Tutor Qualification:Master's Advisor
Department:Department of histology and embryology
E-mail：yangmzh27@mail.sysu.edu.cn
Research direction:Research on Novel Pluripotent Stem Cells in Large Mammals: Analyzing the Regulation Mechanisms of Stem Cell Pluripotence in Early Embryos of Large Mammals, Developing Optimized Stem Cell Culture Systems, and Establishing Novel Pluripotent Stem Cell Lines for Non Human Primates, Pigs, and Other Large Mammals. Heterogeneic Chimerism Research: Utilizing pluripotent stem cells from non-human primates, pigs, and other large animals, combined with in vitro models such as embryonic models, to study the key obstacles and regulatory mechanisms of mammalian heterologous chimerism, develop and optimize efficient non-human primate pig and other large animal heterologous chimerism technology, in order to cultivate fully functional organs in large animals and provide technical support for the heterologous reconstruction of human organs
Personal profile
Dr. Yang Mingzhu is associate professor and master tutor of Sun Yat-sen School of Medicine, Sun Yat-sen University. In 2021, he graduated from Zhongshan School of Medicine, Sun Yat-sen University and was supervised by Professor Wang Jichang. From 2021 to 2024, he conducted postdoctoral research in Cancer Prevention and Treatment Center of Sun Yat-sen University. Our Research interests include Stem cells and heterogenic chimeric Acids. Some of our research results have been published in international authoritative journals such as Cell Stem Cell, Genome Biology, Cell Reports, Nucleic Acids Research, etc. He has been funded by the National Natural Science Youth Foundation and post-doctoral project.
Main research field
Research on novel pluripotent stem cells in large mammals: To analyze the regulatory mechanism of stem cell pluripotency during the early embryonic process of large mammals, develop an optimized stem cell culture system, and establish new pluripotent stem cell lines in non-human primates, pigs and other large mammals.
Xenochimeric studies: Using non-human primate, pig and other large animal pluripotent stem cells, combined with in vitro models such as embryonoid, to study the key obstacles and regulatory mechanisms of mammalian xenochimerism, develop and optimize efficient non-human primate-pig and other large animal xenochimerism technology, in order to achieve the growth of functional organs in large animals, and provide technical support for human organ xenoreconstruction.
Representative academic achievement
（# co-first author，* co-corresponding author）
- Mingzhu Yang#, Hanwen Yu#, Xiu Yu#, Shiqi Liang#, Yuanlang Hu, Yuxin Luo, Zsuzsanna Izsvák, Chuanbo Sun*, Jichang Wang*. Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.Cell Stem Cell. 2022; 29:400-418.
- Niannian Li# , Kairang Jin# , Bin Liu# , Mingzhu Yang# , PanPan Shi , Dai Heng , Jichang Wang* , Lin Liu* . Single-cell 3D genome structure reveals distinct human pluripotent states. Genome Biol. 2024 May 13;25(1):122.
- Xiu Yu#; Shiqi Liang#; Manqi Chen#; Yu Hanwen; Ruiqi Li; Yuliang Qu; Xuhui Kong; Ruirui Guo; Rongyan Zheng; Zsuzsanna Izsvák; Chuanbo Sun*; Mingzhu Yang#*; Jichang Wang*; Recapitulating early human development with 8C-like cells, Cell Reports, 2022, 39(12): 110994-110994.
- Jia-Li Hu#, He Liang#, Hong Zhang#, Mingzhu Yang#, Wei Sun, Peng Zhang, Li Luo, Jian-Xiong Feng, Huajun Bai, Fang Liu, Tianpeng Zhang, Jin-Yu Yang, Qingsong Gao, Yongkang Long, Xiao-Yan Ma, Yang Chen, Qian Zhong, Bing Yu, Shuang Liao, Yongbo Wang, Yong Zhao, Mu-Sheng Zeng, Nan Cao, Jichang Wang, Wei Chen*, Huang-Tian Yang*, Song Gao*. FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. Nucleic Acids Res. 2020; 48(5):2733-2748.
- Liang S, Yu X, Zhou C, Wang J, Yang M*, Sun C. Protocol for deriving human preimplantation epiblast stem cells and 8-cell embryo-like cells. STAR Protoc. 2024 Nov 15;5(4):103446.
- Chuanbo, Sun#.; Mingzhu, Yang#; Fengying, Qin.; Ruirui, Guo.; Shiqi, Liang.; Hao, Hu*.; Generation of an induced pluripotent stem cell line SYSUi-003-A from a child with epilepsy carrying GRIN2A mutation, Stem Cell Res, 2020, 43: 101706.
- Yu H#, Chen M#, Hu Y#, Ou S#, Yu X, Liang S, Li N, Yang M, Kong X, Sun C, Jia S, Zhang Q, Liu L, Hurst LD, Li R*, Wang W*, Wang J*. Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development. Cell Stem Cell. 2022 Jul 7;29(7):1031-1050.e12.
