Tutor Qualification:Master's Advisor
Department:Department of Parasitology
E-mail：shenj29@mail.sysu.edu.cn
Research direction:Study on host immunity against parasitic infection and mechanism of liver damage and repair after infection. The main findings include: 1) It is the first time to discover the immune phenomenon of host immune cells using trogocytosis to kill schistosoma, and elucidates its mechanism; 2) iNOS was identified for the first time as a key immune factor in natural resistance to schistosomiasis infection in rats and its mechanism.
Personal profile
Shen Jia, associate professor and master tutor, Sun Yat-sen School of Medicine, Sun Yat-sen University. She received her bachelor's degree from Southern Medical University and her master's degree from Zhongshan School of Medicine, Sun Yat-sen University. She received her doctorate degree in Microbiology from School of Life Sciences, Sun Yat-sen University in 2017. From 2017 to 2023, he was engaged in postdoctoral and full-time scientific research work in Sun Yat-sen School of Medicine, Sun Yat-sen University, and won the title of Outstanding Postdoctoral Doctor of Sun Yat-sen University in 2018. He has been an associate professor at Sun Yat-sen University since 2024.
Academic achievement
Representative academic works:
- Siyu Zhao#, Yunyi Hu, Bicheng Yang, Lichao Zhang, Meiyining Xu, Kefeng Jiang, Zhun Liu, Mingrou Wu, Yun Huang, Peipei Li, Si-Jia Liang, Xi Sun, Geoff Hide, Zhao-Rong Lun, Zhongdao Wu, Jia Shen*. The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3. Cell Death & Disease, 2024,15(1):75.
- Mei Peng#, Siyu Zhao, Yunyi Hu, Lichao Zhang, Tao Zhou, Mingrou Wu, Meiyining Xu, Kefeng Jiang, Yun Huang, Dinghao Li, Zhao-Rong Lun, Zhongdao Wu, Jia Shen*. Nitric oxide-induced endoplasmic reticulum stress of Schistosoma japonicum inhibits the worm development in rats. Free Radical Biology and Medicine, 2024, 212:295-308.
- Jia Shen#*, Siyu Zhao, Mei Peng, Yanguo Li, Lichao Zhang, Xiaoping Li, Yunyi Hu, Mingrou Wu, Suoyu Xiang, Xiaoying Wu, Jiahua Liu, Beibei Zhang, Zebin Chen, Datao Lin, Huanyao Liu, Wenyan Tang, Jun Chen, Xi Sun, Qi Liao, Geoff Hide, Zhijun Zhou*, Zhao-Rong Lun*, Zhongdao Wu*. Macrophage-mediated trogocytosis contributes to destroying human schistosomes in a non-susceptible rodent host, Microtus fortis. Cell Discovery, 2023, 9(1):101.
- Jia Shen#, Si-Fei Yu, Mei Peng, De-Hua Lai, Geoff Hide, Zhongdao Wu*, Zhao-Rong Lun*. iNOS is essential to maintain a protective Th1/Th2 response and the production of cytokines/chemokines against Schistosoma japonicum infection in rats. PLoS Neglected Tropical Diseases, 2022, 18;16(5):e0010403.
- Siyu Zhao#, Lichao Zhang, Suoyu Xiang, Yunyi Hu, Zhongdao Wu*, Jia Shen*. Gnawing Between Cells and Cells in the Immune System: Friend or Foe? A Review of Trogocytosis. Frontiers in Immunology, 2022/02, 13: 0-791006.
- Mei Peng#, Fang Chen, Zhongdao Wu, Jia Shen*. Endoplasmic Reticulum Stress, a Target for Drug Design and Drug Resistance in Parasitosis. Frontiers in Microbiology, 2021, 12: 670874.
- Jia Shen#, Suoyu Xiang#, Mei Peng, Zhijun Zhou*, Zhongdao Wu*. Mechanisms of resistance to Schistosoma japonicum infection in Microtus fortis, the natural non-permissive host. Frontiers in Microbiology, 2020, 11:2092.
- Jia Shen#, Lifu Wang#, Mei Peng, Zhen Liu, Beibei Zhang, Tao Zhou, Xi Sun*, Zhongdao Wu*. Recombinant Sj16 protein with novel activity alleviates hepatic granulomatous inflammation and fibrosis induced by Schistosoma japonicum associated with M2 macrophages in a mouse model. Parasites & Vectors, 2019，12(1):457.
- Jia Shen#, De-Hua Lai#, R Alan Wilson, Yun-Fu Chen, Li-Fu Wang, Zi-Long Yu, Mei-Yu Li, Ping He, Geoff Hide, Xi Sun, Ting-Bao Yang, Zhong-Dao Wu*, Francisco J Ayala*, Zhao-Rong Lun*. Nitric oxide blocks the development of the human parasite Schistosoma japonicum. PNAS. 2017.114(38):10214-10219.
Award honor
She has presided over seven scientific research projects including the National Natural Science Foundation, the Natural Science Foundation of Guangdong Province and the China Postdoctoral Fund, and participated in the national key research and development project and the 973 Project as the backbone of the subject. First author/corresponding author on Cell Discovery, PNAS, Cell Death & Disease, Free Radical Biology and Medicine, PLOS Neglected Tropical More than 10 SCI papers have been published in international journals such as Diseases, Parasites & Vectors.
