Personal profile

Associate Professor, Sun Yat-sen Medical College, Howard Stanford University. Hughes Medical Institute (HHMI) Visiting scholar. In June 2005, he graduated from the Department of Forensic Medicine, Sun Yat-sen School of Medicine, Sun Yat-sen University, and won the title of \"Outstanding Graduate of Sun Yat-sen University\", and obtained the postgraduate qualification without examination. In September 2005, he studied for postgraduate study in the study of stroke ion channel in Sun Yat-sen School of Medicine, Sun Yat-sen University, and graduated in June 2010 with the degree of Doctor of Medicine. In July 2010, he was a lecturer in the Department of Forensic Medicine of Sun Yat-sen Medical College. In 2013, he was awarded the tutor of postgraduate students and then promoted to associate professor. He was an expert in the Forensic Expert Center of Sun Yat-sen University, a national forensic expert institution. He has published 20 SCI papers (5 IF>5), including 7 corresponding authors or co-corresponding authors, 5 first or co-first authors, hosted 5 scientific research projects such as the National Natural Science Foundation, and won the first prize of the Young Academic Award of Sun Yat-sen School of Medicine, Sun Yat-sen University in 2013. The second prize of Natural Science of the Ministry of Education in 2013 and the second prize of China Medical Science and Technology Award in 2014 (the 6th finisher).

Academic achievement

Acting Grants:

1. 2014～2017 Role of ClC-3 in hydrogen peroxide-induced mitophagy in artery smooth muscle cells. National Natural Science Foundation of China, 230,000 RMB, Principal Investigator (Number: 81300106)
2. 2013～2017 Mechanism of ClC-3 in regulating hypertensive cerebrovascular remodeling. Provincial Natural Science Fund Project of Guangdong, 30,000 RMB, Principal Investigator (Number: S2012040006519)
3. 2012～2015 Mechanism of ClC-3 chloride channels in regulating hypertensive cardiac hypertrophy induced by Angiotension-Ⅱ in mice. Fundamental Research Funds for the Central Universities, 150,000 RMB, Principal Investigator (Number: 11YKPY06)

Representative Publications:

1. Wang, Xiao-Guang#，Tao, Jing#，Ma, Ming-Ming#，Tang, Yong-Bo，Zhou, Jia-Guo，Guan, Yong-Yuan*，Tyrosine 284 phosphorylation is required for ClC-3 chloride channel activation in vascular smooth muscle cells，Cardiovasc Res,，2013，98（3）：469-478（Impact factor:6.02）
2. Asim M, Wang B, Hao B, Wang XG*. Ketamine for post-traumatic stress disorders and it's possible therapeutic mechanism. Review. Neurochem Int. 2021;146:105044. doi: 10.1016/j.neuint.2021.105044. （Impact factor:3.88）
3. Chen YF#, Chen ZX#, Wang RH, Shi YW, Xue L, Wang XG*, Zhao H*. Knockdown of CLC-3 in the hippocampal CA1 impairs contextual fear memory. Prog Neuropsychopharmacol Biol Psychiatry. 2019;89:132-145. （Impact factor:4.36）
4. Asim M#, Hao B#, Yang YH, Fan BF, Xue L, Shi YW*, Wang XG*, Zhao H. Ketamine Alleviates Fear Generalization Through GluN2B-BDNF Signaling in Mice. Neurosci Bull. 2020 Feb;36(2):153-164. （Impact factor:4.32）
5. Liu, Yu-Jie#，Wang, Xiao-Guang#，Tang, Yong-Bo#，Chen, Jing-Hui，Lv, Xiao-Fei，Zhou, Jia-Guo*，Guan,Yong-Yuan*，Simvastatin Ameliorates Rat Cerebrovascular Remodeling During Hypertension via Inhibition of Volume-Regulated Chloride Channel，HYPERTENSION，2010，56（3）：445-452（Impact factor:6.93）
6. Zeng, Jia-Wei#, Wang, Xiao-Guang#，Ma, Ming-Ming#，Lv, Xiao-Fei，Liu, Jie，Zhou, Jia-Guo，Guan,Yong-Yuan*，Integrin beta3 mediates cerebrovascular remodelling through Src/ClC-3 volume-regulated Cl- channel signalling pathway.，Br J Pharmacol,，2014，171（13）：3158-3170（Impact factor:5.04）
7. Fang Liu#，Qing-Hua Cao#，De-Jian Lu#，Bin Luo，Xiao-Fang Lu，Rong-Cheng Luo*，Xiao-Guang Wang*，TMEM16A overexpression contributes to tumor invasion and poor prognosis of human gastric cancer through TGF-βsignaling，Oncotarget，2015，Feb.Epub ahead of print. （Impact factor:6.61）
8. Shi YW#, Fan BF, Xue L, Wang XG*, Ou XL*. Fear renewal activates cyclic adenosine monophosphate signaling in the dentate gyrus.Brain Behav. 2019;9(8):e01280.（Impact factor:2.09）
9. Tong ZT#, Cai MY#, Wang XG, Kong LL, Mai SJ, Liu YH, Zhang HB, Liao YJ, Zheng F,Zhu W, Liu TH, Bian XW, Guan XY, Lin MC, Zeng MS, Zeng YX, Kung HF, Xie D.EZH2 supports nasopharyngeal carcinoma aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin. Oncogene. 2012 Feb;31:583-94（Impact factor:7.36)
10. Li, Shi-Yang#，Wang, Xiao-Guang#，Ma, Ming-Ming，Liu, Yun，Du, Yan-Hua，Lv, Xiao-Fei，Zhou,Jia-Guo，Tang, Yong-Bo*，Guan, Yong-Yuan*，Ginsenoside-Rd potentiates apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells through the mitochondrial pathway，Apoptosis，2012，17（2）：113-120（Impact factor:4.32）