professor and doctoral supervisor at the Zhongshan School of Medicine, Sun Yat-sen University. He was awarded the National Science Fund for DistinguiHed Young Scholars (2023), the National Excellent Youth Science Fund (2018), and was selected as a young talent under the "Overseas High-Level Talents" Program by the Organization Department of the CPC Central Committee (2016). He is also the recipient of the 2024 China Stem Cell Research Innovation Scientist Award.

He serves as a member of the Committee on Hematopoietic Physiology of the Chinese Physiological Society, the vice-chairman of the Youth Committee of the Committee on Experimental Hematology of the Chinese Pathophysiological Society, a member of the Committee on Basic and Translational Medicine of the Chinese Geriatrics Society, and a member of the Youth Committee of the Chinese Pathophysiological Society.

Zhao Meng graduated from Shandong University in 2002 with a Bachelor of Medicine degree. In 2009, He obtained her Ph.D. in Biochemistry and Molecular Biology from the Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, under the supervision of Academician Chen Guoqiang of Shanghai Jiao Tong University School of Medicine. Since 2010, He has been conducting postdoctoral research at the Stowers Institute for Medical Research in the United States, working with the renowned Chinese stem cell expert Professor Linheng Li (Li Lingheng). In 2016, He was introduced back to China as an urgently needed talent under the "Hundred Talents Program" of Sun Yat-sen University and has been working there ever since.

He is mainly engaged in research on the regulatory mechanisms of hematopoietic stem cell aging and leukemia stem cell drug resistance, as well as tumor immunotherapy. In recent years, as a corresponding author, He has publiHed multiple papers in academic journals such as Nat Cell Biol (2 papers), Cell Stem Cell, Blood (3 papers), JEM, eLife, Adv Sci, and JHO, with a total citation count of over 3,000 times. Her research achievements were consecutively selected as one of the Top Ten Research Progresses in Hematology in China in 2022 and 2023, and He received the 2024 China Stem Cell Research Innovation Scientist Award. He has applied for 8 domestic patents (4 approved) and 5 international patents (2 approved) related to hematopoietic microenvironment repair and mesenchymal stem cells. He has also written 2 monographs on hematopoietic stem cells and publiHed review articles in journals such as Blood and Cell Research.

He serves as a reviewer for journals such as Cell Stem Cell, Nat Cell Biol, and Blood. He is also an expert reviewer for the National Natural Science Foundation of China's Excellent Youth Fund, DistinguiHed Young Scholars Fund, second-round review expert, Yangtze River Scholars Program reviewer, National Ten Thousand Talents Plan Leading Talent meeting review expert, and Jiangsu Province Climbing Plan meeting review expert.

Academic Achievements

2024

1. Qi Lou#, Kaizheng Jiang#,Xiaoqi Wang#, Yuan Pan#,Guo Qiu#, Binghuo Wu, Lisha Yuan, Siyu Xie, Jian Chen, Quanhui Xu, Meng Zhao*, Linjia Jiang*. (2024). IGF1R signaling in perinatal mesenchymal stem cells determines definitive hematopoiesis in bone marrow. Blood  2024024258. （*通讯作者，影响因子21）
2. Xi Xu#, Yanhui Yu#, Wenwen Zhang#, Weiwei Ma#, Chong He#,Guo Qiu, Xinyi Wan, Qiong Liu, Minyi Zhao, Jiayi Xie, Fang Tao,John M. Perry, Qifa Liu, Shuan Rao*, Xunlei Kang*,Meng Zhao* & Linjia Jiang*(2024). SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming. Nature Cell Biology 26,464–477.（*通讯作者，影响因子17.3） (同期评述推荐文章https://www.nature.com/articles/s41556-024-01350-w)/zh-hans/article/10589

2023

1. Yanhui Yu#, Yabin Meng#, Xi Xu#, Tong Tong#, Chong He, Liying Wang, Kaitao Wang, Minyi Zhao,Xinru You, Wenwen Zhang, Linjia Jiang*, Jun Wu* and Meng Zhao* (2023). A Ferroptosis-Inducing and Leukemic Cell-Targeting Drug Nanocarrier Formed by Redox-Responsive Cysteine Polymer for Acute Myeloid Leukemia Therapy. ACS Nano 17(4): 3334-3345（*通讯作者，影响因子18.027）
2. Xi Xu#, Wenwen Zhang#, Li Xuan#, Yanhui Yu, Wen Zheng, Fang Tao,Jacqelyn Nemechek, Chong He, Weiwei Ma, Xue Han, Siyu Xie,Minyi Zhao, Jian Wang, Yuhua Qu, Qifa Liu, John M. Perry, Linjia Jiang* & Meng Zhao*. (2023) PD-1 signalling defines and protectsleukaemic stem cells from T cell receptor-induced cell death in T cell acutelymphoblastic leukaemia. Nature Cell Biology 25, 170–182. （*通讯作者，影响因子17.3）

2022

1. Changzheng Li#, Binghuo Wu#, Yishan Li#, Yaxi Liu#, Jin Wang#, Jiayi Xie, Xi Xu, Xiaobin Tian, Zhitao Ye, Jingjing Guan, Jie Chen, Siyu Xie, Baolin Zhang,Boyong Cai, Qianhao Wang, Haopeng Yu, Tian Lan, Cheuk Him Man, Xunlei Kang, Pengxu Qian, John M. Perry, Aibin He, Linjia Jiang, Meng Zhao*.（2022）Loss of sphingosine kinase promotes the expansion of hematopoietic stem cells by improving their metabolic fitness.Blood. 140(15):1686-1701.（*通讯作者，影响因子20.3）/zh-hans/article/9813
2. Changzheng Li#, Binghuo Wu#, Yishan Li#, Jie Chen, Zhitao Ye, Xiaobin Tian, Jin Wang, Xi Xu, Shuai Pan, Yucan Zheng, Xiongwei Cai, Linjia Jiang, and Meng Zhao*.(2022) Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2a axis. Cell Stem Cell 29, 1119–1134.（*通讯作者，影响因子25.269）/zh-hans/article/9624
3. Xi Xu#, Jian Wang#, Tong Tong#, Wenwen Zhang, Jin Wang, Weiwei Ma, ShunqingWang, Dunhua Zhou, Jun Wu*, Linjia Jiang*, Meng Zhao*.（2022）A self-assembled leucine polymer sensitizes leukemic stem cells to chemotherapy by inhibiting autophagy in acute myeloid leukemia. Haematologica 107(10):2344-2355（*通讯作者，影响因子11.047）/zh-hans/article/9444
4. Qi Lou#, Kaizheng Jiang#, Quanhui Xu#, Lisha Yuan, Siyu Xie, Yuan Pan, Jian Chen, Jun Wu, Jiang Zhu, Linjia Jiang*, Meng Zhao*.（2022）The RIG-I-NRF2 axis regulates the mesenchymal stromal niche for bone marrow transplantation.Blood 139(21):3204-3221.（*通讯作者，影响因子20.3）/zh-hans/article/9424
5. Changzheng Li#, Xinru You#, Xi Xu#, Binghuo Wu, Yuye Liu, Tong Tong, Jie Chen,Yishan Li, Chunlei Dai, Zhitao Ye, Xiaobin Tian, Yan Wei, Zechen Hao, Linjia Jiang*,Jun Wu*, Meng Zhao*.（2022） A metabolic reprogramming amino acid polymer as an immunosurveillance activator and leukemia targeting drug carrier for T-cell acute lymphoblastic leukemia.ADVANCED SCIENCE. 9(9):e2104134（*通讯作者，影响因子17.521）/zh-hans/article/9394
6. Jin Wang#, Jiayi Xie#, Daosong Wang#, Xue Han#, Minqi Chen, Guojun Shi*,Linjia Jiang*, Meng Zhao*.（2022）CXCR4high megakaryocytes regulate host-defense immunity against bacterial pathogens. ELIFE. 2022;11:e78662（*通讯作者，影响因子8.713）

2021

1. Yunxin Zeng#, Xinyu Zhang#, Dongjun Lin#, Xiaohui Feng, Yuye Liu, Zhengwen Fang, Weijian Zhang,Yu Chen, Meng Zhao*, Jun Wu* and Linjia Jiang*.(2021) A lysosome-targeted dextran-doxorubicin nanodrug overcomes doxorubicin-induced chemoresistance of myeloid leukemia. Journal of hematology & oncology. (2021) 14:189（*通讯作者，影响因子17.388）/zh-hans/article/9378
2. Jiayi Xie＃, Qi Lou＃, Yunxin Zeng＃, Yingying Liang, Siyu Xie, Quanhui Xu, Lisha Yuan, Jin Wang, Linjia Jiang, Lisha Mou*, Dongjun Lin* and Meng Zhao*.Single-Cell Atlas Reveals Fatty Acid Metabolites Regulate the Functional Heterogeneity of Mesenchymal Stem Cells. Frontiers in Cell and Developmental Biology. 2021 9:653308.（*通讯作者，影响因子6.7）
3. Qi Lou#, Minyi Zhao#, Quanhui Xu#, Siyu Xie#, Yingying Liang, Jian Chen,Lisha Yuan, Lingling Wang, Linjia Jiang, Lisha Mou*, Dongjun Lin* and Meng Zhao*. Retinoic Acid Inhibits Tumor-Associated Mesenchymal Stromal Cell Transformation in Melanoma. Frontiers in Cell and Developmental Biology. 2021 9:658757.（*通讯作者，影响因子6.7）

Early achievements

1. Ye, ZA#, Su, ZW#, Xie, SY,Liu, YY , Wang, YQ,Xu, X,Zheng, YQ*,Zhao, M*,Jiang, LJ*. Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration. ELIFE（2050-084X）.2020;9:e55771.（*通讯作者，影响因子8.14）
2. Zhao, M., Tao, F., Venkatraman, A., Li, Z., Smith, S. E., Unruh, J., Chen, S., Ward, C., Qian, P., Perry, J. M., Marshall, H., Wang, J., He, X. C., and Li, L. (2019) N-cadherin expressing bone and marrow stromal progenitor cells maintain reserve hematopoietic stem cells. Cell Rep 26, 652-669 e656.（影响因子9.42）
3. Jiang, L., Han, X., Wang, J., Wang, C., Sun, X., Xie, J., Wu, G., Phan, H., Liu, Z., Zhang, C.*, Zhao, M.*, and Kang, X*. (2018) SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-beta signaling. The Journal of experimental medicine （*通讯作者，影响因子12）
4. Zhao, M., Li, L.2016 Dissecting the bone marrow hematopoietic stem cell niches. Cell Res. 26: 975-976（影响因子14.82）
5. Zhao, M., Li, L. 2015. Osteoblast ablation burns out functional stem cells. Blood. 2015;125(17):2590-2591. （影响因子11.84）
6. Zhao, M., Perry, J.M., Marshall, H., Venkatraman, A., Qian, P., He, X.C., Ahamed, J., and Li, L. 2014. Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nat Med 20, 1321-1326. (Cover article). Featured in: Day, R. B. & Link, D. C. 2014 Megakaryocytes in the hematopoietic stem cell niche. Nat Med 20, 1233-1234. （影响因子30.36）
7. Zhao, M., Ross, J.T., Itkin, T., Perry, J.M., Venkatraman, A., Haug, J.S., Hembree, M.J., Deng, C.X., Lapidot, T., He, X.C., et al. 2012. FGF signaling facilitates postinjury recovery of mouse hematopoietic system. Blood 120:1831-1842. （影响因子11.84）
8. Venkatraman, A., He, X.C., Thorvaldsen, J.L., Sugimura, R., Perry, J.M., Tao, F., Zhao, M., Christenson, M.K., Sanchez, R., Yu, J.Y., et al. （2013）. Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence. Nature500:345-349. （影响因子38.12）

Treatise

1. Zhao,M, Qian,P. 2024  Hematopoietic Stem Cells,Keystone of Tissue Development and Regenerative Medicine. Springer，ISBN: 9789819974702
2. Venkatraman, A., Zhao, M., and Li, L. 2014. “The hematopoietic stem cell niche”, Biomaterials and Regenerative Medicine, Cambridge University Press, ISBN: 9781107012097
3. He X. C., Li Z., Sugimura. R., Ross J., Zhao, M., and Li L. 2014. “Homing and Migration Assays of Hematopoietic Stem/Progenitor Cells”, Hematopoietic Stem Cell Protocols, Springer
4. Zhou.B.O, Li L, Zhao, M*. 2017 “The evolvement of hematopoietic stem cell niches”,   Advance in Stem Cells and their niche. (*通讯作者)  ELSEVIER

Research Projects

• 2024 - 2028: National Natural Science Foundation of China Distinguished Young Scientists Fund, Regulation Mechanisms of Normal and Leukemia Stem Cells, Project No. 82325002, Ongoing, Principal Investigator, Funding: 4 million yuan.
• 2024 - 2026: Guangzhou Science and Technology Plan Project, Decoding the Regulation Mechanisms of Leukemia Stem Cells in Multiple Dimensions, Project No. 2024A04J6472, Ongoing, Principal Investigator, Funding: 300,000 yuan.
• 2022 - 2027: Key Research and Development Program of the Ministry of Science and Technology, Regulation Mechanisms and Intervention Strategies of Leukemia on Hematopoietic Stem Cells and Microenvironment, Project No. 2022YFA1103302, Ongoing, Project Leader, Funding: 6.2624 million yuan.
• 2022 - 2027: Key Research and Development Program of the Ministry of Science and Technology, Mechanisms of Mesenchymal Stem Cells in Maintaining Tissue Homeostasis and Disease Occurrence and Targeted Intervention Therapies, Project No. 2022YFA1104100, Ongoing, Core Member.
• 2022 - 2025: National Natural Science Foundation of China General Project, Mechanistic Study on the Regulation of Sirt6 in the Fate Determination of Osteogenic Differentiation and Hematopoietic Support Function Subsets of Bone Marrow Mesenchymal Stem Cells, Project No. 82170112, Ongoing, Principal Investigator, Funding: 550,000 yuan.
• 2019 - 2021: National Natural Science Foundation of China Excellent Young Scientists Fund, Hematopoietic Stem Cell Bone Marrow Microenvironment, Project No. 81822001, Completed, Principal Investigator, Funding: 1.3 million yuan.
• 2019 - 2021: Guangdong Provincial Key Area R & D Program, Lineage Hierarchy, Microenvironment Regulation and Preparation Strategies of Hematopoietic Stem Cells, Project No. 2019B020234002, Ongoing, Principal Investigator, Funding: 3 million yuan.
• 2018 - 2022: Key Research and Development Program of the Ministry of Science and Technology, Functional Identification, Isolation, Preparation and Therapeutic Efficacy Evaluation of Mesenchymal Stem Cell Subsets, Project No. 2018YFA0107200, Ongoing, Core Member.
• 2018 - 2020: National Natural Science Foundation of China Major Research Plan, Molecular Mechanisms of TGFβ-SHP-1 Signaling Pathway Regulating Hematopoietic Stem Cell Senescence, Project No. 91749106, Completed, Principal Investigator, Funding: 600,000 yuan.
• 2017 - 2022: Guangdong Pearl River Talent Plan Young Talents Team, New Technology Research and Development for iPS Cell-derived Tissue Construction and Treatment of Major Diseases, Core Member, Ongoing.
• 2017 - 2021: Key Research and Development Program of the Ministry of Science and Technology, Microenvironment Regulation and Preparation Strategies of Mesoderm-derived Tissue Stem Cells, Project No. 2017YFA0103403, Completed, Project Leader, Funding: 8.23 million yuan.
• 2017 - 2020: Key Cultivation Plan of Sun Yat-sen University, Completed, Principal Investigator.
• 2017 - 2020: National Natural Science Foundation of China General Project, Study on the Role of WNT Signaling Pathway in Bone Marrow Microenvironment in Promoting Hematopoietic Stem Cell Regeneration and Repair, Project No. 81670101, Completed, Principal Investigator, Funding: 550,000 yuan.
• 2011 - 2013: National Natural Science Foundation of China Youth Project, The Relationship between C/EBPα Phosphorylation and Ubiquitination Degradation and Its Role in Leukemia Cell Apoptosis, Project No. 81000214, Completed, Principal Investigator.

Awards and Honors

1. Top Ten Research Progresses in Chinese Hematology in 2023, /zh-hans/article/10541
2. Top Ten Research Progresses in Chinese Hematology in 2022, /zh-hans/article/9819