Personal profile

Associate Professor, doctoral supervisor, Deputy Director of the Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, training object of the fourth batch of school-level thousand and ten projects in Guangdong Province, standing member of the Cardiovascular Pharmacology Committee of Guangdong Pharmacological Society, member of the cardiovascular Professional Committee of Guangdong Pathophysiological Society, deputy chairman of the Youth Committee of the cardiovascular Professional Committee of Guangdong Pathophysiological Society, Thesis review expert of Degree Center of Ministry of Education, National Natural Science Foundation communication review expert, science and technology review expert of Guangdong Province. In 1999, he graduated from the National Biology Talent Training Base Class of the School of Life Sciences of Wuhan University with a bachelor's degree. In 2002, he received a master's degree in Biochemistry and molecular biology from Fuwai Hospital of Peking Union Medical University. He received his Ph.D. degree in Pathology and pathophysiology from Sun Yat-sen University in 2008. From 2008 to 2009, he visited the Cardiovascular Research Center of the University of Manchester School of Medicine to study the molecular mechanism of vascular calcification. He has been engaged in the research of cardiovascular disease mechanism for a long time, and has published more than 20 SCI papers in Aging Cell, ATVB, Free Radic Biol Med, J Pathol, Lab Invest, Int J Cardiol and other journals. For the first time, the mechanism of myocardial autophagy involved in adriamycin-induced heart failure was elucidated, and the paper has been cited 187 times. He has presided over 4 National Natural Science Foundations and 5 provincial and ministerial funds, and served as the main academic backbone of a 973 program and the reviewer of journals such as J Mol Endocrinol.

Academic achievement

1. Lu L#, Ye Y#, Chen Y, Feng L, Huang J, Liang Q, Lan Z, Dong Q, Liu X, Li Y, Zhang X, Ou JS, Chen A*, Yan J*. Oxidized phospholipid POVPC contributes to vascular calcification by triggering ferroptosis of vascular smooth muscle cells.  FASEB J, 2024;38(7):e23592.
2. Lu L#, Li Y#, Dong Q#, Fang J, Chen A, Lan Z, Ye Y, Yan J*, Liang Q*. Wogonin inhibits oxidative stress and vascular calcification via modulation of heme oxygenase-1. Eur J Pharmacol. 958(2023);176070.
3. Chen A#, Lan Z#, Li L#, Xie L, Liu X, Yang X, Wang S, Liang Q, Dong Q, Feng L, Li Y, Ye Y, Fu M, Lu L*, Yan J*. SGLT2 inhibitor canagliflozin alleviates vascular calcification through suppression of NLRP3 inflammasome.  Cardiovasc Res. 2023; Online ahead of print.
4. Ye Y#, Chen A#, Li L#, Liang Q, Wang S, Dong Q, Fu M, Lan Z, Li Y, Liu X, Ou JS, Lu L*, Yan J*. Repression of the antiporter SLC7A11/Glutathione/Glutathione Peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification. Kidney Int. 2022;102(6):1259-1275. 
5. Lan Z#, Chen A#, Li L#, Ye Y, Liang Q, Dong Q, Wang S, Fu M, Li Y, Liu X, Zhu Z, Ou JS, Qiu X, Lu L*, Yan J*. Downregulation of HDAC9 by the ketone metabolite β-hydroxybutyrate suppresses vascular calcification. J Pathol. 2022;258(3):213-226. 
6. Wang S#, Li L#, Liang Q#, Ye Y, Lan Z, Dong Q, Chen A, Fu M, Li Y, Liu X, Ou JS, Lu L*, Yan J*. Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair. J Mol Cell Cardiol. 2022;173:154-168
7. Liu X#, Chen A#, Liang Q#, Yang X, Dong Q, Fu M, Wang S, Li Y, Ye Y, Lan Z, Chen Y, Ou JS, Yang P, Lu L*, Yan J*. Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway. Aging Cell. 2021;20(6):e13377.
8. Yang X#, Chen A#, Liang Q#, Dong Q, Fu M, Liu X, Wang S, Li Y, Ye Y, Lan Z, Ou JS, Lu L*, Yan J*. Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease. Free Radic Biol Med. 2021:S0891-5849(21)00385-3.
9. Dong Q#, Chen Y#, Liu W, Liu X, Chen A, Yang X, Li Y, Wang S, Fu M, Ou JS, Lu L*, Yan J*. 25-Hydroxycholesterol promotes vascular calcification via activation of endoplasmic reticulum stress. Eur J Pharmacol. 2020. doi.org/10.1016/j.ejphar.2020.173165.
10. Kong Y#, Liang Q#, Chen Y#, Yang P, Liu X, Li Y, Feng S, Wu J, Liu W, Tang J, Yu H, Ou JS, Lu L*, Yan J*. Hyaluronan negatively regulates vascular calcification involving BMP2 signaling. Lab Invest. 2018;98(10): 1320-1332.
11. Song Y, Hou M, Li Z, Luo C, Ou JS, Yu H, Yan J, Lu L* .  TLR4/NF-κB/Ceramide signaling contributes to Ox-LDL-induced calcification of human vascular smooth muscle cells. Eur J Pharmacol. 2017; 794:45-51.
12. Hou M, Song Y, Li Z, Luo C, Ou JS, Yu H, Yan J, Lu L*. Curcumin attenuates osteogenic differentiation and calcification of rat vascular smooth muscle cells. Mol Cell Biochem. 2016; 420(1-2): 151-60.   
13. Liao L#, Zhou Q#, Song Y, Wu W, Yu H, Wang S, Chen Y, Ye M, Lu L*. Ceramide mediates Ox-LDL-induced human vascular smooth muscle cell calcification via p38 mitogen-activated protein kinase signaling. PLoS One. 2013 Dec 16;8(12):e82379 
14.  Lu L, Wu W*, Yan J, Li X, Yu H, Yu X. Adriamycin-induced Autophagic Cardiomyocyte Death Plays a Pathogenic Role in a Rat Model of Heart Failure. Int J Cardiol. 2009;134(1):82-90.

Textbook monograph

1. Editorial Board of Applied Hypertension (4th Edition). Science Press, 2023/06,
2. Associate Editor
National higher education five-year clinical medicine summary of pathophysiology.
China Medical Science and Technology Press, 2018/12
3. Editor of the national higher education five-year clinical medicine simultaneous exercise collection of pathophysiology. China Medical Science and Technology Press, 2019/4/20
4. Translation of medical teachers must read - practical teaching guidance. Peking University Medical Press, 2019/01
5. Editorial board of pathophysiology test site. Science and Technology Academic Press, 2007/04

Award honor

2023/07: First Prize of the 11th University-level Undergraduate Teaching Achievement Award of Sun Yat-sen University
2022/12:22 Outstanding Young and Middle-aged Teachers Award of Clinical Medicine Professional by Kelin Medical Education Foundation Excellent Clinical Teaching Teacher
2022/09: Excellent Teaching Quality Engineering Award of Sun Yat-sen Medical College in 2021
2022/09: Excellent Reviewer of Journal of Sun Yat-sen University (Medical Science Edition) in 2021
2012/01: Excellent Head Teacher of Sun Yat-sen University
2016/10: The third prize of the sixth National Basic Teaching Skills Competition for Young Teachers in Medical Colleges and Universities
2014/12: First prize in the 2014 Young Teachers Teaching Competition of Sun Yat-sen University