Personal Profile

Sun Xi, female,  Professor and Doctoral Supervisor at the Zhongshan School of Medicine, Sun Yat-sen University. Her research mainly focuses on the interaction between pathogens and hosts. Her research directions include:
(1) The role and mechanism of exosomes derived from pathogens in pathogenic immune and pathological damage;
(2) The therapeutic effects and mechanisms of host immune cell changes mediated by immunoregulatory molecules derived from pathogens on autoimmune diseases;
(3) The relationship between invasive alien vector organisms and biosafety.

Her research work has been supported by projects such as the "863" Young Scientists Project, the National Natural Science Foundation of China, the China Postdoctoral Science Foundation, the Doctoral Program Fund of the Ministry of Education, the Guangdong Provincial Natural Science Foundation, and the "Pearl River Science and Technology New Star" project of the Guangzhou Science and Technology Bureau. Her research achievements, as the first author or corresponding author, have been published in more than 40 high-level papers in journals such as J Extracell Vesicles, Mol Ther, Bioeng Transl Med, Theranostics, Cancer letter, J Neuroinflammation, Front Immunology, and PLoS Negl Trop Dis.

Academic Achievements

Important Academic Research Achievements and Contributions

• ​National Natural Science Foundation General Project, No. 82272361: "Research on the Mechanism by which Schistosoma japonicum Infection Upregulates Sema4D to Promote HSC Activation through the PlexinB1-C/EBPβ-ALDH1A1 Axis Regulating Retinol Metabolism", from January 2023 to December 2026, with a fund of 520,000 yuan. In progress. (Principal Investigator)
• ​Guangdong Provincial Natural Science Foundation, No. 2021A1515010976: "Research on the Mechanism of Nissle 1917-α-hemolysin-Sj16 Engineered Bacteria in Treating Inflammatory Bowel Disease", from January 2021 to December 2023, with a fund of 100,000 yuan. In progress. (Principal Investigator)
• ​Guangdong Provincial Natural Science Foundation, No. 2019A1515012068: "Research on the Mechanism by which the Small Molecule Hexa Derived from Angiostrongylus cantonensis Synergizes with IL-13 to Promote the Increase of Chil3l3", from October 2019 to September 2022, with a fund of 100,000 yuan. In progress. (Principal Investigator)
• ​National Key R & D Program, No. 2021YFC2300800: "Research on the Pathogenic Mechanisms and Prevention and Control Intervention Technologies of Important Parasites Threatening Humans", from December 2021 to November 2024, with a fund of 18.08 million yuan. In progress. (Participant)
• ​NSFC-RGC Cooperative Project, No. 82161160343: "Research on the Population Genomics of the Alien Organism Angiostrongylus cantonensis in the Guangdong-Hong Kong-Macao Greater Bay Area and the Risk Assessment of Its Transmission of Imported Schistosomiasis", from January 2022 to December 2025, with a fund of 1 million yuan. In progress. (Second Participant)
• ​Guangdong Key Area R & D Program, No. 2022B1111030002: "Research and Development of Key Technologies for the Prevention and Control of Important Alien Vector Organisms", from June 2022 to June 2025, with a fund of 5 million yuan. In progress. (Participant)
• ​Guangzhou Science and Technology Innovation Talent Special Project - Pearl River Science and Technology New Star, No. 201710010030: "Research on the Mechanism by which the Antigen of Angiostrongylus cantonensis Upregulates IL-13-mediated High Expression of Chil3 in Macrophages and the Screening and Identification of Key Parasitic Molecules", from January 2017 to December 2019. Completed. (Principal Investigator)
• ​National Key R & D Program, No. SQ2016YFSF120003: "Research on the Biological Characteristics of Invasive Vector Organisms and Their Pathogens Related to the Transmission of Important Tropical Diseases", from July 2016 to December 2018, with a fund of 12.77 million yuan. Completed. (Participant, Second Participant of Topic 3)
• ​National Natural Science Foundation General Project, No. 81572014: "Research on the Regulatory Role and Mechanism of Exosomes (Exosome) of Schistosoma japonicum on Host Immune Responses", from January 2016 to December 2019, with a fund of 600,000 yuan. Completed. (Participant, Second Participant)
• ​863 Fund - Young Scientists Project, No. 2015AA020934: "Early Evaluation of the Pharmacodynamics, Pharmacokinetics and Safety of the Immunoregulatory Molecule Sj16 Derived from Parasites", from January 2015 to December 2017, with a fund of 1.27 million yuan. Completed. (Principal Investigator)
• ​National Natural Science Foundation Young Scientists Fund, No. 81201309: "Research on the Signaling Pathway and Molecular Mechanism by which the 16 kDa Protein of Schistosoma japonicum Regulates High IL-10 Expression in Dendritic Cells (DCs)", from January 2013 to December 2015, with a fund of 230,000 yuan. Completed. (Principal Investigator)
• ​National Natural Science Foundation General Project, No. 81271855: "The Role and Mechanism of Microglia in Angiostrongyliasis", from January 2013 to December 2016, with a fund of 600,000 yuan. Completed. (Participant, Second Participant)
• ​National Natural Science Foundation - NIH Cooperative Project, No. 81110340: "The Immune Response of Aged Host T Cells to Schistosoma Infection", from January 2013 to December 2013, with a fund of 300,000 yuan. Completed. (Participant, Second Participant)
• ​National Natural Science Foundation - Cross-Strait Cooperative Project, No. 81261160324: "Experimental Research on the Phylogenetic Relationship, Pathogenic Mechanism, Molecular Diagnostic Targets and Treatment of Angiostrongylus cantonensis between the Two Sides of the Taiwan Strait", with a fund of 2.5 million yuan, from January 2013 to December 2015. Completed. (Participant, Fifth Participant)
• ​China Postdoctoral Science Foundation, No. 2011M501363: "Screening and Identification of the Structural Domains and Interaction Target Proteins of the Immunoregulatory Role of rSj16", from January 2012 to December 2013, with a fund of 30,000 yuan. Completed. (Principal Investigator)
• ​Special Scientific Research Fund for Doctoral Programs of Higher Education Institutions (New Teacher Category), No. 20120171120049: "Research on the Signaling Pathway and Molecular Mechanism by which the 16 kDa Protein of Schistosoma japonicum Regulates High IL-10 Expression in Dendritic Cells", from January 2013 to December 2015, with a fund of 40,000 yuan. Completed. (Principal Investigator)
• ​Guangdong Provincial Natural Science Foundation (Doctoral Startup Project), No. S2012040007256: "Research on the Molecular Mechanism by which the 16 kDa Protein of Schistosoma japonicum Regulates High IL-10 Expression in Dendritic Cells", from January 2013 to December 2014, with a fund of 30,000 yuan. Completed. (Principal Investigator)

Academic Works and Textbooks

Representative Articles in the Past Five Years:

1. Wang L#, Zhu Z#, Liao Y, Zhang L, Yu Z, Yang R, Wu J, Wu Z*, Sun X*. Host liver-derived extracellular vesicles deliver miR-142a-3p induces neutrophil extracellular traps via targeting WASL to block the development of Schistosoma japonicum. Mol Ther. 2022 Mar 26:S1525-0016(22)00176-9. doi: 10.1016/j.ymthe.2022.03.016.（IF=12.91）
2. Wang L, Liao Y, Yang R, Zhu Z, Zhang L, Wu Z, Sun X. An engineered probiotic secreting Sj16 ameliorates colitis via Ruminococcaceae/butyrate/retinoic acid axis. Bioeng Transl Med. 2021 Apr 2;6(3):e10219. doi: 10.1002/btm2.10219. PMID: 34589596; PMCID: PMC8459592..（IF=10.68）
3. Wang LF#, Liao Y#, Yang RB#, Yu ZL#, Zhang LC, Zhu ZF, Wu XY, Shen J, Liu JH, Xu L, Wu ZD*, Sun X*. Sja-miR-71a in Schistosome egg-derived extracellular vesicles suppresses liver fibrosis caused by schistosomiasis via targeting semaphorin 4D. J Extracell Vesicles. 2020 Jul 9;9(1):1785738.（IF=17.337）
4. Wang L, Xie H, Xu L, Liao Q, Wan S, Yu Z, Lin D, Zhang B, Lv Z, Wu Z, Sun X. rSj16 has protective effect on the severity of DSS- induced colitis by inhibits PPAR-α signaling pathway. Theranostics. 2017 Aug 15;7(14):3446-3460. （IF=11.6）
5. Wan S#, Sun X#, Wu F#, Yu Z, Wang L, Lin D, Li Z, Wu Z*, Sun X*.Chi3l3: a potential key orchestrator of eosinophil recruitment in meningitis induced by Angiostrongylus cantonensis. J Neuroinflammation. 2018 Feb 2;15(1):31. doi: 10.1186/s12974-018-1071-2.（IF=9.587）
6. Wan S#, Sun X#, Tang W, Wang L, Wu Z, Sun X. Exosome-Depleted Excretory-Secretory Products of the Fourth-Stage Larval Angiostrongylus cantonensis Promotes Alternative Activation of Macrophages Through Metabolic Reprogramming by the PI3K-Akt Pathway. Front Immunol. 2021 Jul 23;12:685984. doi: 10.3389/fimmu.2021.685984.（IF=8.786）
7. Du S#, Sun X#, Zhang J, Lin D, Chen R, Cui Y, Xiang S, Wu Z*, Ding T*. Metagenome-Assembled Genomes Reveal Mechanisms of Carbohydrate and Nitrogen Metabolism of Schistosomiasis-Transmitting Vector Biomphalaria Glabrata. Microbiol Spectr. 2022 Mar 7:e0184321. doi: 10.1128/spectrum.01843-21. Epub ahead of print. PMID: 35254167. （IF=9.032）
8. Tang YL#, Sun X#, Huang LB#, Liu XJ#, Qin G, Wang LN, Zhang XL, Ke ZY, Luo JS, Liang C, Peng CJ, Tang WY, Li Y, Huang W, Luo XQ*, Deng W*.Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways. Cancer Lett. 2019 Feb 28;443:167-178. doi: 10.1016/j.canlet.2018.11.037. Epub 2018 Dec 11.（IF=9.756）
9. Feng Y, Feng F, Zheng C, Zhou Z, Jiang M, Liu Z, Xie F, Sun X*, Wu Z*.Tanshinone IIA attenuates demyelination and promotes remyelination in A. cantonensis-infected BALB/c mice. Int J Biol Sci. 2019 Aug 19;15(10):2211-2223.（IF=10.750）
10. Lin D#, Zeng X#, Sanogo B, He P, Xiang S, Du S, Zhang Y, Wang L, Wan S, Zeng X, Yang Y, Lv Z, Liang Y, Deng Z, Hui JH, Yuan D, Ding T, Wu Z*, Sun X*. The potential risk of Schistosoma mansoni transmission by the invasive freshwater snail Biomphalaria straminea in South China. PLoS Negl Trop Dis. 2020 Jun 8;14(6):e0008310