Tutor Qualification:Doctoral supervisor

Department:Department of human Anatomy

E-mail：linxian3@mail.sysu.edu.cn

Mailing address:Department of Anatomy, Zhongshan Medical College, Zhongshan University, 74 Zhongshan Second Road, Guangzhou

Research direction:Research direction 1: Functional study of Parkinson's disease (PD) related genes and proteins. The related genes with dominant familial heritability in Parkinson's disease are alpha-synuclein and LRRK2. We demonstrated for the first time that LRRK2 can specifically exacerbate the pathological changes induced by alpha-synuclein in vivo, and clarified the molecular pathological mechanism of its action. The current research content is as follows: 1. Explore the signal conduction pathway of the interaction between LRRK2 and alpha-synuclein. 2. Taking alpha-synuclein, the core pathological protein of PD, as the target, to study the molecular interaction mechanism between other pathological proteins of PD (such as tau) and them. Research direction 2: Epigenetic research on PD. Our aim is to study the differences in epigenetic modification of dopamine neurons in different parts of the midbrain and their causes, so as to explain the pathogenesis of PD. Research direction 3: The role of immune inflammation in the development of PD.

Personal Profile

I obtained my Bachelor's degree from Fujian Medical University in 1995 and my Master's degree in 2000. I then earned my Doctor of Medicine degree from the Zhongshan School of Medicine, Sun Yat-sen University (formerly known as Zhongshan Medical University) in 2003. From 1995 to 2000, I worked as an assistant teacher in the Anatomy Teaching and Research Section of Fujian Medical University. I served as a lecturer in the Department of Anatomy at Sun Yat-sen University from 2003 to 2004. I conducted postdoctoral research at the National Institutes of Health (NIH) in the United States from 2004 to 2009. I was a Research Fellow at the NIH from 2009 to 2010. In October 2010, I returned to China to work as an introduced talent at Sun Yat-sen University.

Academic Achievements
Academic Works and Textbooks

(1) Zheng M, Jiao L, Tang X, Xiang X, Wan X, Yan Y, Li X, Zhang G, Li Y, Jiang B, Cai H, Lin Xian*. Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression. FASEB J, Published online Apr 19, 2017.

(2) Mo M, Xiao Y, Huang S, Cen L, Chen X, Zhang L, Luo Q, Li S*, Yang X*, Lin X*, Xu P*. Oncotarget, 2017, 8(1):15-28.

(3)Li X, Zhang G, Nie Q, Wu T, Jiao L, Zheng M, Wan X, Li Y, Wu S, Jiang B, Xiang X, Duan J, Lin X*. Baicalein blocks α-synuclein secretion from SN4741 cells and facilitates α-synuclein polymerization to big complex. Neuroscience Letter, 2017, Jul 1;655:109-114.

(3) Xian Lin, Loukia Parisiadou, Carmelo Sgobio, Guoxiang Liu, Jia Yu, Lixin Sun, Hoon Shim, Xing-Long Gu, Jing Luo, Cai-Xia Long, Jinhui Ding, Yolanda Mateo, Patricia H. Sullivan, Ling-Gang Wu, David S. Goldstein, David Lovinger, and Huaibin Cai.Conditional Expression of Parkinson's Disease-Related Mutant α-Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1.The Journal of Neuroscience, 2012, 32(27):9248-64.

(4) Xian Lin, Loukia Parisiadou, Xing-Long Gu, et al. Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathologyalpha-synuclein. Neuron, 2009,64:807-827.(First featured papers with first preview).

(5) Chen Lai#, Xian Lin#, Jayanth Chandran, et al. The G59S mutation in p150 causes dysfunction in mice. The Journal of Neuroscience, 2007, 27(51):13982-13900.(co-first author, cover introduction).

(6) Xian Lin, Hoon Shim, Huaibin Cai. Deficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1(G93A) transgenic mice. Neurobiol Aging, 2007, 28(10):1628-30.

(7) Cai H, Lin X, Xie C, et al. Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress. The Journal of Neuroscience, 2005, 25(33):7567-74.

(8) Chandran JS, Lin X, Zapata A, et al. Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiol Dis, 2008, 29(3):505-14.

(9) Cai H, Shim H, Lai C, Xie C, Lin X, Yang WJ, Chandran J.ALS2/alsin knockout mice and motor neuron diseases. Neurodegener Dis, 2008; 5(6):359-66.

(10) Loukia Parisiadou, Chengsong Xie, Hyun Jin Cho, Xian Lin, Xing-Long Gu, Cai-Xia Long, Evy Lobbestael, Veerle Baekelandt, Jean-Marc Taymans, Lixin Sun, and Huaibin Cai Phosphorylation of Ezrin-Radixin-Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis. The Journal of Neuroscience, 2008, 29(44):13971-80.

(11) Luo J#, Sun L, Lin X, Liu G, Yu J, Parisiadou L, Xie C, Ding J, Cai H*. A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons. Hum Mol Genet, 2014, 23(24):6567-74.

(12)Parisiadou L#*, Yu J#, Sgobio C#, Xie C, Liu G, Sun L, Gu XL, Lin X, Crowley NA, Lovinger DM, Cai H*. LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Nat Neurosci, 2014, 17(3):367-76.

Academic Affiliations

  • Member of the Society for Neuroscience (USA)
  • Member of the Chinese Neuroscience Society
  • Member of the Chinese Biophysical Society
  • Member of the Chinese Anatomical Society
  • Executive Committee Member of the Neuropharmacology Professional Committee of the Guangdong Pharmacological Society