Personal Profile

Dr. Tang Zhonghui, a professor in the Zhongshan School of Medicine, Sun Yat-sen University, and a doctoral supervisor.

Recipient of the Overseas High-level Talent Introduction Program

His main research directions are as follows:

To reveal how the three-dimensional spatial structure of chromatin regulates gene transcription, to understand how the disruption of chromatin spatial structure caused by genetic variations leads to the occurrence and development of diseases, and to expand the potential application value of three-dimensional genomics research in precision medicine;

To develop in situ omics techniques and algorithms for tissues, and conduct three-dimensional spatial visualization and quantitative analysis of functional molecules, so as to study the regulatory mechanisms by which functional molecules regulate the spatial evolution of the tissue microenvironment during organ development and tumor progression.

Professor Tang Zhonghui has published three papers as the first/corresponding author in Cell (in 2013, 2015, and 2022).

Discipline: Molecular Medicine and Bioinformatics

Recruitment of Postdoctoral Fellows/Researchers: Our team welcomes postdoctoral fellows/researchers who are good at independent thinking, willing to challenge themselves, and possess a collaborative spirit to join us. Our team focuses on the development of new technologies and algorithms in cutting-edge omics and important clinical issues in tumor immunology. The team has an interdisciplinary environment integrating statistics, computer science, biology, and medicine.

Academic Publications

1. Qizhao Huang*, Xia Wu*, Zhiming Wang*, Xiangyu Chen*, Lisha Wang, Yijun Lu, Dan Xiong, Qiao Liu, Yuhan Tian, Huayu Lin, Junyi Guo, Shuqiong Wen, Wei Dong, Xiaofan Yang, Yuchen Yuan, Zhengliang Yue, Shun Lei, Qing Wu, Ling Ran, Luoyingzi Xie, Yifei Wang, Leiqiong Gao, Qin Tian, Xinyuan Zhou, Beicheng Sun#, Lifan Xu#, Zhonghui Tang#, Lilin Ye#. (2022). The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes. Cell 185:4049-4066 (#co-corresponding authors).
2. Tang Z*, Luo OJ*, Li X*, Zheng M, Zhu JJ, Szalaj P, Trzaskoma P, Magalska A, Wlodarczyk J, Ruszczycki B, et al. (2015). CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription. Cell 163:1611-27 (*co-first authors).
3. Kieffer-Kwon KR*, Tang Z*, Mathe E*, Qian J*, Sung MH*, Li G, Resch W, Baek S, Pruett N, Grøntved L, et al. (2013). Interactome Maps of Mouse Gene Regulatory Domains Reveal Basic Principles of Transcriptional Regulation. Cell 155:1507-20. (*co-first authors, cover story).
4. Menghi F, Barthel FP, Yadav V, Tang M, Ji B, Tang Z, Carter GW, Ruan Y, Scully R, Verhaak RGW, Jonkers J, Liu ET. (2018). The tandem duplicator phenotype is a prevalent genome-wide cancer configuration driven by distinct gene mutations. Cancer Cell 34:197-210.
5. Vian L, Pękowska A, Rao SSP, Kieffer-Kwon KR, Jung S, Baranello L, Huang SC, El Khattabi L, Dose M, Pruett N, Sanborn AL, Canela A, Maman Y, Oksanen A, Resch W, Li X, Lee B, Kovalchuk AL, Tang Z, Nelson S, Di Pierro M, Cheng RR, Machol I, St Hilaire BG, Durand NC, Shamim MS, Stamenova EK, Onuchic JN, Ruan Y, Nussenzweig A, Levens D, Aiden EL, Casellas R. (2018). The Energetics and Physiological Impact of Cohesin Extrusion. Cell 173:1165-1178.
6. Vahedi G, Kanno Y, Furumoto Y, Jiang K, Parker SC, Erdos MR, Davis SR, Roychoudhuri R, Restifo NP, Gadina M, Tang Z, Ruan Y, Collins FS, Sartorelli V, O'Shea JJ (2015). Super-enhancers delineate disease-associated regulatory nodes in T cells. Nature 520:588-562.
7. Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon KR, Resch W, Liang G, Tang Z, Mathé E, Benner C, et al. (2014). B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity. Cell 159:1524-1537.