Nuclear factor NF - κ B is a multifunctional nuclear transcription factor that plays a central regulatory role in physiological and pathological processes of the body. Numerous epidemiological and experimental studies have demonstrated that the NF - κ B signaling pathway is highly sustained and activated in various tumors, and is involved in multiple important processes of tumor occurrence and development, such as anti apoptosis, pro proliferation, angiogenesis, and invasion and metastasis. Therefore, taking the regulatory mechanism of the tumor NF - κ B signaling pathway as the research entry point, searching and identifying key regulatory nodes at different levels of this pathway not only adds new theoretical basis for tumor occurrence and development, but also provides important target sites for the development of tumor therapeutic drugs.