Personal Profile

Zhou Ti, female, is a professor in the Biochemistry Teaching and Research Section of the Zhongshan School of Medicine, Sun Yat-sen University. She obtained a Bachelor of Medicine degree in Clinical Medicine from the Zhongshan School of Medicine, Sun Yat-sen University in 2006, and a Doctor of Philosophy degree in Biochemistry from the same university in 2011. From 2008 to 2011, during her doctoral studies, she worked at the Diabetes Research Center of the University of Oklahoma in the United States on the molecular mechanisms of diabetic complications, focusing on the pathological roles and molecular mechanisms of the classical Wnt signaling pathway in diabetic complications and research on gene-targeted therapy.

After obtaining her Ph.D., she stayed at the university as a postdoctoral fellow with a teaching position in 2011 and was awarded the title of "Outstanding Postdoctoral Fellow of Sun Yat-sen University". In 2014, she was selected as a provincial-level training object of the "Thousand, Hundred and Ten Project" of Guangdong Province. In 2015, she was selected as a "Pearl River New Star of Science and Technology in Guangzhou". In 2016, she was selected as a young top-notch talent in the "Hundred, Thousand and Million Talents Project" of Guangdong Province. In 2019, she won the first prize in the "China Biochemistry and Molecular Biology Micro-lecture Open Competition". She also guided undergraduate students to win the second prize and third prize in the "Basic Medical Science Research Design Competition of Sun Yat-sen University" in 2015 and 2019 respectively.

Academic Achievements

1. Di Che#, Zhenzhen Fang#, Li Yan, Jieping Du, Fangping Li, Jinye Xie, Juan Feng, Ping Yin, Weiwei Qi, Zhonghan Yang, Jianxing Ma, Xia Yang*, Guoquan Gao*, Ti Zhou*. Elevated pigment epithelium-derived factor induces diabetic erectile dysfunction via interruption of the Akt/Hsp90β/eNOS complex. Diabetologia. 2020 Sep;63(9):1857-1871. （JCRQ1，TOP，IF:10.1）
2. Jinye Xie#, Liangping Xia#, Wei Xiang#, Wenzhuo He#, Haofan Yin, Fang Wang, Tianxiao Gao, Weiwei Qi, Zhonghan Yang, Xia Yang*, Ti Zhou*, Guoquan Gao*. Metformin Selectively Inhibits Metastatic Colorectal Cancer With the KRAS Mutation by Intracellular Accumulation Through Silencing MATE1. PNAS. 2020 Jun 9;117(23):13012-13022 （JCRQ1，TOP，IF:11.2）
3. Haofan Yin#, Tianxiao Gao#, Jinye Xie#, Zhijian Huang, Xiaoyan Zhang, Fengyu Yang, Weiwei Qi1, Zhonghan Yang, Ti Zhou*, Guoquan Gao*, Xia Yang*. FUBP1 promotes colorectal cancer stemness and metastasis via DVL1-mediated activation of Wnt/beta-catenin signaling. Mol Oncol. 2021 Dec;15(12):3490-3512（JCRQ1，IF:6.6）
4. Chuanghua Luo#, Haofan Yin#, Tianxiao Gao#, Caiqi Ma, Junxi Liu, Ting Zhang, Zumin Xu, Xi Wang, Danrui Zhang, Weiwei Qi, Zhonghan Yang, Guoquan Gao, Xia Yang, Ti Zhou*. PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor. Cell Death Dis. 2021 Mar 17;12(4):295. （JCRQ1，IF:8.4）
5. Gang Shen#, Yanmei Li#, Fuyan Hong, Jing Zhang, Zhenzhen Fang, Wei Xiang, Weiwei Qi, Xia Yang, Guoquan Gao, Ti Zhou*. A role for Snail-MnSOD axis in regulating epithelial-to-mesenchymal transition markers expression in RPE cells. Biochem Biophys Res Commun. 2021 Dec 31;585:146-154. （JCRQ2，IF:3.5）
6. Di Che#, Ti Zhou#, Yuqing Lan, Jinye Xie, Haijun Gong, Chaoyang Li, Juan Feng, Honghai Hong, Weiwei Qi, Caiqi Ma, Qiyuan Wu, Xia Yang*, Guoquan Gao*. High glucose-induced epithelial-mesenchymal transition contributes to the upregulation of fibrogenic factors in retinal pigment epithelial cells. Int J Mol Med, 2016, Dec;38(6):1815-1822.（JCRQ2，IF:4.1）
7. Honghai Hong#，Ti Zhou#，Shuhuan Fang#, Minghan Jia, Zumin Xu, Zhiyu Dai ,Cen Li, Shuai Li,  Lei Li, Ting Zhang, Weiwei Qi, Adham Sameer A. Bardeesi, Zhonghan Yang, Weibin Cai*, Xia Yang*, Guoquan Gao*. Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin. Breast Cancer Res Treat. 2014 Nov;148(1):61-72. （JCRQ2，IF 4.8）
8. Shuai Li#, Ti Zhou#, Cen Li, Zhiyu Dai, Di Che, Yachao Yao, Lei Li, Jianxing Ma, Xia Yang*, Guoquan Gao*. High metastatic gastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS One. 2014 May 13;9(5):e97330. （JCRQ2，IF 3.2）
9. Zhiyu Dai#, Ti Zhou#, Cen Li, Weiwei Qi, Yuling Mao, Juling Lu, Yachao Yao,Lei Li, Ting Zhang, Honghai Hong, Shuai Li, Weibin Cai, Zhonghan Yang, Jianxing Ma, Xia Yang*, Guoquan Gao*. Intracellular pigment epithelium-derived factor contributes to triglyceride degradation. Int J Biochem Cell Biol. 2013 Sep;45(9):2076-86. （JCRQ2，IF 5.0）
10. T. Zhou, X. He, R. Cheng, B. Zhang, R. R. Zhang, Y. Chen, Y. Takahashi, A. R. Murray, K. Lee, G. Gao, J-x. Ma*. Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy. Diabetologia. 2012 Jan;55(1):255-66. （JCRQ1，TOP，IF:10.1）
11. Ti Zhou, Yang Hu, Ying Chen, Kevin K. Zhou, Bin Zhang, Guoquan Gao*, Jian-xing Ma*. The pathogenic role of the canonical Wnt pathway in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4371-9（JCRQ1，IF:4.7）
12. T. Zhou, K. K. Zhou, K. Lee, G. Gao, T. J. Lyons, R. Kowluru, J-x. Ma*. The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy. Diabetologia. 2011 Feb;54(2):459-68. （JCRQ1，TOP，IF:10.1）

Textbooks and Monographs

• Biochemistry (3rd Edition) for undergraduate nursing students, a planned textbook published by People's Medical Publishing House.
• Biochemistry, a planned textbook for biochemistry in national higher medical colleges and universities, published by Science Press.
• Biochemistry and Molecular Biology, a digital planning textbook for national higher education in medicine (National Medical E-Book), published by the National Higher Education Medical Digital Planning Editorial Board.
• Biochemistry and Molecular Biology: A Concise Overview and Synchronized Exercises, published by China Medical Science and Technology Press.
• Experimental Techniques in Medical Molecular Biology, published by People's Medical Publishing House.
• Biochemistry and Biochemistry Experiment Manual, published by Zhengzhou University Press.
• Experimental Guidance and Exercise Book for Medical Cell Biology, published by People's Medical Publishing House.

Research Projects

• ​Research Direction: Metabolic Diseases and Organ Damage
• ​Chief Investigator: As the principal investigator, has hosted a total of 7 fund projects at or above the provincial and ministerial levels, including 3 funded by the National Natural Science Foundation of China. Published 36 SCI papers in journals such as PNAS, Diabetologia, and CDD, including 14 as corresponding author or first author (including co-first author), with 7 in Q1 area (4 of which have an Impact Factor > 10).

Academic Affiliations

• Vice Chairman of the Youth Committee of the Teaching Committee of Biochemistry and Molecular Biology, Chinese Society of Biochemistry and Molecular Biology.
• Expert of the Basic Discipline Group of the International Medical Education Branch of the China Association of International Exchange of Education.
• Member of the Ninth Committee of the Guangdong Provincial Association for Science and Technology.
• Member of the Diabetes Professional Committee of the Guangdong Female Physicians Association.
• Young Editor of the Journal of Military Medicine.