Department:Department of Biochemistry and Molecular Biology
E-mail:tianhan@mail2.sysu.edu.cn
Research direction:It is a key regulatory mechanism for malignant progression and metastasis of tumors, as well as the discovery of potential tumor diagnostic and therapeutic targets.
Personal Information
- Associate Professor, Zhongshan School of Medicine, Sun Yat-sen University, Sep 2021 - Present
- Distinguished Assistant Researcher/Associate Researcher, Zhongshan School of Medicine, Sun Yat-sen University, Jul 2016 - Aug 2021
- Doctoral Candidate, Major in Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Sep 2011 - Jun 2016
- Undergraduate Student, Major in Biological Science, School of Life Sciences, Sun Yat-sen University, Sep 2007 - Jun 2011
Research Interests
Focused on the key regulatory mechanisms underlying the malignant progression and metastasis of tumors, as well as the discovery of potential molecular targets for tumor diagnosis and treatment. As the corresponding author or first author (including co-first author), have published 3 papers in important academic journals such as Journal of Clinical Investigation and Nature Communications. The research achievements won the First Prize of Guangdong Natural Science Award (as the fourth contributor). Also, as the project leader, have received funding from multiple funds including the National Natural Science Foundation of China (General Program and Youth Program) and Guangdong Natural Science Foundation.
Academic Achievements
As the corresponding author or first author (including co-first author), have published 3 papers in important academic journals such as Journal of Clinical Investigation and Nature Communications. The research achievements won the First Prize of Guangdong Natural Science Award (as the fourth contributor). Also, as the project leader, have received funding from multiple funds including the National Natural Science Foundation of China (General Program and Youth Program) and Guangdong Natural Science Foundation.
Representative Academic Publications
- Lei Liu#, Tianyu Tao#, Shihua Liu#, Xia Yang, Xuwei Chen, Jiaer Liang, Ruohui Hong, Wenting Wang, Yi Yang, Xiaoyi Li, Youhong Zhang, Quanfeng Li, Shujun Liang, Haocheng Yu, Yun Wu, Xinyu Guo, Yan Lai, Xiaofan Ding, Hongyu Guan, Jueheng Wu, Xun Zhu, Jie Yuan, Jun Li, Shicheng Su, Mengfeng Li, Xiuyu Cai*, Junchao Cai*, Han Tian*. An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness. Nature Communications. 2021 May 11;12(1):2693.
- Han Tian#, Rong Lian#, Yun Li#, Chenying Liu, Shujun Liang, Wei Li, Tianyu Tao, Xingui Wu, Yaokai Ye, Xia Yang, Jian Han, Xuwei Chen, Jun Li, Yukai He, Mengfeng Li, Jueheng Wu*, Junchao Cai*. AKT-induced lncRNA VAL promotes EMT-independent metastasis through diminishing Trim16-dependent Vimentin degradation. Nature Communications. 2020 Oct 12;11(1): 5127.
- Zhe Ying#, Han Tian#, Yun Li, Rong Lian, Wei Li, Shanshan Wu, Hui-Zhong Zhang, Jueheng Wu, Lei Liu, Junwei Song, Hongyu Guan, Junchao Cai, Xun Zhu, Jun Li, Mengfeng Li*. CCT6A suppresses SMAD2 and promotes prometastatic TGF-β signaling. Journal of Clinical Investigation. 2017 May 1;127(5):1725 - 1740.