Tutor Qualification:Master's Advisor
Department:Department of Biochemistry and Molecular Biology
E-mail：wuxia23@mail.sysu.edu.cn
Research direction:(1) Use cutting-edge omics technology to study the immune cell types, functions and states of the tumor microenvironment in order to discover novel cell types and immune regulatory targets in response to immunotherapy. (2) Develop cutting-edge technologies such as spatial transcriptomics and spatial metabolomics to analyze in situ the dynamic changes of the spatial evolution of the tumor microenvironment in the process of tumor occurrence and development, as well as its molecular regulatory mechanisms, discover novel molecules with spatial distribution characteristics and characterize their functions, so as to discover novel molecular markers and new targets for tumor immunotherapy.
Personal profile
Dr. Wu Xia, Associate Professor and Master Tutor, Sun Yat-sen School of Medicine, Sun Yat-sen University.
Research and Academic work experience:
2024/05 - Now Associate Professor, Sun Yat-sen School of Medicine, Sun Yat-sen University
June 2019 -- April 2024, Sun Yat-sen School of Medicine, Sun Yat-sen University, Distinguished Researcher
2018/06-2019/05, Postdoctoral Fellow, Curie Institute, France, Co-supervisor: Chun_Long Chen, research direction: DNA replication program and genomic instability
2016/10-2018/05, Ecole Normale Superieure, Paris, Postdoctoral fellow, Co-supervisor: Olivier Hyrien. Research interests: DNA replication programs and regulatory mechanisms in Eukaryotes
Educational experience:
2013/10-2016/09 PhD, Biology (Functional Genomics), Ecole Normale Superieure, Paris
2010/09 -- 2013/07 Master, Biophysics, East China Normal University
2006/09 -- 2010/07 Bachelor degree, Biological Sciences, East China Normal University
Academic achievement
Representative research papers:
- Qizhao Huang#, Xia Wu#, Zhiming Wang, Xiangyu Chen, Lisha Wang, Yijun Lu, Dan Xiong, Qiao Liu, Yuhan Tian, Huayu Lin, Junyi Guo, Shuqiong Wen, Wei Dong, Xiaofan Yang, Yuchen Yuan, Zhengliang Yue, Shun Lei, Qing Wu, Ling Ran, Luoyingzi Xie, Yifei Wang, Leiqiong Gao, Qin Tian, Xinyuan Zhou, Beicheng Sun*, Lifan Xu*, Zhonghui Tang*, Lilin Ye*. The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes. Cell, 2022, 185(22): 4049-4066.
- Xia Wu#, Yaqun Liu#, Yves d’Aubenton-Carafa, Claude Thermes, Olivier Hyrien*, Chun-Long Chen*, Nataliya Petryk*. Genome-wide measurement of DNA replication fork directionality and quantification of DNA replication initiation and termination with Okazaki fragment sequencing. Nature Protocols, 2023, 18(4): 1260-1295.
- Wei Dong, Wenyan Li, Shaojin Zhang, Xian Zeng, Qi Qin, Huifeng Fan, Zhonghui Tang, Xia Wu*, Gen Lu*. Exhaustionlike dysfunction of T and NKT cells in Xlinked severe combined immunodeficiency patient with maternal engraftment by singlecell analysis. International Journal of Molecular Medicine, 2023, 51(3).
- Rong Liu, Wei Dong, Dan Xiong, Lanqi Hu, Haoran Zhan, Xiaoping Yuan, Zhonghui Tang, Fang Fu*, Xin Yang*, Xia Wu*. Single-cell RNA-sequencing identifies various proportions of excitatory and inhibitory neurons in cultured human fetal brain cortical tissues. Frontiers in Neuroscience, 2023, 17: 1177747.
- Yuhan Tian#, Xia Wu#, Songhao Luo#, Dan Xiong, Rong Liu, Lanqi Hu, Yuchen Yuan, Guowei Shi, Junjie Yao, Zhiwei Huang, Fang Fu, Xin Yang, Zhonghui Tang, Jiajun Zhang*, Kunhua Hu*. A multi-omic single-cell landscape of cellular diversification in the developing human cerebral cortex. Comput Struct Biotechnol J. 2024, 17(23): 2173-2189.
- Xia Wu#, Hadi Kabalane#, Malik Kahli, Nataliya Petryk, Bastien Laperrousaz, Yan Jaszczyszyn, Guenola Drillon, Frank-Emmanuel Nicolini, Gaelle Perot, Aude Robert, Cedric Fund, Frederic Chibon, Ruohong Xia, Joelle Wiels, Francoise Argoul, Veronique Maguer-Satta, Alain Arneodo, Benjamin Audit*, Olivier Hyrien*. Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions. Nucleic Acids Research, 2018, 46(19): 10157-10172.
Scientific research project
1. Outstanding Youth Project of Natural Science Foundation of Guangdong Province, 2024/01 to 2027/12 million yuan, hosted.
2. National Natural Science Foundation of China Youth Science Fund, 020/01 to 2022/12, 250 yuan, hosted.
3. National Key Research and Development Plan project, 2021/09 to 2020/0829 million yuan, participated.
4. Basic and Applied Basic Research Project of Guangzhou Basic Research Program (General Project), 2020/04 to 2020/03, 50,000 yuan, Host.
5. University Basic Research Funds for Young Teachers Training Project of Sun Yat-sen University, 2020/01 to 2021/12, 200,000 yuan, presided over.
