Subject Major:
Biochemistry and Molecular Biology (first-level discipline: Biology); Molecular Medicine (Level 1 Discipline: Basic Medicine)

Personal profile

Gao Guoquan, second-level professor, doctoral supervisor, Yixian Outstanding Scholar of Sun Yat-sen University. Graduated from Bengbu Medical College in 1986 with a bachelor's degree in Medicine. In 1992, he graduated from Sun Yat-sen University of Medical Sciences with a master's degree in medical biochemistry. In 1997, he graduated from Sun Yat-sen University of Medical Sciences with a Doctor degree in Medical biochemistry. From 1999.1 to 2002.5, he worked as a postdoctoral researcher at the Department of Biochemistry, Medical College of Georgia and the South Carolina Eye Institute. Former Vice president of Sun Yat-sen Medical College, now editor-in-chief of the Journal of Sun Yat-sen University (Medical Science Edition), Deputy director of the Precision Medicine Center of Sun Yat-sen University, director of the National Experimental Teaching Demonstration Center of Basic Medicine of Sun Yat-sen University, chairman of the Guangdong Biochemistry and Molecular Biology Society, chairman of the Department of Basic Medicine and the Department of Biochemistry and Molecular Biology of Sun Yat-sen Medical College. Selected as the first New century outstanding talents of the Ministry of Education, the leading talents of the Guangdong Special Support Plan, the national training object of the thousand and ten projects of colleges and universities in Guangdong Province, and enjoy the government subsidy of The State Council.
Long-term research work on diabetes, tumor metabolism, pathological angiogenesis. He has chaired the National Natural Science Foundation of China, the Major New Drug Project of the Ministry of Science and Technology, the National Key Research and Development Plan and the Guangzhou Project of Guangdong Province, and has published 109 SCI indexed papers (nearly 70 corresponding authors) in international professional journals such as PNAS, STTT, Diabetes, Diabetologia and J Biol Chem. He was cited more than 3000 times, h-Index 36 (cited in Scopus, ID7403171158). His research achievements won the second Prize of Natural Science of Universities (Ministry of Education) and Guangdong Province Excellent Scientific Research Achievements (2009), and won the first prize of Jiangsu Province Science and Technology Progress as the third person (2018). Granted 4 invention patents. He is the director of Guangdong Provincial Engineering Research Center for Gene Manipulation and Biomacromolecular Products, and the director of Guangdong Provincial University Key Laboratory of Marine Microbial Functional Molecules.
He has been teaching undergraduate and postgraduate courses in medical biochemistry for a long time and has carried out teaching and research work. He is the chief editor of Biochemistry and Molecular Biology, a series of national planning textbooks for graduate students, clinical medicine and nursing undergraduate students of the People's Medical Publishing House, and the chief editor of Medical Molecular and Cellular Genetic Basis, a core textbook for basic medicine 101 Plan of the Ministry of Education. He is currently the executive director of the Chinese Society of Biochemistry and Molecular Biology and the chairman of the Education Branch. Deputy leader of Basic Medicine Group of the Joint Conference of National Experimental Teaching Demonstration Center of Higher Education, the first chairman of Medical Research and Education Publishing Alliance of higher education, and the first chairman of Medical Journal Alliance of Sun Yat-sen University. He used to be the vice president in charge of graduate and undergraduate education of Sun Yat-sen Medical College, and he is one of the main founders of the basic medicine specialty of Sun Yat-sen Medical College, and one of the main architects of the \"disease-oriented, clinical integration, innovation-leading\" basic medical graduate training system. As the first or main completed adult, he has won 1 second prize of national teaching Achievement Award, 3 first prize and second prize of Teaching Achievement of Guangdong Province, and 1 second prize of teaching achievement of Medical Science Working Committee of Chinese Society of Academic Degree and Graduate Education. Selected as Baosteel excellent teachers, Guangdong Province higher education teachers and Sun Yat-sen University famous teachers.

Teaching and academic positions

Associate Dean of Undergraduate and Graduate Education, Sun Yat-sen Medical College (2013-2021)
Editor-in-chief, Journal of Sun Yat-sen University (Medical Sciences Edition)
Chairman of Education Branch of Chinese Society of Biochemistry and Molecular Biology
Deputy Director, Precision Medicine Research Center, Sun Yat-sen University
Director of Medical supervision Group of graduate education, Sun Yat-sen University
Director, Department of Basic Medicine, Zhongshan Medical College, Sun Yat-sen University
Director, Department of Biochemistry and Molecular Biology, Sun Yat-sen University
Member of the Expert Committee on the development of basic medical questions of the National Doctor Qualification Examination
China Education, Science, Culture, Health and Sports Union Young Teachers Teaching Competition Medical Team Leader (5th session)
Member of the Guiding Committee of Clinical Medicine Teaching in Guangdong University
Chairman of Guangdong Biochemistry and Molecular Biology Society
Director, Engineering Technology Research Center for Gene Manipulation and biomacromolecular Products, Guangdong Province
Deputy leader of basic Medicine group of National Experimental Teaching Demonstration Center Joint Conference
He was the first president of the Medical Research and Educational Publishing Alliance of Higher Education
First president of Sun Yat-sen University Medical Journal Alliance
Director of national Experimental Teaching Demonstration Center of Basic Medicine, Sun Yat-sen University

Scientific research achievement

The role and molecular mechanism of human plasminogen K5 and its mutants in the treatment of vasoproliferative diseases. The second prize of Natural Science Award for Outstanding Achievement in Scientific Research of Universities (2009), the first completed person
The role and molecular mechanism of human plasminogen K5 and its mutants in the treatment of vasoproliferative diseases. Second Prize of Science, Technology and Natural Science of Guangdong Province (2009), the first completed person
Antitumor effect of extracellular matrix degradation products, protein engineering and its application. The first prize of Jiangsu Science and Technology Award (2018), the third finisher.
Authorized invention patent
Mutant human plasminogen Kringle 5 and its preparation method and application (Patent No. ZL 201010600078.9; Notice of Authorization dated July 4, 2012). First consummated person
An anti-PEDF monoclonal antibody and its preparation method and application (Patent No. ZL201210245123.2, License date: June 25, 2014). First consummated person
Application of anti-PEDF monoclonal antibody in erectile dysfunction disease in diabetic men (Patent No. ZL201610359837.4, License Announcement Date November 12, 2019). First consummated person
Application of MATE1 gene in the treatment of colorectal cancer (Authorization announcement number: CN110760581B, Authorization announcement date: November 19, 2021). First consummated person

Teaching achievement

• Sun Yat-sen University's first postgraduate education and teaching achievement Special prize (2023). The construction and effect of graduate molecular medicine specialty. Gao Guoquan, Yang Xia, QI Weiwei, CAI Weibin, LI Bo, SONG Erwei, Li Jun, ZHOU Jiaguo, SONG Zhihong, YUAN Jie.
• Higher education (postgraduate) National teaching achievement Second prize (2023). Construction and practice of "disease-oriented, clinical integration, Innovation-leading" medical graduate training system. Song Erwei, GAO Guoquan, LI Chunhai, Lin Tianxin, Kuang Ming, LAN Ping, WANG Shuzhen, GUO Kaihua, Song Bin, Yang Xia, Chen Suijun, ZHOU Jiaguo, Shen Jun, QI Weiwei, QI Fangfang.
• The second prize of the first National Excellent Teaching Materials of the Ministry of Education (2021). Biochemistry and Molecular Biology (Associate editor, 9th edition, 2018, People's Medical Publishing House, for undergraduate Clinical Medicine)
• The first National Excellent Teaching Materials Group Award of the Ministry of Education (2021). Sun Yat-sen College of Medicine, Sun Yat-sen University (Principal member)
• Second Prize of Higher Education Teaching Achievement in Guangdong Province (2021). To build a basic medical graduate training system of "disease-oriented, clinical integration, and innovation-leading". Gao Guoquan, Song Erwei, Kuang Ming, LAN Ping, Guo Kaihua, Yang Xia, Zhou Jiaguo, Zhu Jinghuan, Qu Huaigang, Qi Weiwei.
• First Prize in Teaching Achievement of Sun Yat-sen University (2021). To build a basic medical graduate training system of "disease-oriented, clinical integration, and innovation-leading". Gao Guoquan, Song Erwei, Kuang Ming, LAN Ping, Guo Kaihua, Yang Xia, Zhou Jiaguo, Zhu Jinghuan, Qu Huaigang, Qi Weiwei.
• First Prize in Teaching Achievement of Sun Yat-sen University (2021). Exploration of integrated experimental teaching mode of "double classroom" in basic medicine based on innovation and practical ability training. Wu Minhao, Gao Guoquan, Wang Xuelan, Zhou Ti, Peng Yi, Liu Chao, Yan Huijun, Xu Zhiwei.
• Second Prize of Higher Education Teaching Achievement in Guangdong Province (2019). The establishment and practice of graduate training system based on group guidance and rotation system. Gao Guoquan, Guan Yongyuan, Yang Tianxin, Yang Xia, Wang Weidong, Zhou Jiaguo, Au Jingsong, Tan Hongmei, Li Chunling, Zhou Ti.
• First Prize in Teaching Achievement of Sun Yat-sen University (2019). The establishment and practice of graduate training system based on group guidance and rotation system. Gao Guoquan, Guan Yongyuan, Yang Tianxin, Yang Xia, Wang Weidong, Zhou Jiaguo, Au Jingsong, Tan Hongmei, Li Chunling, Zhou Ti.
• The second prize of Medical and Pharmaceutical Graduate Education Achievement Award (2017). The establishment and practice of group (cardiovascular) guidance and rotation system for graduate training. Gao Guoquan, Guan Yongyuan, Yang Tianxin, Yang Xia, Wang Weidong. Awarding institution: Medical Department Working Committee of Chinese Society of Academic Degree and Graduate Education
• Guangdong Province Higher Education teaching achievement first prize (2010). The exploration and practice of using information technology to promote the training of medical innovative talents. Song Zhihong, Guo Yibin, Gao Guoquan, Tao Yan, Tao Sha.

Over the past ten years, he has presided over scientific research projects

• 2021-2024 Construction of high quality journal of Sun Yat-sen University (Medical Science Edition), 1 million yuan, the first applicant
• 2021-2024 Guangzhou Key Laboratory of Metabolic Diseases, 500,000 yuan
• The Key role and mechanism of PEDF in regulating ATGL degradation and lipolysis activity of adipocytes and exacerbating obesity from 2021 to 2024
• National Natural Science Foundation, 550,000 yuan, the first applicant
• Key Molecules regulating ATGL degradation and lipolysis activity of adipocytes and Their Role in Obesity from 2020 to 2022, Key Project of Guangdong
• Regional Joint Fund, 1 million yuan, First applicant
• Effect and mechanism of metformin in selective treatment of KRAS mutant colorectal cancer from 2020 to 2022
• Guangzhou Basic Research Program People's Livelihood Science and Technology, 1 million yuan, the first applicant
• 2020.1-2020.12 Project of Scientific and Technological Achievements Transformation, Sun Yat-sen University, Preclinical research on novel genetic engineering drug candidate K5-M5 for the treatment of vascular neoplastic diseases, 300,000, the first applicant
• 2019-2022 Identification and mechanism study of Key secretory Factors regulating tissue homeostasis and metabolic Balance, National Key Research and Development Program of the Ministry of Science and Technology (2018YFA0800400), backbone project, allocation of 700,000 yuan
• 2019-2022 Role and mechanism of PEDF in inhibiting heterogeneous angiogenesis in breast Cancer (81872165), National Natural Science Foundation of China, direct funding 570,000 yuan, the first applicant
• 2018 Sun Yat-sen University 2018 International Research Cooperation Research Key project, KBP regulation of macrophage polarization and fibroblast activation to promote the development of diabetic foot key role and its inhibitor research and development, 100,000 yuan, the first applicant
• 2018 Sun Yat-sen University 2018 Annual Research Platform Operation funding project, Guangdong Gene Manipulation and Biological macromolecular
• Products Engineering Technology Research Center, 100,000 yuan, the first applicant
• 2017-2018    Milstein Medical Asian American Partnership Foundation Research Project Award in Translational Medicine 
              Project Title:              The preclinical research of monoclonal antibody drug treatment for diabetic foot targeting the blood vessels. 
              Grant Duration:         One year with non-cost extension of an additional year allowable. 
• Grant Amount: Total amount: $60,000; $50,000 to Zhongshan School of Medicine, Sun Yat-sen University and $10,000 to University of Oklahoma Health Sciences Center.
• 2017-2018 Research on Key pathogenic molecules and Mechanisms of diabetic microvascular Complications, "National Key Research and Development Plan Prospective Cultivation Project", Sun Yat-sen University, 500,000 yuan, the first applicant
• 2014-2017 The Key Role and Mechanism of PEDF in diabetic wound Healing (2015A030311043), the Key project of Natural Science Foundation of Guangdong Province, 300,000 yuan, the first applicant
• 2015-2017 Monoclonal antibody candidate drug targeting angiogenesis for the treatment of diabetic foot (201508020033), Guangzhou Science and Technology Plan Industry-university-research Collaborative Innovation major project (Livelihood Science and Technology Research), 1 million yuan, the first applicant
• 2015-2018 The role and mechanism of PEDF regulating endothelial progenitor cells in inhibiting diabetic wound healing (81471033), National Natural Science Foundation of China, 750,000 yuan, First applicationpeople
• 2013-2015 Preclinical research on a new genetic engineering drug candidate targeted by angiogenesis for the treatment of liver cancer (2013ZX0902-053), the 12th Five-Year major special project for New Drug Development of the Ministry of Science and Technology, 3.91 million yuan, the first applicant
• 2013-2016 Role and mechanism of PEDF in inhibiting Nasopharyngeal carcinoma metastasis by regulating nasopharyngeal carcinoma cell EMT (81272338), National Natural Science Foundation of China, 650,000 yuan, First Applicant
• 2012-2015 The role and mechanism of PEDF in the repair of peripheral microvascular injury in diabetes Mellitus, Guangdong Provincial High Level Talents Project, 500,000 yuan, the first applicant
• 2012-2015 The dual effect and mechanism of PEDF34 on inhibiting angiogenesis and inducing apoptosis in prostate cancer (81172163), National Natural Science Foundation of China, 600,000 yuan, the first applicant

Academic works and textbooks

Published corresponding author papers in the last 10 years (* Co-corresponding author, # Co-first author) :

1. Zhenzhen Fang #, Gang Shen #, Yina Wang #, Fuyan Hong #, Xiumei Tang, Yongcheng Zeng, Ting Zhang, Huanyi Liu, Yanmei Li, Jinhong Wang, Jing Zhang, Anton Gao, Weiwei Qi, Xia Yang*, Ti Zhou*, Guoquan Gao*. Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease. Signal Transduct Target Ther. 2024 Mar 12;9(1):66. doi: 10.1038/s41392-024-01781-9.
2. Yanlan Long#, Zhen Zhao#, Wanting Xie#, Jinhui Shi#, Fengyu Yang, Dan Zhu, Ping Jiang, Qilong Tang, Zhou Ti, Bin Jiang*, Xia Yang*, Guoquan Gao*, Weiwei Qi*. Kallistatin leads to cognition impairment via downregulating glutamine synthetase. Pharmacol Res. 2024 Apr:202:107145. doi: 10.1016/j.phrs.2024.107145.
3. Pu M, Zhang J, Hong F, Wang Y, Zhang C, Zeng Y, Fang Z, Qi W, Yang X*, Gao G*, Zhou T*. The pathogenic role of succinate-SUCNR1: a critical function that induces renal fibrosis via M2 macrophage. Cell Commun Signal. 2024 Jan 30;22(1):78. doi: 10.1186/s12964-024-01481-5. PMID: 38291510
4. Zhang X, Yang F, Huang Z, Liu X, Xia G, Huang J, Yang Y, Li J, Huang J, Liu Y, Zhou T, Qi W, Gao G*, Yang X*. Macrophages Promote Subtype Conversion and Endocrine Resistance in Breast Cancer. Cancers (Basel). 2024 Feb 5;16(3):678. doi: 10.3390/cancers16030678.
5. Wei Xiang, Longhui Li, Qin Zhao, Yongcheng Zeng, Jinhui Shi, Zitong Chen, Guoquan Gao*, Kunbei Lai*. PEDF protects retinal pigment epithelium from ferroptosis and ameliorates dry AMD like pathology in a murine model. GeroScience, 2024 Apr;46(2):2697-2714. doi: 10.1007/s11357-023-01038-3. Epub 2023 Dec 28.
6. Weiwei Qi#, Zhenzhen Fang#, Chuanghua Luo#, Honghai Hong#, Yanlan Long, Zhiyu Dai, Junxi Liu, Yongcheng Zeng, Ti Zhou, Yong Xia*, Xia Yang*, Guoquan Gao*. The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase. J Mol Cell Biol. 2024 Apr 4;15(10):mjad064. doi: 10.1093/jmcb/mjad064.
7. Weiwei Qi#, Dan Zhu#, Ping Yin#, Xiaoqiong Gu, Zhen Zhao, Miaoxin Li, Chang Dong, Qilong Tang, Wanting Xie, Ti Zhou, Huimin Xia, Xiu Qiu*, Xia Yang*, Guoquan Gao*. Pigment epithelium-derived factor (PEDF), a novel adipokine contributes to gestational diabetes mellitus (GDM). J Clin Endocrinol Metab. 2023 Dec 21;109(1):e356-e369. doi: 10.1210/clinem/dgad413.
8. Tianxiao Gao #, Jieye Huang #, Haofan Yin #, Jiajia Huang #, Jinye Xie, Ti Zhou, Wei Fan, Xia Yang, Guoquan Gao*, Zhiming Li*. Inhibition of extranodal NK/T-cell lymphoma by Chiauranib through an AIF-dependent pathway and its synergy with L-asparaginase. Cell Death Dis. 2023 May 9;14(5):316. doi: 10.1038/s41419-023-05833-w.
9. Wei Xiang#, Longhui Li#, Fuyan Hong, Yongcheng Zeng, Jin Zhang, Jinye Xie, Gang Shen, Jinhong Wang, Zhenzhen Fang, Weiwei Qi, Xia Yang, Guoquan Gao*, Ti Zhou*. N-cadherin cleavage: A critical function that induces diabetic retinopathy fibrosis via regulation of β-catenin translocation. FASEB J. 2023 Apr;37(4):e22878. doi: 10.1096/fj.202201664RR.
10. Min Pu, Jing Zhang, Yongcheng Zeng, Fuyan Hong, Weiwei Qi, Xia Yang, Guoquan Gao*, Ti Zhou*. Succinate-SUCNR1 induces renal tubular cell apoptosis. Am J Physiol Cell Physiol. 2023 Feb 1;324(2):C467-C476. doi: 10.1152/ajpcell.00327.2022.
11. Haofan Yin#, Tianxiao Gao#, Jinye Xie, Zhijian Huang, Xiaoyan Zhang, Fengyu Yang, Weiwei Qi, Zhonghan Yang, Ti Zhou*, Guoquan Gao*, Xia Yang*. FUBP1 promotes colorectal cancer stemness and metastasis via DVL1‐mediated activation of Wnt/β‐catenin signaling. Mol Oncol. 2021 Dec;15(12):3490-3512. doi: 10.1002/1878-0261.13064.
12. Luo C, Yin H, Gao T, Ma C, Liu J, Zhang T, Xu Z, Wang X, Zhang D, Qi W, Yang Z, Gao G, Yang X, Zhou T. PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor. Cell Death Dis. 2021 Mar 17;12(4):295. doi: 10.1038/s41419-021-03583-1.
13. Liu J, Qian B, Zhou L, Shen G, Tan Y, Liu S, Zhao Z, Shi J, Qi W, Zhou T, Yang X, Gao G, Yang Z. IL25 Enhanced Colitis-Associated Tumorigenesis in Mice by Upregulating Transcription Factor GLI1. Front Immunol. 2022 Mar 14:13:837262. doi: 10.3389/fimmu.2022.837262. eCollection 2022
14. Shen G, Li Y, Hong F, Zhang J, Fang Z, Xiang W, Qi W, Yang X, Gao G, Zhou T. A role for Snail-MnSOD axis in regulating epithelial-to-mesenchymal transition markers expression in RPE cells. Biochem Biophys Res Commun. 2021 Dec 31:585:146-154. doi: 10.1016/j.bbrc.2021.11.039.
15. Di Che#, Zhenzhen Fang#, Li Yan, Jieping Du, Fangping Li, Jinye Xie, Juan Feng, Ping Yin, Weiwei Qi, Zhonghan Yang, Jianxing Ma, Xia Yang, Guoquan Gao*, Ti Zhou*.Elevated pigment epithelium-derived factor induces diabetic erectile dysfunction via interruption of the Akt/Hsp90β/eNOS complex. Diabetologia. 2020 Sep;63(9):1857-1871. doi: 10.1007/s00125-020-05147-y.
16. Jinye Xie#, Liangping Xia#, Wei Xiang, Wenzhuo He, Haofan Yin, Fang Wang, TianxiaoGao,Weiwei Qi, Zhonghan Yang, Xia Yang*, Ti Zhou*, Guoquan Gao*. Metformin selectively inhibits metastatic colorectal cancer with the KRAS mutation by intracellular accumulation through silencing MATE1. PNAS June 9, 2020 117 (23) 13012-13022.
17. Ping Jiang#, Mao Huang#, Weiwei Qi#, Fenghua Wang, Tianyou Yang, Tianxiao Gao, Chuanghua Luo, Jing Deng, Zhonghan Yang, Ti Zhou, Yan Zou, Guoquan Gao*, Xia Yang*. FUBP1 promotes neuroblastoma proliferation via enhancing glycolysis-a new possible marker of malignancy for neuroblastoma. Journal of Experimental & Clinical Cancer Research. 2019 Sep 11; 38(1):400. doi: 10.1186/s13046-019-1414-6. 
18. Cen Li#, Zhijian Huang#, LiuqingZhu#, Xianhuan Yu, Tianxiao Gao, Juan Feng, Honghai Hong, Haofan Yin, Ti Zhou, Weiwei Qi, Zhonghan Yang, Chao Liu*, Xia Yang*, Guoquan Gao*. The contrary intracellular and extracellular functions of PEDF in HCC development. Cell Death & Disease. 2019 Oct 3;10(10):742. doi: 10.1038/s41419-019-1976-4. 
19. Yuling Mao#, Liuqing Zhu#, Zhijian Huang#, Chuanghua Luo, Ti Zhou, Lei Li, Guannan Wang, Zhonghan Yang, Weiwei Qi*, Xia Yang*,Guoquan Gao*. Stem-like tumor cells involved in heterogeneous vasculogenesis in breast cancer. Endocr Relat Cancer. 2020 Jan. pii: ERC-19-0054.R1. doi: 10.1530/ERC-19-0054.
20. Jing Deng, Ping Jiang, Tianyou Yang, Mao Huang, JinyeXie, Chuanghua Luo, WeiweiQi, Ti Zhou, ZhonghanYang, Yan Zou, GuoquanGao，XiaYang.β2-adrenergic receptor signaling promotes neuroblastoma cell proliferation via activating autophagy. Oncology Reports. 2019 Aug 6. doi: 10.3892/or.2019.7266. 
21. Jing Deng, Ping Jiang, Tianyou Yang, Mao Huang, WeiweiQi, Ti Zhou, ZhonghanYang, Yan Zou, GuoquanGao, XiaYang.Targeting β3-adrenergic receptor signaling inhibits neuroblastoma cell growth via suppressing the mTOR pathway. Biochemical and Biophysical Research Communications. 2019 Jun 18;514(1):295-300. doi: 10.1016/j.bbrc.2019.04.099. 
22. Feng J#, Dong C#, Long Y, Mai L, Ren M, Li L, Zhou T, Yang Z, Ma J, Yan L*, Yang X*, Gao G*, Qi W*. Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization. Cell Commun Signal. 2019 Jun 10; 17(1):60. doi: 10.1186/s12964-019-0376-9.
23. Ma L, Luo S, Zhou L, Zhao Z, Li Q, Xu L, Gong B, Qi W, Zhou T, Yang X, Gao G*, Mei W*, Yang Z*. TanshinoneⅡAphenanthroimidazole derivative polarizes macrophage to improve metabolic homeostasis. Biochemical and Biophysical Research Communications. 2019 Jun 30;514(3):861-867. doi:10.1016/j.bbrc.2019.05.056. Epub 2019 May 10. 
24. Ma C, Xie J, Luo C, Yin H, Li R, Wang X, Xiong W, Zhang T, Jiang P, Qi W, Zhou T, Yang Z, Wang W, Ma J, Gao G*, Yang X*. OxLDL promotes lymphangiogenesis and lymphatic metastasis in gastric cancer by upregulating VEGF C expression and secretion. Int J Oncol. 2019 Feb;54(2):572-584. doi: 10.3892/ijo.2018.4648. Epub 2018 Nov 26. 
25. Mao Huang, Weiwei Qi, Shuhuan Fang, Ping Jiang, Cong Yang, Yousheng Mo, Chang Dong, Yan Li, Jun Zhong, Weibin Cai, Zhonghan Yang, Ti Zhou, Qi Wang*, Xia Yang*, Guoquan Gao*. Pigment epithelium-derived factor plays a crucial role in the Alzheimer's disease by negative regulation of Aβ42. Neurotherapeutics, 2018 Jul;15(3):728-741. doi: 10.1007/s13311-018-0628-1.
26. Liuqing Zhu, JinyeXie, Zhenyin Liu, Zhijian Huang, Mao Huang, Haofan Yin, Weiwei Qi, Zhonghan Yang, Ti Zhou, Guoquan Gao*, Jing Zhang*, Xia Yang*. PEDF/VEGF ratio plays a crucial role in the spontaneous regression of infant hemangioma and the therapeutic effect of propranolol. Cancer Science, 2018. DOI:10.1111/cas.13611.
27. Ma C, Luo C, Yin H, Zhang Y, Xiong W, Zhang T, Gao T, Wang X, Che D, Fang Z, Li L, Xie J, Huang M, Zhu L, Jiang P, Qi W, Zhou T, Yang Z, Wang W, Ma J, Gao G*, Yang X*. Kallistatin inhibits lymphangiogenesis and lymphatic metastasis of gastric cancer by downregulating VEGF-C expression and secretion. Gastric Cancer. 2017 Dec 14. doi: 10.1007/s10120-017-0787-5.
28. Fang S, Hong H, Li L, He D, Xu Z, Zuo S, Han J, Wu Q, Dai Z, Cai W, Ma J, Shao C, Gao G*, Yang X*. Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1α and GRP78. Cell Death Dis.2017 Oct 26;8(10):e3144. doi: 10.1038/cddis.2017.528. 
29. Zhang T, Yin P, Zhang Z, Xu B, Che D, Dai Z, Dong C, Jiang P, Hong H, Yang Z, Zhou T, Shao J, Xu Z, Yang X*, Gao G*. Deficiency of pigment epithelium-derived factor in nasopharyngeal carcinoma cells triggers the epithelial-mesenchymal transition and metastasis. Cell Death Dis. 2017 Jun 1;8(6):e2838. doi:10.1038/cddis.
30. Ma C, Yin H, Zhong J, Zhang Y, Luo C, Che D, Fang Z, Li L, Qin S, Liang J, Qi W, Yang Z, Zhou T, Ma J, Yang X*, Gao G*. Kallistatin exerts anti-lymphangiogenic effects by inhibiting lymphatic endothelial cell proliferation, migration and tube formation. Int J Oncol. 2017 Apr 20. doi: 10.3892/ijo.2017.3972. [Epub ahead of print] PubMed PMID: 28440474.
31. Feng J, Li L, Ou Z, Li Q, Gong B, Zhao Z, Qi W, Zhou T, Zhong J, Cai W, Yang X, Zhao A, Gao G*, Yang Z*. IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity. Cell Mol Immunol. 2018 May;15(5):493-505. doi: 10.1038/cmi.2016.71. Epub 2017 Feb 13. PubMed PMID: 28194019.
32. Zhou T, Che D, Lan Y, Fang Z, Xie J, Gong H, Li C, Feng J, Hong H, Qi W, Ma C, Yang Z, Cai W, Zhong J, Ma J, Yang X*, Gao G*. Mesenchymal marker expression is elevated in Müller cells exposed to high glucose and in animal models of diabetic retinopathy. Oncotarget. 2017 Jan 17;8(3):4582-4594. doi:10.18632/oncotarget.13945. PubMed PMID: 27999189.
33. Che D, Zhou T, Lan Y, Xie J, Gong H, Li C, Feng J, Hong H, Qi W, Ma C, Wu Q, Yang X*, Gao G*. High glucose-induced epithelial-mesenchymal transition contributes to the upregulation of fibrogenic factors in retinal pigment epithelial cells. Int J Mol Med. 2016 Dec;38(6):1815-1822. doi: 10.3892/ijmm.2016.2768. PubMed PMID: 27748912.
34. Li S, Mao Y, Zhou T, Luo C, Xie J, Qi W, Yang Z, Ma J, Gao G*, Yang X*. Manganese superoxide dismutase mediates anoikis resistance and tumor metastasis in nasopharyngeal carcinoma. Oncotarget. 2016 May 31;7(22):32408-20. doi:10.18632/oncotarget.8717. PubMed PMID: 27083052; PubMed Central PMCID:PMC5078022. 
35. Liang ZW, Wang Z, Chen H, Li C, Zhou T, Yang Z, Yang X, Yang Y, Gao G*, Cai W*. Nestin-mediated cytoskeletal remodeling in endothelial cells: novel mechanistic insight into VEGF-induced cell migration in angiogenesis. Am J Physiol Cell Physiol.2015 Mar 1;308(5):C349-58. doi: 10.1152/ajpcell.00121.2014. PubMed PMID:25500739. 
36. Qi W, Yang C, Dai Z, Che D, Feng J, Mao Y, Cheng R, Wang Z, He X, Zhou T, Gu X, Yan L*, Yang X*, Ma JX*, Gao G*. High Levels of Pigment Epithelium-derived Factor in Diabetes Impair Wound Healing through Suppression of Wnt Signaling. Diabetes. 2014 Nov 3. pii: DB_141111. 
37. Li L, Yao YC, Gu XQ, Che D, Ma CQ, Dai ZY, Li C, Zhou T, Cai WB, Yang ZH, Yang X*, Gao GQ*. Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. J Biol Chem. 2014 Oct 8. pii: jbc.M114.567792.
38. Hong H, Zhou T, Fang S, Jia M, Xu Z, Dai Z, Li C, Li S, Li L, Zhang T, Qi W, Bardeesi AS, Yang Z, Cai W, Yang X*, Gao G*. Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin. Breast Cancer Res Treat. 2014 Nov; 148(1):61-72. doi: 10.1007/s10549-014-3154-9. Epub 2014 Oct 5. 
39. Huang L, Zhang T, Li S, Duan J, Ye F, Li H, She Z, Gao G*, Yang X*. Anthraquinone G503 Induces Apoptosis in Gastric Cancer Cells through the Mitochondrial Pathway. PLoS One. 2014 Sep 30; 9(9):e108286. doi: 10.1371/journal.pone.0108286. eCollection 2014.
40. Gong Q, Qiu S, Li S, Ma Y, Chen M, Yao Y, Che D, Feng J, Cai W, Ma J, Yang X, Gao G*, Yang Z*. Proapoptotic PEDF functional peptides inhibit prostate tumor growth-A mechanistic study. BiochemPharmacol. 2014 Sep 28. pii: S0006-2952(14)00556-5. doi: 10.1016/j.bcp.2014.09.012. 
41. Li L, Yao YC, Fang SH, Ma CQ, Cen Y, Xu ZM, Dai ZY, Li C, Li S, Zhang T, Hong HH, Qi WW, Zhou T, Li CY, Yang X*, Gao GQ*. Pigment Epithelial-derived Factor (PEDF)-triggered Lung Cancer Cell Apoptosis Relies on p53 Protein-driven Fas Ligand (Fas-L) Up-regulation and Fas Protein Cell Surface Translocation. J Biol Chem. 2014 Oct 31; 289(44):30785-99. doi: 10.1074/jbc.M114.590000. Epub 2014 Sep 15. 38.

Textbook monograph

Editor IN CHIEF:
Molecular and Cellular Genetic Basis of Medicine (1st edition, 2024) (National Education Ministry 101 Top Talent
Training Materials Program, Peking University Medical Press, for Basic and clinical medicine undergraduate)
Biochemistry and Molecular Biology (10th edition, paper and digital textbooks, 2024) (National and Ministry of Health planning textbooks, People's Medical Publishing House, for undergraduate clinical medicine)
Experimental Technology of Medical Molecular Biology (3rd edition, 2019) (for postgraduate students, Planning textbook of Ministry of Health, People's Medical Publishing House)
Biochemistry (2nd Ed., 2006; Third edition, 2012; Fourth edition, 2016; 5th edition, 2022) (National and Ministry of Health Planning textbook, People's Medical Publishing House, for undergraduate nursing students)
Biochemistry Study Guide and Problem Set (1st edition, 2006; Second edition, 2012)
(National and Ministry of Health planning textbook, People's Medical Publishing House, for nursing undergraduate)
Biochemistry Test Site Memory Manual (Science and Technology Literature Press, 2007)
Biochemistry Experiment (Textbook for the Twelfth Five-Year Plan of Experimental Teaching Demonstration Center of National Medical Colleges, Huazhong University of Science and Technology Press, 2013)
Deputy Editor:
Biochemistry and Molecular Biology (4th Ed., 2018; 5th edition, 2024) (National and Ministry of Health Planning Textbook, Peking University Medical Press, for undergraduate clinical medicine)
Biochemistry and Molecular Biology (4th edition, 2023) (National and Ministry of Health planning textbook, People's Medical Publishing House, for clinical medicine master system, 5+3 use)
Biochemistry and Molecular Biology (9th edition, 2018) (National and Ministry of Health planning textbook, People's Medical Publishing House, for undergraduate clinical medicine)
Biochemistry (English textbook compilation, 2018) (Science Press)
Medical Biochemistry and Molecular Biology (2nd edition, 2009) (Science Press, National planning textbook)