Personal Profile

Lei Wanlong, Doctor/Postdoctor, Professor/Doctoral Supervisor, Research Associate in Neuroanatomy at the University of Tennessee College of Medicine, Member of the Society for Neuroscience (SFN, No. 100013344). Graduated from Xi'an Medical University in 1994 and 1997 respectively, obtaining a Master of Medicine and a Doctor of Medicine degree. Completed his postdoctoral research at Zhongshan Medical University in 1999. During this period, he has been engaged in experimental research on the pathological mechanisms of cerebral ischemic injury and immunointervention therapy, and has published more than 30 papers in core domestic journals.

From 2001 to 2005, during his postdoctoral research at the University of Tennessee College of Medicine, he was engaged in experimental research on the neurobiology of basal ganglia connections and the pathological mechanisms of Huntington's disease. He confirmed the existence of two types of corticostriatal neurons with different morphological characteristics in the cerebral cortex, as well as the specific connections between them and the projection neurons of the direct and indirect pathways in the striatum. At the same time, he discovered the specificity of thalamostriatal projections and the interspecies differences in corticostriatal and thalamostriatal projections. He systematically studied the behavioral changes and pathological changes of striatal neurons in R6/2 transgenic model mice of Huntington's disease. These results were published in journals such as J Neurosci, J Comp Neurol, Neurobiol Dis and J Chem Neuroanat. Additionally, five abstracts were presented at international neuroscience conferences in the United States.

Academic Achievements

Published Papers

1. Single-cell RT-PCR,in situ hybridization histochemismical,and immunohistochemical studies of SP and ENK co-occurrence in striatal projection neurons in rats. J Chem Neuroanat,2006;31；178
2. Differential morphology of pyramidal tract-type and intratelencephalically projection-type corticostriatal neurons and their intrastriatal terminals in rats. J Comp Neurol, 2003; 457:420-440
3. Increased calbindin-D28k immunoreactivity in striatal projection neurons of R6/2 Huntington’s disease transgenic mice. Neurobiology of Disease.2005,20(3);907-917
4. Evidence for differential cortical input to direct pathway versus indirect pathway striatal projection neurons in rats. Journal of Neuroscience, 2004; 24(38):8289-8299

Others

1. Differential excitatory input to direct pathway and indirect pathway striatal projection neurons in rhesus monkeys. Soc Neurosci, 2005
2. Differential response of direct pathway versus indirect pathway striatal projection neurons to activation of input from intratelencephalically projecting cortical neurons. Soc Neurosci, 2005; 
3. Thalamic input to striatonigral and striatopallidal projection neurons in rats. Soc Neurosci, 2004
4. Differential localization of D1 and D2 doparnine receptors on striatal projection neurons types in rats identified by retrograde labeling. Soc Neurosci, 2004
5. Differential contical input to Str-SNr and Str-GPe projection neurons in rats. Soc Neurosci,2003