Personal Profile
Guo Kaihua, Professor and Master's Supervisor, works in the Department of Human Anatomy of the School of Basic Medical Sciences, Sun Yat-sen University. He obtained a Bachelor of Medicine degree in 1997 and a Master's degree in Human Anatomy and Histology and Embryology from Sun Yat-sen University in 2003. Subsequently, he has been working at the university since then. In 2010, he received a Doctor's degree in Human Anatomy and Histology and Embryology from Sun Yat-sen University.
Research Field: Pathogenesis and treatment of degenerative diseases of the central nervous system. The current main research direction is the function and mechanism of nestin protein expression in mature neurons of the basal forebrain.
He has successively presided over and participated in a number of national, provincial and ministerial scientific research projects, published several scientific research papers, and won the second prize of the Young and Middle-aged Teachers' Teaching Competition of Sun Yat-sen University twice.

Academic Achievements
Published Papers

1. Effects of Ageing and Alzheimer’s Disease on Mitochondrial Function of Human Platelets
   All Authors: Shi C, Guo K, Yew DT, Yao Z, Forster EL, Wang H, Xu J*
   Journal: Exp Gerontol, 2008, 43(6):589-94.
   Publication Year: 2008
2. Ginkgo biloba extract EGb761 protects against aging-associated mitochondrial dysfunction in platelets and hippocampi of SAMP8 mice
   All Authors: Shi C, Xiao S, Liu J, Guo K, Wu F, Yew DT, Xu J*
   Journal: Platelets, 2010, 21(5):373-379.
   Publication Year: 2010
3. The nestin-expressing and non-expressing neurons in rat basal forebrain display different electrophysiological properties and project to hippocampus
   All Authors: Zhu J, Gu H, Yao Z*, Zou J, Guo K, Li D, Gao T
   Journal: BMC Neurosci, 2011, 20(12):129-139.
   Publication Year: 2011
4. Tolerance of Nestin+ Cholinergic Immunoreactive Neurons in Basal Forebrain against Cytotoxicity of Colchicine.
   All Authors: Jing Yu, Kaihua Guo(co-first author), Dongpei Li, Jinhai Duan, Juntao Zou, Junhua Yang, Zhibin Yao*.
   Journal: Neural Regen Res, 2011,6(24):1860-1864.
   Publication Year: 2011
5. Effects of hypoxia on progranulin expression in HT22 mouse hippocampal cells
   All Authors: Luo L, Lü L, Lu Y, Zhang L, Li B, Guo K, Chen L, Wang Y, Shao Y, Xu J.
   Journal: Mol Med Rep, 2014; 9(5):1675-80.
   Publication Year: 2014
6. Chemical identification of nestin-immunoreactive neurons in the rat basal forebrain: a re-examination.
   All Authors: Guo KH, Zhu JH, Yao ZB*, Gu HY, Zou JT, Li DP.
   Journal: Neurochemistry International,2010,56(5):694-702.
   Publication Year: 2010
7. Progranulin expression in neural stem cells and their differentiated cell lineages: An immunocytochemical study
   All Authors: LANHAI LÜ,LI LUO,YINGHONG LU,LIZHI CHEN,JIE XU and KAIHUA GUO*
   Journal: Mol Med Rep, 2013,8(5):1359-136.
   Publication Year: 2013
8. Special function of nestin + neurons in the medial septum-diagonal band of Broca in adult rats
   All Authors: Zhao Y, Guo K（co-first）, Li D, Yuan Q, Yao Z
   Journal: Neural Regen Res, 2014;9(3):308-17
   Publication Year: 2014
9. Postnatal Development of Nestin Positive neurons in Rat Basal Forebrain: Different Onset and Topography with Choline Acetyltransferase and Parvalbumin Expression
   All Authors: Kai-Hua Guo, Dong-Pei Li, Huai-Yu Gu, Jie-Xu, Zhi-Bin Yao*
   Journal: Int J Dev Neurosci. 2014 Jun;35:72-9.
   Publication Year: 2014

Scientific Research Projects
Presided Projects:

1. Research on the Role and Regulatory Mechanism of Nestin Expression in Cholinergic Neurons of the Basal Forebrain during the Course of AD, National Natural Science Foundation of China (31360258), 460,000 yuan (2014-2018).
2. Experimental Study on the Function of Nestin Expression in the Nucleus Basalis of Meynert of Rats and Rhesus Monkeys, Basic Scientific Research Business Fees of Central Universities (11ykpy05), 150,000 yuan (2011-2014).
3. Experimental Study on the Experimental Connection between Nestin Expression in Cholinergic Neurons of the Basal Forebrain and AD Pathology, Natural Science Foundation of Guangdong Province (Doctoral Initiation, S2011040004372, already completed), 30,000 yuan (2011-2013)
4. Morphological, Neurochemical Properties, Fiber Projection and Function Research of Nestin Expression in Neurons of the Nucleus Basalis of Meynert, Natural Science Foundation of Guangdong Province (2015A030313047);
5. Experimental Study on the Intervention Effect and Mechanism of Lycopene on Alzheimer's Disease, Special Fund for Scientific and Technological Development of Guangdong Province (2016A020215036);

Research Topics of Scientific Research Projects:

1. Experimental Study on the Intervention Effect and Mechanism of Lycopene on Alzheimer's Disease, (2016A020215036): Guo Kaihua
   Principal Investigator: Guo Kaihua, Participants: Funding: 100,000 yuan Year: 2016
2. Morphological, Neurochemical Properties, Fiber Projection and Function Research of Nestin Expression in Neurons of the Nucleus Basalis of Meynert (2015A030313047): Guo Kaihua
   Principal Investigator: Guo Kaihua, Participants: Funding: 100,000 yuan Year: 2015