Personal Profile

Wu Zhongdao, male, born in April 1962, Professor (2001), Doctoral Supervisor (2003), member of the Communist Party of China. Current workplace: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University.

He graduated from Nanjing Medical University in July 1997 with a doctorate degree. In August 1997, he went to Sun Yat-sen University of Medical Sciences to conduct postdoctoral research. After completing his postdoctoral studies, he stayed at the university as a teacher. From 1992 to 1993, he was a visiting scholar at the Harvard School of Public Health, Harvard University, USA.

He currently serves as the Director of the Key Laboratory of Tropical Disease Control of the Ministry of Education at Sun Yat-sen University, the Director of the National Atomic Energy Agency Nuclear Technology (Insect Sterility) Research and Development Center, the Director of the Guangdong Province Vector-borne Biological Prevention and Control Engineering Technology Research Center, the Vice Chairman of the Medical Parasitology Branch of the Chinese Preventive Medicine Association and the Head of the Education Group, the Chairman of the Guangdong Parasitological Society, the Vice Chairman of the Guangdong Translational Medicine Association, a member of the Teaching Guidance Committee for Medical Humanities Quality of the Ministry of Education, etc.

He served as the Vice Dean (2003 - 2014) and Party Secretary (May 2015 - June 2021) of the Zhongshan School of Medicine, Sun Yat-sen University.

He has been engaged in the prevention and control of important parasitic diseases. In recent years, he has focused on the research of alien biological control technology. His main research directions include: the study of the immune response regulation and its molecular mechanisms of schistosomes and Angiostrongylus cantonensis to hosts; the research of key technologies for the prevention and control of invasive vector organisms.

He has presided over many projects, including the National "973" Project (2009) and the National Key R & D Program Project (2016). In 2020, he obtained a key project of nuclear technology application (5.2 million yuan, project leader) from the National Defense Science, Technology and Industry Administration.

He has published more than 100 papers in journals such as Nature and PNAS. The research he led, "Study on the Gene Expression Profile of Schistosoma japonicum Strains in Mainland China", won the Second Prize of Natural Sciences of Chinese Universities in 2002 and the Third Prize of Scientific and Technological Progress of Guangdong Province in 2003.

He is the co-editor-in-chief of monographs such as "Schistosomiasis Control in China: The Successful Example of Jiangxi Province" (published by Springer). He is the executive vice editor-in-chief of Journal of Tropical Medicine, the deputy editor-in-chief of Chinese Journal of Parasitology and Parasitic Diseases, and a member of the editorial boards of Parasitology Research, Chinese Journal of Prevention and Control of Parasitic Diseases, Chinese Journal of Zoonoses, and Chinese Journal of Tropical Medicine.

He is the chief editor of the national medical college long-term clinical medicine professional planning textbook "Human Parasitology" (People's Health Publishing House, 3rd and 4th edition editors), the first national digital textbook "Human Parasitology", the national medical college clinical laboratory professional planning textbook "Clinical Parasitological Examination" and "Introduction to Basic Medicine" (Peking University Medical Press, 2020). He is also the deputy editor of the national medical college five-year clinical medicine professional planning textbook "Human Parasitology" (People's Health Publishing House, 8th and 9th editions).

He has won the First Prize of Guangdong Higher Education Teaching Achievement three times. "Human Parasitology" has been identified as a demonstration course of ideological and political education in curriculum by the Ministry of Education (2021, course leader).

He has received the titles of Baosteel Outstanding Teacher and Guangdong Provincial Teaching Master. He is a cross-century talent for local disease prevention and control of the former Ministry of Health, a leading medical talent in Guangdong Province, and an expert entitled to special allowances from the State Council.

Academic Achievements
Important Academic Research Results and Contributions

Research Projects Presided over Since 2011

1. Wu Zhongdao. Study on the Regulatory Effect and Mechanism of Schistosoma japonicum Exosomes on Host Immune Response, National Natural Science Foundation, 81572014, 2016.1 - 2019.12, 600,000 yuan.
2. Wu Zhongdao. NSFC-Guangdong Provincial Government Joint Fund (Phase II) Supercomputer Science Application Research Special Project (Letter of the National Science Foundation [2016] No. 3).
3. Wu Zhongdao. Research on the Biological Characteristics of Invasive Vector Organisms and Their Pathogens Related to Important Tropical Disease Transmission (Project No. 2016YFC1200500), National Key R & D Program, 2016.7 - 2018.12, 12,770,000 yuan.
4. Wu Zhongdao, et al. Study on the Immunoregulatory Mechanism of Angiostrongylus cantonensis Disease (2010CB530004), 973 Project [2010CB530000], 2010.1 - 2014.12, 4,450,000 yuan.
5. Wu Zhongdao, et al. The Role and Mechanism of Microglia in Angiostrongylus cantonensis Disease, National Natural Science Foundation (81271855), 2013.1 - 2016.12, 600,000 yuan.
6. Wu Zhongdao, et al. Experimental Study on the Phylogenetic Relationship, Infection and Pathogenic Mechanism, Molecular Diagnostic Targets and Treatment of Angiostrongylus cantonensis on Both Sides of the Taiwan Strait, International (Regional) Cooperation and Exchange Project (81261160324), 2013.1 - 2016.12, 1,500,000 yuan.
7. Wu Zhongdao, et al. Immune Response of Aged Host T Cells to Schistosome Infection, 2012 NSFC-NIH Biomedical Cooperation Research Project (81261120381), 2013.1 - 2013.12, 300,000 yuan.
8. Wu Zhongdao, Important Parasitic Disease Monitoring Technology Research - Subproject, Infectious Disease Major Special Project (2012ZX10004220 - 003), 2012.12 - 2015.12, 330,000 yuan.

Representative Papers Since 2011

1． Shen J, Lai DH, Wilson RA, Chen YF, Wang LF, Yu ZL, Li MY, He P, Hide G, Sun X, Yang TB, Wu ZD, Ayala FJ, Lun ZR. Nitric oxide blocks the development of the human parasite Schistosoma japonicum. Proc Natl Acad Sci U S A. 2017 Sep 5. pii: 201708578. doi: 10.1073/pnas.1708578114.( IF= 9.661)

2． Liu Z, Su DM, Yu ZL, Wu F, Liu RF, Luo SQ, Lv ZY, Zeng X, Sun X, Wu ZD. Soluble antigens from the neurotropic pathogen Angiostrongylus cantonensis directly induce thymus atrophy in a mouse model. Oncotarget. 2017 Jul 25; 8(30): 48575-48590  (IF= 5.168)

3． Wang L, Xie H, Xu L, Liao Q, Wan S, Yu Z, Lin D, Zhang B, Lv Z, Wu Z, Sun X. rSj16 Protects against DSS-Induced Colitis by Inhibiting the PPAR-α  Signaling  Pathway. Theranostics. 2017 Aug 15;7(14):3446-3460 (IF= 8.712)

4． Yuan D, Wu Z, Wang Y. Evolution of the diacylglycerol lipases. Prog Lipid Res.2016 Aug 26;64:85-97 （IF=11.23）

5． Peng H, Zhang Q, Li X, Liu Z, Shen J, Sun R, Wei J, Zhao J, Wu X, Feng F, Zhong S, Sun X, Wu Z. IL-33 Contributes to Schistosoma japonicum-induced Hepatic Pathology through Induction of M2 Macrophages. Sci Rep. 2016 Jul 21;6:29844. （IF-5.2）

6． Yu L, Wu X, Wei J, Liao Q, Xu L, Luo S, Zeng X, Zhao Y, Lv Z, Wu Z. Preliminary expression profile of cytokines in brain tissue of BALB/c mice with Angiostrongylus cantonensis infection. Parasit Vectors. 2015 Jun 14;8:328 （IF=3.2）

7． Yang F, Long E, Wen J, Cao L, Zhu C, Hu H, Ruan Y, Okanurak K, Hu H, Wei X, Yang X, Wang C, Zhang L, Wang X, Ji P, Zheng H, Wu Z, Lv Z. Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum. Parasit Vectors. 2014 Aug 29;7:407.（IF=3.2）

8． Hui Peng, Rui Sun, Qixian Zhang, Jia Zhao, Jie Wei, Xin Zeng, Huanqin Zheng, Zhongdao Wu. IL-33 mediates type 2 immunity and inflammation in central nervous system of mice infected with Angiostrongylus cantonensis .J Infect Dis 2013 Mar 1;207(5):860-9. (IF=6.41)

9．  Sun XJ, Li R, Sun X, Zhou Y, Wang Y, Liu XJ, Lu Q, Zhou CL, Wu ZD. Unique roles of Schistosoma japonicum protein Sj16 to induce IFN-γ and IL-10 producing CD4(+) CD25(+) regulatory T cells in vitro and in vivo. Parasite Immunol. 2012 Aug;34(8-9):430-9 (IF=2.6)

10．  Liao Q, Yuan X, Xiao H, Liu C, Lv Z, Zhao Y, Wu Z. Identifying Schistosoma japonicum excretory/secretory proteins and their interactions with host immune system. PLoS One. 2011;6(8):e23786. (IF=4.4)

11． Liao Q, Liu C, Yuan X, Kang S, Miao R, Xiao H, Zhao G, Luo H, Bu D, Zhao H, Skogerbø G, Wu Z, Zhao Y. Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network. Nucleic Acids Res. 2011 May;39(9):3864-78 （If=7.7）

Textbooks and Monographs

Academic Works and Textbooks:

1. Heinz Mehlhorn, Zhongdao Wu, Bi Ye. Treatment of Human Parasitosis in Traditional Chinese Medicine. Springer, 2014.
2. Chief Editor of the first national medical e-textbook "Human Parasitology" digital textbook (Edition 1), People's Military Medical Publishing House, 2016.
3. Chief Editor of "Human Parasitology" for the long-term clinical medical program of national higher medical colleges (Edition 3), People's Health Publishing House, 2015.
4. Chief Editor of "Clinical Parasitological Examination" (Textbook for Inspection Majors of National Higher Medical and Pharmaceutical Colleges) (Edition 3), China Medical Science and Technology Publishing House, 2015.
5. Deputy Chief Editor of the national higher medical colleges planning textbook "Human Parasitology" (Chief Editors: Zhu Xinping, Su Chuan), People's Health Publishing House, 2014.
6. Deputy Chief Editor of "Medical Parasitology" (Chief Editor: Wang Shiping: National Higher Medical Colleges Planning Textbook), Higher Education Publishing House, 2014.
7. Deputy Chief Editor of "Medical Microbiology and Parasitology" (Chief Editor: Wang Shiping), Science Publishing House, 2006.
8. Co-author of "Modern Infectious Diseases and Infectious Diseases" (Chief Editor: Peng Wenwei), Science Publishing House, 2000.
9. Co-author of "Principles and Techniques of In Vitro Culture" (Chief Editor: Xue Qingshan), Science Publishing House, 2001.
10. Co-author of "Theories and Practices of Schistosomiasis Prevention and Control" (Chief Editors: Yuan Hongchang, Zhang Shaoji), Fudan University Publishing House, 2003.
11. Co-author of "Parasitic Infection and Clinical Practice" (Chief Editor: Shen Yiping), People's Health Publishing House, 2007.
12. Co-author of "Schistosoma Infection Immunity" (Chief Editors: Zhu Yinchang, Wu Guanling), Shanghai Scientific and Technical Literature Publishing House, 2008.

Awards and Honors
Wu Zhongdao et al. "Study on the Gene Expression Profile of Schistosoma japonicum Strains in Mainland China", Second Prize of Natural Sciences of Chinese Universities in 2002, Third Prize of Scientific and Technological Progress of Guangdong Province in 2003.

Academic Positions
Member of the Council of the Chinese Endemic Diseases Association, Executive Director and Head of the Education Group of the Parasitology Branch of the Chinese Preventive Medicine Association, Member of the Council of the Chinese Medical Association Tropical Diseases and Parasitology Branch, Vice Chairman of the Guangdong Parasitological Society; Executive Editor of Tropical Medicine Journal, Editorial Board Member of Parasitology Research, Chinese Journal of Tropical Diseases, Chinese Journal of Schistosomiasis Prevention and Control, Chinese Journal of Zoonoses, International Journal of Medical Parasitology, and Journal of Parasitology and Medical Entomology. Reviewer of the National Natural Science Foundation, etc.