Personal Introduction
Hong Hai, Ph.D., is an Associate Professor and a Doctoral Supervisor at the School of Zhongshan Medicine, Sun Yat-sen University. He currently serves as the Deputy Director of the Department of Immunology at the School of Zhongshan Medicine. He graduated from Sun Yat-sen University with a Master's degree and a Doctor of Medicine degree. He conducted postdoctoral research at the MRC of the University of Oxford in the UK and Duke University in the United States. In late 2011, he was recruited by Sun Yat-sen University to return to China for work. So far, his related research work has been published as a corresponding author or first author (including co-authorship) in journals such as Aging & Immunity, Frontiers in Immunology, Journal of Immunotherapy, and Immunologic Research. He has presided over General Projects of the National Natural Science Foundation of China and scientific research projects of the Natural Science Foundation of Guangdong Province.

Academic Achievements
Our research team focuses on combining basic scientific research with clinical applications to serve clinical diseases, mainly conducting research related to the immunotherapy of lung cancer. Tumor adoptive immunotherapy based on tumor-infiltrating T lymphocytes (TILs) has good application prospects. I am committed to exploring the composition of TILs cells and screening T cell subsets that can exert a lasting anti-tumor immune effect, which is of great significance. Stem cell-like memory T cells (Tscm) have stem cell-like self-renewal ability and multi-directional differentiation potential, and can differentiate into memory T cells and effector T cells. Another outstanding feature of Tscm cells is their strong anti-tumor effect. This study fully understands the immunological characteristics of Tscm cells in TILs and how to effectively expand them, providing a theoretical basis for clinical applications.

Textbooks and Monographs

1. Yang J, Liu HC, Zhang JQ, Zou JY, Zhang X, Chen WM, Gu Y, Hong H. The effect of metformin on senescence of T lymphocytes. Immun Ageing. 2023 Dec 12;20(1):73. doi: 10.1186/s12979-023-00394-0. PMID: 38087369.
   Gu Y, Tang YY, Wan JX, Zou JY, Lu CG, Zhu HS, Sheng SY, Wang YF, Liu HC, Yang J, Hong H. Sex difference in the expression of PD-1 of non-small cell lung cancer. Front Immunol. 2022 Oct 20;13:1026214. doi: 10.3389/fimmu.2022.1026214. eCollection.
2. Gu Y, Sheng SY, Tang YY, Lu CG, Zou JY, Wang YF, Hong H. PD-1 Expression and Function of T-Cell Subsets in TILs From Human Lung Cancer. J Immunother. 2019 Oct;42(8):297-308.
   Tang YY, Sheng SY, Lu CG, Zhang YQ, Zou JY, Lei YY, Gu Y, Hong H. Effects of Glycogen Synthase Kinase3β Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer. J Immunother. 2018 Sep;41(7):319-328.
3. Si Yuan Sheng , Yong Gu , Chuan Gang Lu , Jian Yong Zou , Hai Hong , Rong Fu Wang . The distribution and function of human memory T cell subsets in lung cancer. Immunol Res. 2017 Jun;65(3):639-650.
   Si Yuan Sheng , Yong Gu, Chuan Gang Lu, Ying Ying Tang, Jian Yong Zou, Yu Qing Zhang, Rong Fu Wang, Hai Hong. The Characteristics of Naive-like T Cells in Tumor-infiltrating Lymphocytes From Human Lung Cancer. J Immunother. 2017 Jan;40(1):1-10.

4. Hong H, Gu Y, Sheng SY, Lu CG, Zou JY, Wu CY. The Distribution of Human Stem Cell-like Memory T Cell in Lung Cancer. J Immunother. 2016 ;39(6):233-40.

    

Scientific Research Projects
(1) National Natural Science Foundation of China, General Project, 32170810, Research on the Reverse Differentiation of TCF1 Regulating TILs Cells in Lung Cancer into Stem Cell-like Memory T Cells (TSCM), from January 1, 2022 to December 31, 2025, with a funding of 580,000 yuan, under research, Principal Investigator.
(2) Natural Science Foundation of Guangdong Province, General Project of the Natural Science Foundation of Guangdong Province, 2019A1515010190, Research on the Function and Mechanism of HDACi/VPA in Stably Reversing the Function of Exhausted CD8T Cells in Tumors, from October 2019 to September 2022, with a funding of 100,000 yuan, Principal Investigator.
(3) Public Welfare Research and Capacity Building Fund of Guangdong Province, 42020075, Research on TCF-1 Regulating the Reverse Differentiation of Memory T Cells into Stem Cell-like Memory T Cells in Tumor-infiltrating Lymphocytes of Lung Cancer, from January 2015 to December 2017, with a funding of 100,000 yuan, Principal Investigator.
(4) Startup Fund of the "Hundred Talents Program" of Sun Yat-sen University, 50000-3281305, Research on the Immunological Characteristics of Stem Cell-like Memory T Cells, from January 2012 to December 2013, with a funding of 350,000 yuan, Principal Investigator.
(5) National Natural Science Foundation of China, General Project, 82271377, Research on the Mechanism of OPN/SPP1 Promoting Myelin Regeneration in NMOSD by Mediating Microglial Phagocytosis of Myelin Debris through the STAT/Galectin3 Pathway, from January 1, 2023 to December 31, 2026, with a funding of 520,000 yuan, under research, Participant.
(6) National 973 Program Fund, 2014CB745200, Basic Research on the Intervention of Bladder Cancer by Synthetic Biological Devices, from January 2014 to December 2018, with a funding of 13.32 million yuan, Participant.
(7) Natural Science Foundation of Guangdong Province, S2012010008827, Exploration of the Mechanism of the Inhibitory Effect of PAK1 Gene on the Apoptosis of Esophageal Cancer Cells Mediated by the Wnt/β-catenin Signaling Pathway. From January 2012 to December 2014, with a funding of 50,000 yuan, Participant.