Personal Profile
Yan Guangmei, a professor of pharmacology and doctoral supervisor at Sun Yat-sen University. Professor Yan started working in the Pharmacology Teaching and Research Section of Sun Yat-sen University in 1987. In 1991, he went to the National Institute of Mental Health (NIMH/NIH) of the United States as a visiting scientist. After 1994, he successively worked as a visiting scientist in the Central Nervous System Research Institute of Eli Lilly and Company in the United States and the Department of Pharmacology and Toxicology of Indiana University in the United States. In 1996, he returned to China and enjoyed special allowances from the State Council. He was also funded by the "National Science Fund for Distinguished Young Scholars". In 2002, he became a talent in the first and second tiers of the "Hundred, Thousand and Ten Thousand Talents Project" of the Ministry of Personnel.
He currently serves as a member of the Academic Divisions of the Science and Technology Committee of the Ministry of Education, one of the academic leaders of the national key discipline of pharmacology at the Zhongshan School of Medicine, Sun Yat-sen University, the leader of the national-level excellent course of pharmacology, the director of the Neurosciences Research Center, an editorial board member of the "Chinese Journal of Pharmacology and Toxicology", and the chief editor of the planned textbook "Pharmacology" by the Ministry of Education. He is also an advisor to the United States Pharmacopeia.
Research Directions
Professor Yan Guangmei's main research directions are "New Strategies for Malignant Tumor Treatment: Oncolytic Virus Therapy and Induced Differentiation Therapy" and "Molecular Genetic Mechanism Studies of Ischemic and Hypoxic Brain Injury".
Projects Undertaken
He has successively presided over 25 national and provincial-level projects, including the National Science Fund for Distinguished Young Scholars, key projects of the 863 Program, key projects of the National Natural Science Foundation of China, key projects in key areas of the Guangdong Provincial Department of Science and Technology, and research team projects of the Guangdong Provincial Natural Science Foundation.
Awards and Honors
He has obtained 9 national invention patents and won one third prize from the Ministry of Health and Health Bureaus, one third prize from the Chinese Academy of Medical Sciences, one second prize from the National Education Commission for Scientific and Technological Progress, and one second prize from the Health Bureau of the Higher Education Bureau of Guangdong Province.
Academic Achievements
Professor Yan Guangmei has published more than 90 papers in mainstream academic journals (SCI-indexed) in the fields of tumors and neuroscience, including 70 papers as corresponding/co-corresponding author and 10 papers as the first author. These publications include Nature Biotechnology, Nature Communications, PNAS (2 papers), Journal of Neuroscience, Oncogene, International Journal of Cancer, Molecular Therapy, Molecular Pharmacology (2 papers), etc. He has co-authored two monographs in the field of brain tumorology abroad.
Representative Papers
- Guangmei Yan*, Guojie Zhang, Xiaodong Fang, Yanfeng Zhang, Cai Li, Fei Ling, David N Cooper, Qiye Li, Yan Li, Alain J van Gool, Hongli Du, Jiesi Chen, Ronghua Chen, Pei Zhang, Zhiyong Huang, John R Thompson, Yuhuan Meng, Yinqi Bai, Jufang Wang, Min Zhuo, Tao Wang, Ying Huang, Liqiong Wei, Jianwen Li, Zhiwen Wang, Haofu Hu, Pengcheng Yang, Liang Le, Peter D Stenson, Bo Li, Xiaoming Liu, Edward V Ball, Na An, Quanfei Huang, Yong Zhang, Wei Fan, Xiuqing Zhang, Yingrui Li, Wen Wang, Michael G Katze, Bing Su, Rasmus Nielsen, Huanming Yang, Jun Wang, Xiaoning Wang & Jian Wang. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nature Biotechnology, 2011, 29: 1019-1025. (IF = 39.08)
- Yuan Lin#, Haipeng Zhang#, Jiankai Liang#, Kai Li, Wenbo Zhu, Liwu Fu, Fang Wang, Xiaoke Zheng, Huijuan Shi, Sihan Wu, Xiao Xiao, Lijun Chen, Lipeng Tang, Min Yan, Xiaoxiao Yang, Yaqian Tan, Pengxin Qiu, Yijun Huang, Wei Yin, Xinwen Su, Haiyan Hu, Jun Hu*, and Guangmei Yan*. Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers.PNAS, 2014,111(42):4504-4512.. (IF: 9.809)
- Yan Li, Wei Yin, Xia Wang, Wenbo Zhu, Yijun Huang and Guangmei Yan*: Cholera toxin induces malignant glioma cell differentiation via the PKA/CREB pathway. PNAS, 2007, 104: 13438-43. (IF: 9.809)
- Sihan Wu, Yuan Lin, Dong Xu, Jiesi Chen, Minfeng Shu, Yuehan Zhou, Wenbo Zhu, Xingwen Su, Yuxi Zhou, Pengxin Qiu and Guangmei Yan*. MiR-135a Functions as a Selective Killer of Malignant Glioma. Oncogene, 2012, 31: 3866-3874. (IF = 8.559)
- Haiyan Hu, Yuehan Zhou, Tiandong Leng, Ailing Liu, Youqiong Wang, Xiuhua You, Jingkao Chen, Lipeng Tang, Wenli Chen, Pengxin Qiu, Wei Yin, Yijun Huang, Jingxia Zhang, Liwei Wang, Hanfei Sang and Guangmei Yan*. A major cholesterol metabol i te cholestane-3β, 5α, 6β-triolfunctions as an endogenous neuroprotectant. The Journal of Neuroscience, August 20, 2014, 34(34): 11426 –11438. (IF: 6.747)
- Kai Li#, Haipeng Zhang#, Jianguang Qiu, Yuan Lin, Jiankai Liang, Xiao Xiao,Liwu Fu, Fang Wang, Jing Cai, Yaqian Tan, Wenbo Zhu, Wei Yin, Bingzheng Lu, Fan Xing, Lipeng Tang, Min Yan, Jialuo Mai, Yuan Li, Wenli Chen, Pengxin Qiu, Xingwen Su, Guangping Gao, Phillip W L Tai, Jun Hu* and Guangmei Yan*. Activation of cyclic adenosine monophosphate pathway increases the sensitivity of cancer cells to the oncolytic virus M1. Molecular Therapy, 2016, 24(1): 156–165. (IF =6.227)
Academic works
- Wenbo Zhu and Guangmei Yan (2011). The Molecular Mechanism for Differentiation Therapy of Malignant Glioma, Brain Tumors - Current and Emerging Therapeutic Strategies, Ana L. Abujamra (Ed.), ISBN: 978-953-307-588-4, InTech. Available from: http://www.intechopen.com /articles /show /title /the-molecular-mechanism-for-differentiation-therapy-of-malignant-glioma.
- Sihan Wu, Wenbo Zhu and Guangmei Yan (2012). Evolvement of microRNAs as therapeutic targets for malignant gliomas, Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications. Terry Lichtor. (Ed.),ISBN 980-953-307-523-0, InTech.
Textbooks and Monographs
Chief Editor of Textbooks:
- Chief Editor of "Pharmacology" published by Higher Education Press in 2004.
- Chief Editor of "Pharmacology" published by Higher Education Press in 2009.
Awards and Honors
- The relationship between the structure-activity relationship of central benzodiazepine receptors and photoaffinity labeling, Second Prize for Science and Technology of the Health Bureau of the Higher Education Bureau of Guangdong Province.
- The relationship between the structure-activity relationship of central benzodiazepine receptors and photoaffinity labeling, Second Prize for Scientific and Technological Progress of the National Education Commission.
- Research on central benzodiazepine receptors, Third Prize for Science and Technology of the Chinese Academy of Medical Sciences.
- Isolation and purification of benzodiazepine receptors, preparation of monoclonal antibodies and the localization and distribution of their subunits in the central nervous system, Third Prize of the Ministry of Health and Health Bureau.
Academic Positions
Professor Yan Guangmei currently serves as a member of the Academic Divisions of the Science and Technology Committee of the Ministry of Education, an executive director of the Chinese Pharmacological Society, a member of the American Neurological Association, an advisor to the United States Pharmacopeia, and a new drug review expert in China. In addition, he serves as a reviewer for journals such as Molecular Cancer, Molecular Cancer Therapeutics, and BBAGEN.
