Personal Profile

Medical Doctor, Professor in the Department of Pharmacology and Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, Master's Supervisor, and Doctoral Supervisor. Obtained a Bachelor of Clinical Medicine degree from Capital Medical University in 2005 and a Doctor of Medicine degree from the Department of Pharmacology and Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University in 2010. Serves as an Associate Editor of BMC Anesthesiology, a member of the Executive Committee of the Immunotherapy Branch of the Guangdong Precision Medicine Application Society, and a member of the Professional Committee of the Guangdong Anti-Cancer Association. Also serves as a member of the editorial board for the accompanying "Study Guide and Exercise Book" of the "Pharmacology" textbook published by People's Medical Publishing House. Won the first prize in the National Young Teachers' Teaching Competition organized by the Chinese Pharmacological Society.

Research Areas
The research field is oncopharmacology. The main research directions include basic research and new drug clinical translation of oncolytic virus therapy and induced differentiation therapy for solid tumors.

Main Findings

• Identified immune suppressive cell subtypes and functional molecules that impede the antitumor effect of oncolytic virus M1, and discovered M1 potentiating drugs based on the above mechanisms.
• Proposed the metabolic reprogramming mechanism of the reverse Warburg effect in the differentiation of malignant glioma, discovered new intervention targets and drugs.
• Deciphered the histone acetylation code of malignant glioma differentiation and discovered induced differentiation combination drug strategies based on the chromatin remodeling mechanism.

Supported Projects
Has received support from more than 10 projects, including 4 National Natural Science Foundation projects, 1 major special project of applied scientific research of the Provincial Department of Science and Technology, and 4 Provincial Natural Science Foundation projects.

Publications
Has published more than 60 SCI research papers (as the first or co-first author in 11 papers, and as the corresponding or co-corresponding author in 13 papers), which were published in journals such as Oncogene, Cell Reports, International Journal of Cancer, Molecular Oncology, Cell Death & Disease, Human Gene Therapy, etc. Contributed to the writing of 2 English monographs on brain tumors.

Representative Publications

1. Xincheng Liu, Cui Gu, Tiandong Len, Zhen Fan, Jialuo Ma, Jiehong Chen, Jinhai Xu, Qianyi Li, Bin Jian, Ke Sai, Wenzhuo Yang, Jiayu G, Jingyi Wang, Shuxin Su, Zhijie Che, Yingqian Zhong, Xuanming Liang, Chaoxin Chen, Jing Cai, Yuan Lin, Jiankai Liang, Jun H, Guangmei Yan, Wenbo Zhu* and Wei Yin*. Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell. Cell Death Dis. 2023, 14: 142. （中科院1区TOP）
2. Jiayu Zhang#, Ying Liu#, Jingyi Tan, Yanming Zhang, Chunwa Wong, Ziqing Lin, Xincheng Liu, Max Sander, Xiaozhi Yang, Lebin Liang, Deli Song, Jia Dan, Yuwei Zhou, Jing Cai, Yuan Lin, Jiankai Liang, Jun Hu, Guangmei Yan, Wenbo Zhu*. Necroptotic Virotherapy of Oncolytic Alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC. Oncogene. 2021, 40:4783–4795.（中科院1区TOP）
3. Fan Xing#, Yizhao Luan#, Jing Cai, Sihan Wu, Jialuo Mai, Jiayu Gu, Haipeng Zhang, Kai Li, Yuan Lin, Xiao Xiao, Jiankai Liang, Yuan Li, Wenli Chen, Yaqian Tan,Longxiang Sheng, Bingzheng Lu, Wanjun Lu, Mingshi Gao，Pengxin Qiu, Xingwen Su,Wei Yin, Jun Hu, Zhongping Chen, Ke Sai , Jing Wang, Furong Chen, Yinsheng Chen, Shida Zhu， Dongbing Liu, Shiyuan Cheng, Zhi Xie*, Wenbo Zhu*, Guangmei Yan*. Anti-Warburg Effect Elicited by cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes. Cell Reports, 2017, 18 (2): 468-481. （中科院1区TOP）
4. Wenfeng Liu, Yang Liu, Cheng Hu, Cuiying Xu, Jiehong Chen, Yinting Chen, Jing Cai, Guangmei Yan, Wenbo Zhu*. CTLA-4 Antibody Aggrandizes Antitumor Immune Response of Oncolytic Virus M1 via Targeting Regulatory T Cells. Int. J. Cancer. 2021, 149 (6): 1369-1384.（中科院1区TOP）
5. Shuxin Sun#, Dongdong Xue#, Zhijie Chen, Ying Ou-yang, Ji Zhang, Jialuo Mai, Jiayv Gu, Wanjun Lu, Xincheng Liu, Wenfeng Liu, Longxiang Sheng, Bingzheng Lu, Yuan Lin, Fan Xing, Zhongping Chen, Yonggao Mou, Guangmei Yan, Wenbo Zhu*& Ke Sai*. R406 elicits anti-Warburg effect via Syk-dependent and -independent mechanisms to trigger apoptosis in glioma stem cells. Cell Death & Disease, 2019, 10(358): 1-16. （中科院1区TOP）
6. Wenbo Zhu, Jiankai Liang, Jingyi Tan, Li Guo, Jing Cai, Jun Hu, Guangmei Yan, Yang Liu, Jiayu Zhang, Deli Song, Jia Dan, Chun-Wa Wong, Xingwen Su, Pengxin Qiu, and Yuan Lin*. "Real-Time Visualization and Quantification of Oncolytic M1 Virus In Vitro and In Vivo." Hum Gene Ther. 2021, 32(3-4): 158-165. （中科院2区，封面文章）