Tutor Qualification:Master's Advisor
Department:Sun Yat-sen Medical College
E-mail:laibqin@mail.sysu.edu.cn
Research direction:Spinal cord injury repair focuses on the cutting-edge exploration of stem cell tissue engineering technology and the theoretical research of nerve regeneration function reconstruction.
Personal Profile
Associate Professor and Master's Supervisor at Zhongshan School of Medicine, Sun Yat-sen University. He earned his Bachelor's degree from Southern Medical University and his Ph.D. in Medicine from Sun Yat-sen University. From 2014 to 2022, he worked as a full-time researcher (Postdoctoral Fellow and Special-Term Researcher) at Zhongshan School of Medicine.
Academic Achievements
Representative Publications:
- Lai BQ, Zeng X, Han WT, Che MT, Ding Y, Li G, Zeng YS. Stem cell-derived neuronal relay strategies and functional electrical stimulation for treatment of spinal cord injury. Biomaterials. 2021, 279: 12121. (CAS Q1, IF: 15.304)
- Lai BQ, Bai YR, Han WT, Zhang B, Liu S, Sun JH, Liu JL, Li G, Zeng X, Ding Y, Ma YH, Zhang L, Chen ZH, Wang J, Xiong Y, Wu JH, Qi Q, Xing LY, Zhang HB, Zeng YS. Construction of a niche-specific spinal white matter-like tissue to promote directional axon regeneration and myelination for rat spinal cord injury repair. Bioactive Materials. 2021, 20;11:15-31. (CAS Q1, IF: 16.874, co-first and co-corresponding author)
- Bai YR, Lai BQ, Han WT, Sun JH, Li G, Ding Y, et al. Decellularized optic nerve functional scaffold transplant facilitates directional axon regeneration and remyelination in injured white matter of rat spinal cord. Neural Regeneration Research. 2021 Nov;16(11):2276-2283. (CAS Q2, IF: 6.058, co-first and co-corresponding author)
- Lai BQ, Che MT, Feng B, Bai YR, Ge Li, Ma YH, Wang LJ, Huang MY, Wang YQ, Jiang B, Ding Y, Zeng X, Zeng YS. Tissue-engineered neural network graft relays excitatory signal in the completely transected canine spinal cord. Advanced Science. 2019, DOI: 10.1002/advs.201901240. (CAS Q1, IF: 17.521)
- Lai BQ, Feng B, Che MT, Wang LJ, Cai S, Huang MY, Gu HY, Jiang B, Ling EA, Li M, Zeng X, Zeng YS. A Modular Assembly of Spinal Cord-Like Tissue Endows Targeted Tissue Repair in the Transected Spinal Cord. Advanced Science. 2018, doi:10.1002/advs.201800261 (CAS Q1, IF: 17.521)
- Lai BQ, Che MT, Du BL, Zeng Z, Ma YH, Feng B, Qiu XC, Zhang K, Liu S, Shen HY, Wu JL, Ling EA, Zeng YS. Transplantation of tissue engineering neural network and formation of neuronal relay into the transected rat spinal cord. Biomaterials. 2016, 109: 40-54. (CAS Q1, IF: 15.304)
- Lai BQ, Wang JM, Duan JJ, Chen YF, Gu HY, Ling EA, Wu JL, Zeng YS. The integration of NSC-derived and host neural networks after rat spinal cord transection. Biomaterials. 2013, 34(12):2888-2901. (CAS Q1, IF: 15.304)
Research Projects
- "Mechanism of rTMS in Regulating Corticospinal Tract Regeneration and Integration with Transplanted Neural Networks for Spinal Motor Pathway Remodeling"
National Natural Science Foundation of China (General Program, No. 82371400), 2024/01-2027/12, ¥470,000, ongoing, PI. - "Construction of Spinal Neural Tissue Based on Neural Stem Cells and Bioactive Materials and Its Mechanism in Neural Regeneration Regulation"
National Key R&D Program of China (Young Scientist Project, No. 2022YFA1105900), 2022/12-2027/11, ¥5,000,000, ongoing, PI. - "Mechanism of Novel Spinal Cord-Like Tissue Transplantation Combined with Caudal Nerve Electrical Stimulation in Repairing Motor Function After Complete Spinal Cord Transection"
National Natural Science Foundation of China (General Program, No. 81971157), 2020/01-2023/12, ¥550,000, ongoing, PI. - "Mechanism and Application of Tissue-Engineered Neuronal Relay Combined with Endogenous Stem Cell Activation in Spinal Cord Injury Repair"
Guangdong Natural Science Foundation for Distinguished Young Scholars (No. 2021B1515020045), 2021/1-2023/12, ¥1,000,000, PI. - "Youth Talent Lift Project"
China Association for Science and Technology (YESS, No. 2018QNRC001), 2018-2020, ¥450,000, PI. - "Mechanism of Neuronal Relay in Repairing Complete Spinal Cord Transection"
National Natural Science Foundation of China (Major Program, No. 81893100040), 2019/01-2023/12, ¥4,000,000, ongoing, Key Member (2nd). - "Stem Cell-Based Spinal Cord-Like Tissue Modules for Spinal Cord Injury Repair: Basic and Preclinical Research"
National Key R&D Program of China (Subproject, No. 2017YFA0104704), 2017/07-2021/12, ¥6,350,000, ongoing, PI. - "Construction of Spinal Cord-Like Tissue Based on Beagle Model and Its Preclinical Application in Spinal Cord Injury Repair"
Sun Yat-sen University Basic Research Fund for Young Teachers (No. 18ykpy38), 2018/1-2020/12, ¥150,000, ongoing, PI. - "Mechanism of Neural Stem Cells Combined with Tissue Engineering in Constructing Spinal Cord-Like Tissue for Spinal Cord Injury Repair"
National Natural Science Foundation of China (Youth Program, No. 81601062), 2016/09-2019/12, ¥170,000, completed, PI. - "Construction of Tissue-Engineered Spinal Cord-Like Tissue Using NSCs and Biomimetic Gelatin Scaffolds for Spinal Cord Injury Repair"
Guangzhou Science and Technology Program (No. 201707010434), 2017/05-2019/04, ¥200,000, completed, PI. - "Construction of Vascularized Spinal Cord-Like Tissue Using MSCs and NSCs for Spinal Cord Injury Repair"
China Postdoctoral Science Foundation (Special Grant, No. 2016T90816), 2016/6-2016/12, ¥150,000, completed, PI. - "Application of MSCs and NSCs Combined with Biomimetic Collagen Scaffolds in Constructing Vascularized Spinal Cord-Like Tissue for Spinal Cord Injury Repair"
Guangdong Science and Technology Development Fund (No. 2016A020214002), 2016/1-2019/03, ¥300,000, completed, PI. - "A Novel Strategy for Constructing and Transplanting Spinal Cord-Like Tissue to Repair Spinal Cord Injury"
China Postdoctoral Science Foundation (General Grant, No. 2015M582473), 2015/10-2016/12, ¥50,000, completed, PI.
Awards and Honors
His research has been published in top-tier journals such as Advanced Science, Biomaterials, and Bioactive Materials. He has led multiple national research projects, including three grants from the National Natural Science Foundation of China and two projects under the National Key R&D Program. He has also received the Guangdong Natural Science Foundation for Distinguished Young Scholars and the China Association for Science and Technology's Youth Talent Lift Project.
Academic Appointments
- Standing Committee Member, Youth Working Committee, Chinese Society for Anatomy
- Committee Member, Neural Regeneration and Repair Committee, Chinese Research Hospital Association