Personal Profile

Graduated from the Department of Clinical Medicine, Bengbu Medical College, Anhui Province in 1994, obtaining a Bachelor of Medicine degree. In 1997, received a Master's degree in Parasitology from Sun Yat-sen University of Medical Sciences. In the same year, stayed at the university to work in the Department of Parasitology Teaching and Research. In 2000, conducted doctoral dissertation research at Tufts University in the United States in the form of joint training and obtained a Doctor of Medicine degree in 2001. From 2001 to 2003, carried out postdoctoral research at Tufts University. From 2003 to 2010, engaged in scientific research work at the University of Illinois at Chicago in the United States and served as an Assistant Research Professor at the university in 2006. In 2010, as an overseas talent introduced by Sun Yat-sen University, started working at the Zhongshan School of Medicine, appointed as a professor and doctoral supervisor at Sun Yat-sen University.

Academic Achievements

Important Academic Research Achievements and Contributions

The main research focuses on the pathogenic mechanisms of Clonorchis sinensis, including the occurrence and development mechanisms of liver fibrosis and cholangiocarcinoma induced by liver flukes. It explores the specific protein molecules in the secretory and excretory products of Clonorchis sinensis that activate hepatic stellate cells through direct or indirect pathways to cause liver fibrosis and studies the specific molecular mechanisms by which they cause liver fibrosis. In addition, the relationship between Clonorchis sinensis infection and cholangiocarcinoma is also an important research content. The molecular mechanisms of Plasmodium falciparum invasion into human red blood cells are also studied, laying a foundation for the development of malaria vaccines and anti-malaria drugs. The research team has successively received funding from multiple national and provincial/ministerial-level funds such as the National Key Basic Research Development Program (973 Program), the National Key R & D Program, the National Natural Science Foundation of China, and the Guangdong Provincial Natural Science Foundation. The relevant research results have been published in journals such as PNAS, JBC, Blood, Frontiers in Biology, and Parasites & Vectors. So far, more than 70 SCI papers have been published, serving as the chief editor or co-author of multiple monographs, cultivating many doctoral and master's students, applying for multiple invention patents, and obtaining authorization for 3 patents. The team has a good foundation in parasitology research and has gained a certain influence both at home and abroad. Three provincial/ministerial-level scientific research awards have been received. Served as the chief editor or co-author of multiple textbooks and monographs.

Textbooks and Monographs

Some of the papers published in recent years:

(1) He Q.(#), Pan X.(#), Yin Y., Xu A., Yi X., Wu Y.(*), Li X.(*). Clonorchis sinensis granulin promotes malignant transformation of human biliary epithelial cells by interacting with M2 macrophages via regulating STAT3 phosphorylation and MEK/ERK pathway, Parasites & Vectors. 2023, 16: 139.  

(2) He Q.(#), Yin Y.(#), Pan X., Wu Y.(*), Li X.(*). Albendazole-induced autophagy blockade contributes to elevated apoptosis in cholangiocarcinoma cells through AMPK/mTOR activation, Toxicol Appl Pharmacol, 2022, 454: 116214. 

(3) Yin Y. (#), He Q.(#), Pan X., Liu Q., Wu Y.(*),  Li X.(*), Predicting Current Potential Distribution and the Range Dynamics of Pomacea canaliculata in China under Global Climate Change, Biology, 2022, 11(1): 110

(4) Wang C.(#), He Q.(#), Yin Y., Wu Y.(*), Li X.(*), Clonorchis sinensis Granulin Promotes Malignant Transformation of Hepatocyte Through EGFR Mediated RAS/MAPK/ERK and PI3K/ Akt Signaling Pathways, Frontiers in Cellular and Infection Microbiology, 2021, 11: 734750

(5) Wu Y., He Q., Shang M., Yin Y.,  Li Y., Du X.,  Li X.*, The NF-κB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis, Parasites & Vectors, 2021, (14): 152-160 

(6) Huang H., He Q., Guo B., Xu X., Wu Y., Li X* . Progress in Redirecting Antiparasitic Drugs for Cancer Treatment. Drug Des Devel Ther. 2021,15:2747-2767.

(7) Wang C.(#), Lei H.(#), Tian Y., Shang M., Wu Y., Li Y., Zhao L., Shi M., Tang X., Chen T., Lv Z., Huang Y., Tang X., Yu X.(*), Li X.(*), Clonorchis sinensis granulin: identification, immunolocalization, and function in promoting the metastasis of cholangiocarcinoma and hepatocellular carcinoma, Parasites & Vectors, 2017, 10(1): 262- 273 

(8) Wu Y.,  Li Y., Shang M., Jian Y., Wang C., Bardeesi A.,  Li Z., Chen T., Zhao L., Zhou L.,  He A., Huang Y., Lv Z., Yu X., Li X.*, Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling, Parasites & Vectors, 2017, 10(1): 147-158 

(9)王彩琴(#)，余新炳，李学荣(*),华支睾吸虫感染与胆管癌发生发展关系的研究进展，中国寄生虫学与寄生虫病杂志，2015，（02）：142-146。

(10) Ren M.(#), He L.，Huang Y.，Mao Q.，Li S.，Qu H.，Bian M.，Liang P.，Chen X.，Ling J.，Chen T.，Liang C.，Wang X.，Li X.(*), Yu X.(*), Molecular characterization of Clonorchis sinensis secretory myoglobin: delineating its role in anti-oxidative survival，Parasit Vectors，2014，7：250。

(11) He L. (#) , Ren M.，Chen X.，Wang X.，Li S.，Lin J.，Liang C.，Liang P.，Hu Y.，Lei H.，Bian M.，Huang Y.，Wu Z.，Li X.(*)，Yu X. (*), Biochemical and immunological characterization of annexin B30 from Clonorchis sinensis excretory/secretory products，Parasitology Research，2014，113（7）：2743-55。

(12) Bian M.(#) , Li S.，Wang X.，Xu Y.，Chen W.，Zhou C.，Chen X.，He L.，Xu J.，Liang C.，Wu Z.，Huang Y.，Li X.(*) ，Yu X. (*) , Identification, immunolocalization, and immunological characterization of nitric oxide synthase-interacting protein from Clonorchis sinensis，Parasitology Research，2014，113（5）：1749-57。

Research Projects

Research Projects/Topics Presided over or Participated in Recent Years

• ​Guangdong Provincial Department of Science and Technology, Guangdong Natural Science Foundation General Project
  • Project No. 2023A1515010955: "Research on the Role and Mechanism of Clonorchis sinensis Granulin Protein (CsGRN) in Inducing Malignant Transformation of Mouse Biliary Tract", from January 2023 to December 2025, with a fund of 100,000 yuan. In progress. (Principal Investigator)
• ​Guangdong Provincial Department of Science and Technology, Guangdong Natural Science Foundation General Project
  • Project No. 2022A1515012560: "Research on the Mechanism by which CRISPR/Cas9 Knockout of the CSsPLA2 Gene Alleviates Liver Fibrosis after Clonorchis sinensis Infection", from January 2022 to December 2024, with a fund of 100,000 yuan. In progress. (Participant)
• ​Ministry of Science and Technology, Key R & D Program
  • Project No. 2021YFC2300800: "Research on the Pathogenic Mechanisms and Prevention and Control Intervention Technologies of Important Parasitic Infections Threatening Humans", from December 2021 to November 2024, with a fund of 18 million yuan. In progress. (Participant)
• ​Guangzhou Science and Technology Bureau, Guangzhou Science and Technology Plan Project
  • Project No. 202201011723: "Research on the Mechanism of the Anti-cholangiocarcinoma Effect of the Antiparasitic Drug Albendazole", from April 2022 to March 2024, with a fund of 50,000 yuan. In progress. (Principal Investigator)
• ​Ministry of Science and Technology, Key R & D Program
  • Project No. 2020YFC1200100: "Research and Development of Key Technologies and Products for Detection and Prevention and Control of Major Invasive Vectors and Pathogens", from July 2020 to June 2023, with a fund of 18.19 million yuan. In progress. (Participant)
• ​Guangdong Provincial Department of Science and Technology, Guangdong Natural Science Foundation General Project
  • Project No. 2019A1515010583: "Molecular Mechanism of the Role of Clonorchis sinensis Granulin Protein in Cholangiocarcinoma Induced by Clonorchis sinensis Infection", from October 2019 to September 2022, with a fund of 100,000 yuan. Completed. (Principal Investigator)
• ​Ministry of Science and Technology, Emergency Management Project of the National Natural Science Foundation
  • Project No. 81641094: "Research on the Molecular Mechanism by which Clonorchis sinensis Secretory Phospholipase A2 Activates Hepatic Stellate Cells", from January 2017 to December 2017, with a fund of 100,000 yuan. Completed. (Principal Investigator)
• ​Ministry of Science and Technology, Key R & D Program
  • Project No. 2016YFC1202000: "Dynamic Distribution and Resource Bank Construction of Important Tropical Disease-related Invasive Vectors and Their Pathogens", from July 2016 to December 2018, with a fund of 12.83 million yuan. Completed. (Participant)

Academic Part-time Positions

• Vice President of the Guangdong Parasitology Society
• Vice President of the Guangdong Zoological Society
• Member of the Local Disease Society of the Chinese Preventive Medicine Association
• Member of the American Society of Parasitology
• Reviewer for journals such as Blood, Parasites & Vectors, Molecular and Biochemical Parasitology, and Parasitology Research.