Personal Introduction
Hu Xuchu, male, from Shuangfeng, Hunan Province, was born in 1969 and is a supervisor for master's students. He holds a Bachelor's degree in Virology and Molecular Biology from Wuhan University, a Master's degree in Nutrition and Food Hygiene from the Academy of Military Medical Sciences, and a Doctor's degree in Pathogenic Biology from Sun Yat-sen University. His main research directions are functional genomics and bioinformatics of pathogenic organisms, as well as pathogenic molecular biology and immunology. Currently, his main research fields involve the functional genomics, pathogenic mechanisms, pathogenic gene and immunodiagnosis technologies, novel oral vaccines, immunoregulation of helminth infections, and anti-tumor mechanisms of important zoonotic parasites. He has presided over and participated as a key member in 3 projects of the National Natural Science Foundation of China, 1 project of the National Basic Research Program of China (973 Program), 1 project of the National High-Tech Research and Development Program of China (863 Program), 1 project of the National Science and Technology Support Program, 3 projects of the Doctoral Program Foundation of the Ministry of Education, and 6 projects at provincial and municipal levels. He has published more than 170 papers, including more than 23 papers as the first author or corresponding author, among which 12 are SCI papers. He has obtained 3 patents, won the "Second Prize of Natural Science in Higher Education Institutions" of the Ministry of Education as the first completer, and won 3 other provincial and ministerial awards as a participant.
Academic Achievements
Significant Academic Research Achievements and Contributions
Research on the functional genomics and bioinformatics of parasites. He took the lead in carrying out large-scale comparative functional genomics of adult Clonorchis sinensis and its metacercariae, as well as comparative functional genomics studies of four tapeworms, namely Taenia solium, Taenia saginata, Taenia asiatica, and Echinococcus granulosus. Using bioinformatics techniques, genes related to substance and energy metabolism, immunoregulation, and pathogenesis were identified from the obtained gene databases as vaccine and drug target genes. A complete theoretical and technical system for reverse research on gene function has been established. His representative achievement, "Establishment and Functional Study of the Gene Expression Profile of Clonorchis sinensis", won the "Second Prize of Natural Science in Higher Education Institutions" of the Ministry of Education and the "Second Prize of Chinese Medical Science and Technology".
A non-invasive rapid immunodetection technology platform based on artificially combined specific epitope antigens, immunogold rapid detection technology, and rapid ELISA has been established. Two patents have been obtained, and a variety of immunodetection kits have been developed.
A novel oral vaccine technology platform using the intestinal probiotic Bacillus subtilis as a delivery vector has been established. A fish vaccine for Clonorchis sinensis and a veterinary vaccine for Echinococcus have been developed and obtained national invention patents.
A screening and identification technology platform for screening anti-inflammatory and anti-tumor antigens of helminths has been established, and a number of parasite proteins with anti-allergic, anti-inflammatory, and anti-tumor functions have been screened.

Academic Works and Textbooks
Main SCI Papers Published in Recent Years

1. Zhang Z, Xu H, Gan W, Zeng S, Hu X*. Schistosoma japonicum calcium-binding tegumental protein SjTP22.4 immunization confers praziquantel schistosomulumicide and antifecundity effect in mice. Vaccine. 2012 Jul 20;30(34):5141-50. (Corresponding author)
2. Gan W, Zhang Z, Lv G, Xu H, Zeng S, Li Y, Wu W, Hu X*. The topological structure and function of Echinococcus granulosus lactate dehydrogenase, a tegumental transmembrane protein. Mol Biochem Parasitol. 2012 Aug;184(2):109-17. (Corresponding author)
3. Li Y, Xu H, Chen J, Gan W, Wu W, Wu W, Hu X*. Gene cloning, expression, and localization of antigen 5 in the life cycle of Echinococcus granulosus. (Corresponding author) Parasitol Res. 2012 Jun;110(6):2315-23.
4. Li W, Hu X, Zhang X, Ge Y, Zhao S, Hu Y, Ashman RB. Immunisation with the glycolytic enzyme enolase confers effective protection against Candida albicans infection in mice. (Co-first author) Vaccine. 2011 Jul 26;29(33):5526-33.
5. Li Y, Hu X, Liu X, Huang Y, Xu J, Zhao J, Wu Z, Yu X. Serological diagnosis of clonorchiasis: using a recombinant propeptide of cathepsin L proteinase from Clonorchis sinensis as a candidate antigen. Parasitol Res. Parasitol Res. 2012 Jun;110(6):2315-23.
6. Du L, Tang H, Ma Z, Xu J, Gao W, Chen J, Gan W, Zhang Z, Yu X, Zhou X, Hu X*. The protective effect of the recombinant 53-kDa protein of Trichinella spiralis on experimental colitis in mice. (Corresponding author) Dig Dis Sci. 2011 Oct;56(10):2810-7.
7. Wu W, Chen J, Zeng S, Zhang Z, Gan W, Yu X, Hu X*. Molecular cloning, expression, and characterization of cyclophilin A from Clonorchis sinensis. (Corresponding author) Parasitol Res. 2011 Aug;109(2):345-51.
8. Chen J, Xu H, Zhang Z, Zeng S, Gan W, Yu X, Hu X*. Cloning and expression of 21.1-kDa tegumental protein of Clonorchis sinensis and human antibody response to it as a trematode-nematode pan-specific serodiagnosis antigen. (Corresponding author) Parasitol Res. 2011 Jan;108(1):161-8.
9. Chen J, Hu X, He S, Wang L, Hu D, Wang X, Zheng M, Yang Y, Liang C, Xu J, Yu X. Expression and immune response analysis of Schistosoma japonicum VAL-1, a homologue of vespid venom allergens. Parasitol Res. 2010 May;106(6):1413-8.
10. Gan W, Zhao G, Xu H, Wu W, Du W, Huang J, Yu X, Hu X*. Reverse vaccinology approach identify an Echinococcus granulosus tegumental membrane protein enolase as vaccine candidate. (Corresponding author) Parasitol Res. 2010 Mar;106(4):873-82.
11. Li L, Hu X, Wu Z, Xiong S, Zhou Z, Wang X, Xu J, Lu F, Yu X. Immunogenicity of self-adjuvanticity oral vaccine candidate based on use of Bacillus subtilis spore displaying Schistosoma japonicum 26 KDa GST protein. Parasitol Res. 2009 Nov;105(6):1643-51.
12. Yanwen Li , Xuchu Hu, Jing Xu, Fengyu Hu, Changling Ma, Xinbing Yu* Molecular cloning and analysis of stage and tissue-specific expression of Cathepsin L- like protease from Clonorchis sinensis, Parasitol Res,2009 Aug;105(2):447-52
13. Hu F, Hu X, Ma C, Zhao J, Xu J, Yu X. Molecular characterization of a novel Clonorchis sinensis secretory phospholipase A(2) and investigation of its potential contribution to hepatic fibrosis. Mol Biochem Parasitol. 2009 Oct;167(2):127-34. (Co-first author)
14. Jiang Huang, Yan Huang , Xuan Wu, Wuying Du,Xinbing Yu, Xuchu Hu*. Identification, expression, characterization and immunolocalization of lactate dehydrogenase from Taenia asiatica , Parasitol Res, 2009 Jan;104(2):287-93. (Corresponding author)
15. Xuchu Hu*,Hongjuan Zhou ,Fengyu Hu, Jin Xu ,Yuli Zhao, Xinbing Yu .Recognition and characterization of TGF-β receptor interacting protein 1 (TRIP-1) containing WD40 repeats from Clonorchis sinensis by bioinformatics, cloning, and expression in Escherichia coli ，Parasitol Res, 2008,103:1151-1158 (Corresponding author)
16. Hu F, Yu X, Ma C, Zhou H, Zhou Z, Li Y, Lu F, Xu J, Wu Z, Hu X*. Clonorchis sinensis: expression, characterization, immunolocalization and serological reactivity of one excretory/secretory antigen-LPAP homologue, Exp Parasitol. 2007 Oct;117(2):157-64 (Corresponding author)
17. Zhou Z, Hu X, Huang Y, Hu H, Ma C, Chen X, Hu F, Xu J, Lu F, Wu Z, Yu X*, Molecular cloning and identification of a novel Clonorchis sinensis gene encoding a tegumental protein.Parasitol Res. 2007 Aug;101(3):737-42
18. Ma C, Hu X, Hu F, Li Y, Chen X, Zhou Z, Lu F, Xu J, Wu Z, Yu X* Molecular characterization and serodiagnosis analysis of a novel lysophospholipase from Clonorchis sinensis, Parasitol Res. 2007 2007 Jul;101(2):419-25.
19. Wu Z, Hu X, Wu D, Xu J, Chen S, Wu Z, Yu X.* Clonorchis sinensis: molecular cloning and functional expression of a novel cytosolic glutathione transferase Parasitol Res. 2007 Jan;100(2):227-32
20. Chen X, Hu X, Wu Z, Yu X, Ma C, Zhou Z Immunological cross-reactivity analysis on recombinant histamine-releasing factors from Schistosoma japonicum, Clonorchis sinensis, and Wistar rat. Parasitol Res 2007 Mar;100(4):749-54.
21. Lu G, Hu X, Peng Z, Xie H, Li Y, Wu Z, Yu X, Expression and characterization of lactate dehydrogenase from Schistosoma japonicum.Parasitol Res. 2006,99(5):593-6.

Scientific Research Projects

1. Molecular Mechanism of the Direct Activation of Stellate Cells by ESA of Clonorchis sinensis Leading to Hepatic Fibrosis: Hu Xuchu
   Principal Investigator: Hu Xuchu Participants: Funding: 300,000 yuan Year: 2008
2. Research on Feed Additive-Type Vaccines for Canine and Livestock Echinococcosis: Hu Xuchu
   Principal Investigator: Hu Xuchu Participants: Funding: 405,000 yuan Year: 2008
3. Research on the Mechanism of Cholangiocarcinoma Caused by Clonorchis sinensis Infection: Hu Xuchu
   Principal Investigator: Hu Xuchu Participants: Funding: 1,600,000 yuan Year: 2010

Awards and Honors
Research on the Rapid Immunochromatographic Detection Technology and Fluorescent Quantitative PCR Technology for Malaria, Second Prize of Military Scientific and Technological Progress (ranked 9th), 2005
Establishment of the Gene Expression Profile of Adult Clonorchis sinensis and Study on Functional Genes, Second Prize of Natural Science in Chinese Universities (ranked 1st), 2007
Establishment of the Gene Expression Profile of Adult Clonorchis sinensis and Study on Functional Genes, Third Prize of Scientific and Technological Progress in Guangdong Province (ranked 3rd), 2008分享