Current Position: Associate Professor, Department of Physiology, Zhongshan School of Medicine, Sun Yat-sen University

Address: Room 725, Science and Technology Building, No. 74 Zhongshan Second Road, Guangzhou City, Guangdong Province, 510080

Email Address: luguang5@mail.sysu.edu.cn

ORCID: https://orcid.org/0000-0002-2268-1033

ResearchGate: https://www.researchgate.net/profile/Guang-Lu-2

Educational and Professional Background

• Employed as a talent introduced under the "Hundred Talents Program" of Sun Yat-sen University in 2022.
• Conducted postdoctoral research at the National University of Singapore from 2019 to 2022. Supervisor: Professor Han Ming Shen
• Graduated from the National University of Singapore in 2019 with a Doctor of Philosophy degree. Supervisor: Professor Han Ming Shen
• Graduated from Peking University in 2015 with a Master's degree. Supervisor: Professor Gen Ze Shao
• Graduated from Sun Yat-sen University in 2012 with a Bachelor of Medicine degree, minoring in Medical Nutrition

Main Research Interests

(1) Protein Modification and Autophagy Regulation: Research on post-translational modifications (such as ubiquitination, phosphorylation, etc.) of key autophagy regulatory proteins, regulation of their stability, and functional studies.
(2) Mitochondrial Quality Control and Aging: Research on the molecular regulatory mechanisms of mitochondrial quality control and their roles in the occurrence and development of aging-related diseases such as neurodegenerative diseases.

Published multiple papers as the first author (including co-first author) and corresponding author in journals such as Trends in Cell Biology (IF: 19.0), Autophagy (IF: 13.3, 4 papers), Nucleic Acids Research (IF: 14.9), Medcomm (IF: 9.9), Stem Cell Reports (IF: 5.9), Life Metabolism, and Liver Research.

Served as an independent reviewer for multiple journals including Trends in Cell Biology, Autophagy, Communication Biology, Cell & Bioscience, Pharmacological Research, Journal of FASEB, International Journal of Biological Science, Burns Trauma, Cell Death Dis., Journal of Cellular Physiology, etc.

Research Projects Undertaken

• General Project of the National Natural Science Foundation of China, Principal Investigator, 2025 - 2028
• General Project of the Guangdong Natural Science Foundation, Principal Investigator, 2025 - 2027
• Overseas Talent Introduction Special Project, Principal Investigator, 2024 - 2026
• Young Cultivation Project of Sun Yat-sen University (Central University), Principal Investigator, 2024
• Young Project of Guangzhou Science and Technology Bureau, Principal Investigator, 2023 - 2024
• Young Project of the Guangdong Natural Science Foundation, Principal Investigator, 2023 - 2025
• Startup Fund of the "Hundred Talents Program" of Sun Yat-sen University, Principal Investigator, 2022 - 2024

Awards Received

• Outstanding Clinical Teaching Teacher of Ke Lin Medical Education Foundation (2024)
• Outstanding Class Teacher of Sun Yat-sen University (2024)
• Second Prize in the Teaching Competition of Sun Yat-sen University (2024)
• Second Prize in the Undergraduate Course Lesson Plan Competition of Zhongshan School of Medicine (2024)
• "Outstanding Class Teacher at the College Level" of Zhongshan School of Medicine (2024)
• "Outstanding Teaching Competition Award" of Zhongshan School of Medicine (2024)
• Second Prize in the Teaching Competition of Zhongshan School of Medicine (2023)

Published Papers (#Co-first author, *Corresponding author)

2024

• Yi J#, Wang H#, Lu G#, Zhang H, Wang L, Wang L, Wu Y, Xia D, Fang EF, Shen HM: Spautin-1 promotes PINK1-Parkin-dependent mitophagy and improves memory in an Alzheimer’s disease animal model. Autophagy 2024 (IF: 13.3)
• Ni H#, Tang S#, Lu G#, Niu Y, Xu J, Zhang H, Hu J, Shen HM, Wu Y, Xia D: Linc00673-V3 positively regulates autophagy by promoting Smad3 mediated LC3B transcription in NSCLC. Life Science Alliance 2024 (IF: 4.4)
• N Zheng, S Liu, J Chen, Y Xu, W Cao, J Lin, G Lu, Zhang G: SARS-CoV-2 NSP2 as a Potential Delivery Vehicle for Proteins. Molecular Pharmaceutics 2024 (IF: 4.9)

2023

• Tan HWS#, Lu G#, Shen HM: A novel mitochondrial quality control pathway: Autophagic secretion of mitochondria (ASM). Mitochondrial Communications 2023;1;13 - 15
• Tan HWS#, Lu G#, Shen HM: Autophagic secretion of mitochondria (ASM): An alternative way for getting rid of damaged mitochondria. Autophagy 2023;19(2);739 - 741. (IF: 13.3)
• Lu G, Shen HM: CLN3 clinches lysosomes in clearance of glycerophospholipids. Life Metabolism 2023; loac029.
• Wu Y#, Tan HWS#, Lin JY, Shen HM, Wang HH, Lu G*: Molecular mechanisms of autophagy and implications in liver diseases. Liver Research 2023; 7(1); 56 - 70
• Chuah YH, Tay EXY, Grinchuk OV, Yoon J, Feng J, Kannan S, Robert M, Jakhar R, Liang Y, Lee BWL, Wang LC, Lim YT, Zhao T, Sobota RM, Lu G, Low BC, Crasta KC, Verma CS, Lin Z, Ong DST: CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma. Cell Death Differentiation 2023 (IF: 12.4)
• Chen K, Yuan X, Wang S, Zheng F, Fu Z, Shen Z, Cheng X, Wang Y, Tang S, Ni H, Wang F, Lu G, Wu Y, Xia D, Lu W: MAP4K4 promotes ovarian cancer metastasis through diminishing ADAM10-dependent N-cadherin cleavage. Oncogene 2023; 42(18):1438 - 1452 (IF: 8.0)

2022

• Lu G#, Tan HWS#, Schmauck-Medina T, Wang L, Chen J, Cho YL, Chen K, Zhang JZ, He W, Wu Y, Xia D, Zhou J, Fang EF, Fang L, Liu W, Shen HM: WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP. Autophagy 2022; 18(12), 2865 - 2879. (IF: 13.3)
• Lu G#, Wang Y#, Shi Y#, Huang CH, He W, Wang C, Shen HM: Autophagy in health and disease: from molecular mechanisms to therapeutic target. Medcomm 2022; 3(3), e150 (IF: 9.9)
• Tan HWS, Lu G, Dong H, Cho YL, Natalia A, Wang L, Chan C, Kappei D, Taneja R, Ling SC, Shao H, Tsai SY, Ding WX, Shen HM: A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery. Nature Communications 2022; 13(1): 1 - 17. (IF: 16.6)
• Ouyang C, Lu G, He W, Bay BH, Shen HM: Post-translational Modification in Control of SIRT1 Stability during DNA Damage Response. International Journal of Biological Science 2022;18(7):2655 - 69. (IF: 9.2)
• Chen J, Zou Li, Lu G, Grinchuk O, Fang L, Ong D, Taneja R, Ong CN, Shen HM: PFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation. Cell Discovery 2022; 8(1): 1 - 16. (IF: 33.5)
• Zhou J, Feng J, Wu Y, Dai HQ, Zhu GZ, Chen PH, Wang LM, Lu G, Liao XW, Lu PZ, Su WJ, Hooi SC, Ye XP, Shen HM, Peng T, Lu GD: Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy. Experimental & Molecular Medicine 2022 (IF: 12.8)

Main Papers Published before Joining Sun Yat-sen University

• Lu G, Wang L, Zhou J, Liu W, Shen HM: A Destiny for Degradation: Interplay between Cullin-RING E3 Ligases and Autophagy. Trends in Cell Biology 2021; 31(6), 432 - 444. (IF: 19.0)
• Lu G, Yi J, Andrea G, Wang YT, Wu Y, Ren Y, Wu M, Shi Y, Ouyang C, Tan HWS, Wang T, Wang L, Yang ND, Deng S, Xia D, Chen RH, Tooze SA, Shen HM: Suppression of autophagy during mitosis via CRL4s-mediated WIPI2 polyubiquitination and proteasomal degradation. Autophagy 2019;15(11):1917 - 1934. (IF: 13.3)
• Yi J#, Lu G#, Li L, Wang X, Cao L, Lin M, Zhang S, Shao G: DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation. Nucleic Acids Research 2015; 43(9);4579 - 4590. (IF: 14.9)
• Wu M#, Lu G#, Lao YZ#, Zhang H, Zheng D, Zheng ZQ, Yi J, Xiang Q, Wang L, Tan H, Zhou H, Shen HM, Xu HX: Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice. Acta Pharmacologica Sinica 2021; 42(2); 199 - 208. (IF: 8.2)
• Li M#, Lu G#, Hu J#, Shen X, Ju J, Gao Y, Qu L, Xia Y, Chen Y, Bai Y: EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy. Stem Cell Reports 2016; 6(3);396 - 410. (IF: 5.9)
• Klionsky D J, Abdel-Aziz AK,...Lu G,...& Bartek J: Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 01/2021;17(1): 1 - 382. (Guideline article in the autophagy field, IF: 13.3)