Personal profile
Associate Professor, Master tutor, Sun Yat-sen Medical School, Sun Yat-sen University. He received his doctorate degree from Sun Yat-sen University in 2017, and worked as a postdoctoral fellow and special associate researcher at Sun Yat-sen University from 2017 to 2023. The research direction is to study the therapeutic mechanism and functional regulation of mesenchymal stem cells, focusing on the key bottlenecks restricting the clinical transformation of mesenchymal stem cells. The main academic achievements include: revealing the mechanism of mesenchymal stem cells activating cholinergic anti-inflammatory pathway; Aiming at the functional heterogeneity of mesenchymal stem cells from different tissues, the functional characteristics and therapeutic mechanisms of different tissues were analyzed. Precise targeted delivery strategy of mesenchymal stem cells. Published as first or corresponding author in international journals such as Signal Transduct Target Ther, Mol Ther, Cell Prolif, etc. He presided over the National Natural Science Foundation project and youth project, and the natural science project of Guangdong Province. He won the first prize of Natural Science of Guangdong Province and the Guangdong Medical Science and Technology Award.

Academic achievement
The main academic achievements include: revealing the mechanism of activation of cholinergic anti-inflammatory pathway by mesenchymal stem cells; Aiming at the functional heterogeneity of mesenchymal stem cells from different tissues, the functional characteristics and therapeutic mechanisms of different tissues were analyzed. Precise targeted delivery strategy of mesenchymal stem cells. Published as first or corresponding author in international journals such as Signal Transduct Target Ther, Mol Ther, Cell Prolif, etc. He presided over the National Natural Science Foundation project and youth project, and the natural science project of Guangdong Province. He won the first prize of Natural Science of Guangdong Province and the Guangdong Medical Science and Technology Award. Representative works:

1. Xiaoran Zhang, Xuxia Wei, Yiwen Deng, Xiaofeng Yuan, Jiahao Shi, Weijun Huang, Jing Huang, Xiaoyong Chen,  Shuwei Zheng, Jieying Chen, Keyu Chen, Shiyue Li, Huimin Yi*,  Andy Peng Xiang*. Mesenchymal Stromal Cells Alleviate Acute Respiratory Distress Syndrome through the Cholinergic  Anti-Inflammatory Pathway. Signal Transduct Target Ther. 2022 Sep 5; 7 (1) : 307.

2. Zhang X#, Huang W#, Chen X#, Lian Y, Wang J, Cai C, Huang L, Wang T, Ren J*,  Xiang AP*. CXCR5-Overexpressing Mesenchymal Stromal Cells Exhibit Enhanced Homing and Can Decrease Contact  Hypersensitivity. Molecular Therapy, 2017, 25(6):1434-1447.

3. Jieying Chen#, Jing Huang#, Jiahao Shi, Minrong Li, Erming Zhao, Gang Li, Xiaoyong Chen, Tao Wang, Qiaojia Li,  Weiqiang Li, Jianping Ma, Wenzhe Mao, Rui Fang, Jiang Hao, Weijun Huang, Andy Peng Xiang*,  Xiaoran Zhang*. Nestin+ Peyer's patch resident MSCs enhance healing of inflammatory bowel disease through IL-22-mediated  intestinal epithelial repair. Cell Prolif. 2023 Feb; 56(2):e13363.

4. Jing Huang#, Ronghai Deng#, Weiqiang Li, Meihua Jiang, Andy Peng Xiang,  Xiaoran Zhang*. Nestin+ Mesenchymal Precursors Generate Distinct Spleen Stromal Cell Subsets and Have Immunomodulatory  Function. Int J Mol Sci. 2022 Oct 5; 23 (19) : 11819.

5. Li Q#, Lian Y#, Deng Y, Chen J, Wu T, Lai X, Zheng B, Qiu C, Peng Y, Li W, Xiang AP*, Zhang X*,  Ren J*. mRNA-engineered mesenchymal stromal cells expressing CXCR2 enhances cell migration and improves recovery in  inflammatory bowel disease. Mol Ther Nucleic Acids. 2021 Jul 21; And 2-236.

6. Liao Y#, Li G#, Zhang X#, Huang W, Xie D, Dai G, Zhu S, Lu D, Zhang Z, Lin J, Wu B, Lin W, Chen Y, Chen Z, Peng C,  Wang M, Chen X*, Jiang MH*, Xiang AP*;  Cardiac Nestin(+) Mesenchymal Stromal Cells Enhance Healing of Ischemic Heart through Periostin-Mediated M2 Macrophage  Polarization. Molecular Therapy, 2020, 28(3): 855-873.

7. Yinhong Zhu#, Xiaoran Zhang#, Shujuan Xie#, Weijia Bao, Jingrou Chen, Qili Wu, Xiaorong Lai, Longshan Liu,  Shiqiu Xiong,  Yanwen Peng*. Oxidative Phosphorylation Regulates Interleukin-10 Production in Regulatory B Cells via the Extracellular  Signalrelated Kinase Pathway. Immunology. 2022 Jul 28.

Scientific research project
1. National Natural Science Foundation of China, 2012/01-2025/12, Project Leader;

2. Youth Science Foundation of National Natural Science Foundation of China, 2010/01-2022/12, Project leader;

3. General Project of Natural Science Foundation of Guangdong Province, 2022-01-2024/12, Project leader;

4. Guangzhou Basic and Applied Basic Research Project, 2023/04-2025/03, Project leader;

5. General Project of Natural Science Foundation of Guangdong Province, 2012/01-2023/12, Project leader;

6. Guangzhou Science and Technology Key Research and Development Project, 2022/4-2025/3, subject backbone.