Personal Profile
Zhou Jiaguo, Professor in the Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Doctoral Supervisor, recipient of the National Science Fund for Distinguished Young Scholars, Distinguished Professor of the "Pearl River Scholars Program" in Guangdong Province, Outstanding Young Talent of the Ministry of Education in the New Century, and author of one of the Top 100 Excellent Doctoral Dissertations in China. He is currently a member of the Executive Committee of the Cardiovascular and Cerebrovascular Pharmacology Professional Committee of the Chinese Pharmacological Society, a member of the Executive Committee of the Renal Pharmacology Professional Committee of the Chinese Pharmacological Society, and Vice Chairman of the Cardiovascular Professional Committee of the Guangdong Pharmacological Society.

He graduated from the Department of Pharmacology at Sun Yat-sen University in 2004 with a Ph.D. degree. From January 2007 to May 2008, he conducted postdoctoral research in the United States. In September and December 2008, he was respectively appointed as a doctoral supervisor and professor at Sun Yat-sen University. In recent years, he has been dedicated to the research on new targets for the prevention and treatment of cardiovascular diseases. He has published more than 40 SCI-indexed papers in this field, especially a series of influential research papers on the relationship between chloride ions and the pathogenesis of cardiovascular diseases.

Academic Achievements
In recent years, he has focused on a series of studies on the role of chloride ion channels in major cardiovascular and cerebrovascular diseases. The main scientific findings include:
① Revealed that the decrease in intracellular Cl- concentration is an important mechanism for the occurrence and development of cardiovascular diseases.
② Clarified that ClC-3 and TMEM16A are the molecular bases of volume-regulatory chloride channels and calcium-activated chloride channels in the cardiovascular system, respectively. The activation of ClC-3 and TMEM16A chloride channels is the main mechanism for the decrease in intracellular Cl- concentration.
③ Identified that the functional abnormalities of ClC-3 chloride channels and TMEM16A chloride channels are new therapeutic targets for the prevention and treatment of cardiovascular and cerebrovascular diseases such as hypertension, vascular remodeling, and atherosclerosis.
④ Discovered that inhibiting ClC-3 chloride channels is an important way for statins to protect cardiovascular function through non-lipid-lowering effects, and clarified the therapeutic significance of developing ClC-3 volume-regulatory chloride channel blockers.

Academic Works and Textbooks

1. Mai XY, Shang JY, Liang SJ, Yu BX, Yuan JN, Lin Y, Zhang FR, Liu YY, Lv XF, Li CL, Wang WD, Zhou JG. Blockade of Orai1 Store-Operated Calcium Entry Protects Against Renal Fibrosis.  J Am Soc Nephrol  2016   (IF=9.34)
2. Liang SJ, Zeng DY, Mai XY, Shang JY, Wu QQ, Yuan JN, Yu BX, Zhou P, Zhang FR, Liu YY, Lv XF, Liu J, Ou JS, Qian JS, Zhou JG. Inhibition of Orai1 Store-operated Calcium Channel Prevents Foam Cell Formation and Atherosclerosis.  Arterioscler Thromb Vasc Biol.  2016;36(4):618-28   (IF=6.0)
3.Huang LY, He Q, Liang SJ, Su YX, Xiong LX, Wu QQ, Wu QY, Tao J, Wang JP, Tang YB, Lv XF, Liu J, Guan YY, Pang RP*, Zhou JG*. ClC-3 Chloride Channel/ antiporter Defect Contributes to Inflammatory Bowel Disease in Humans and Mice. Gut  2014;63:1587-1595    (IF=14.66)   
4. Wang M, Yang H, Zheng LY, Zhang Z, Tang YB, Wang GL, Du YH, Lv XF, Liu J, Zhou JG*, Guan YY*. Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension through promoting basilar smooth muscle cell proliferation. Circulation  2012;125(5):697-707.  (IF=15.072） 
5. Yang H, Huang LY, Zeng DY, Huang EW, Liang SJ, Tang YB, Su YX, Tao J, Shang F, Wu QQ, Xiong LX, Lv XF, Liu J, Guan YY, Zhou JG*. Decrease of intracellular chloride concentration promotes endothelial cell inflammation by activating nuclear factor-κB pathway. Hypertension 2012;60(5):1287-93   (IF=7.652)
6. Sun HX, Zeng DY, Li RT, Pang RP, Yang H, Hu YL, Zhang Q, Jiang Y, Huang LY, Tang YB, Yan GJ*, Zhou JG*. Essential role of microRNA-155 in regulating endothelium- dependent vasorelaxation by targeting endothelial nitric oxide synthase.  Hypertension   2012;60(6):1407-14.  (IF=7.652) 
7．Liu YJ, Wang XG, Tang YB, Chen JH, Lv XF, Zhou JG*, Guan YY*. Simvastatin ameliorates rat cerebrovascular remodeling during hypertension via inhibition of volume-regulated chloride channel.  Hypertension  2010;56(3):445-52  (IF=7.652)

Research Projects

1. ​Pharmacology of Cardio-cerebrovascular Drugs
   • ​Principal Investigator: Zhou Jiaguo
   • ​Participants:
   • ​Funding: 4,000,000 yuan
   • ​Year: 2015
2. ​The Role and Mechanism of Endophilin A2 Downregulation in Endothelial Dysfunction Caused by Metabolic Disorders
   • ​Principal Investigator: Zhou Jiaguo
   • ​Participants:
   • ​Funding: 1,000,000 yuan
   • ​Year: 2014
3. ​Study on the Role of Orai1 Calcium Channels in Atherosclerosis Formation and Its Mechanism
   • ​Principal Investigator: Zhou Jiaguo
   • ​Participants:
   • ​Funding: 500,000 yuan
   • ​Year: 2012
4. ​Study on the Mechanism of Bestrophin-3 Involved in Vascular Smooth Muscle Cell Proliferation and Vascular Remodeling
   • ​Principal Investigator: Zhou Jiaguo
   • ​Participants:
   • ​Funding: 120,000 yuan
   • ​Year: 2012
5. ​Study on the Role of Bestrophin 3 in Hypertensive Vascular Remodeling and Its Mechanism
   • ​Principal Investigator: Zhou Jiaguo
   • ​Participants:
   • ​Funding: 1,100,000 yuan
   • ​Year: 2012
6. ​Study on the Regulation of Endothelial Cell Inflammatory Response by ClC-3 Chloride Channels and Its Mechanism
   • ​Principal Investigator: Zhou Jiaguo
   • ​Participants:
   • ​Funding: 330,000 yuan
   • ​Year: 2009
7. ​Special Fund for the Excellent Talents of the New Century of the Ministry of Education
   • ​Principal Investigator: Zhou Jiaguo
   • ​Participants:
   • ​Funding: 500,000 yuan
   • ​Year: 2007
8. ​The Relationship between Statins in Preventing and Treating Hypertensive Cerebrovascular Remodeling and Chloride Channels
   • ​Principal Investigator: Zhou Jiaguo
   • ​Participants:
   • ​Funding: 260,000 yuan
   • ​Year: 2006
9. ​Study on the Effect of ClC-3 Chloride Channels on Atherosclerosis and Its Mechanism
   • ​Principal Investigator: Zhou Jiaguo
   • ​Participants:
   • ​Funding: 480,000 yuan
   • ​Year: 2007
10. ​Study on the Effect of ClC-3 Chloride Channels on Endothelial Cell Inflammatory Response and Its Mechanism
    • ​Principal Investigator: Zhou Jiaguo
    • ​Participants:
    • ​Funding: 50,000 yuan
    • ​Year: 2008
11. ​The Relationship between Statins in Preventing and Treating Cerebrovascular Remodeling and Chloride Channels
    • ​Principal Investigator: Zhou Jiaguo
    • ​Participants:
    • ​Funding: 20,000 yuan
    • ​Year: 2006

Awards and Honors
Awards

1. Guan Yongyuan, Zhou Jiaguo, Wang Guanlei, Tang Yongbo, Du Yanhua, Wang Xiaoguang, Ma Mingming, Lü Xiaofei, Liu Jie. Research on the Role and Mechanism of Cl- Channels in Cerebrovascular Remodeling.
   • ​Guangdong Provincial Science and Technology Progress Award: First Prize (2015)
2. Guan Yongyuan, Zhou Jiaguo, Wang Guanlei, Tang Yongbo, Du Yanhua, Wang Xiaoguang, Ma Mingming, Lü Xiaofei, Liu Jie. Research on the Role and Mechanism of Cl- Channels in Cerebrovascular Remodeling.
   • ​China Medical Science and Technology Award: Second Prize (2014)
3. Guan Yongyuan, Zhou Jiaguo, Wang Guanlei, Tang Yongbo, Du Yanhua, Wang Xiaoguang, Ma Mingming, Lü Xiaofei, Liu Jie. Research on the Role and Mechanism of Cl- Channels in Cerebrovascular Remodeling.
   • ​Second Prize of the Excellent Achievements in Scientific Research of Higher Education Institutions of the Ministry of Education: 2014
4. Guan Yongyuan, Wang Guanlei, Zhou Jiaguo, Xiao Guinan, Qiu Qinying, Ren Jingli, Qian Yan, Yi Quan, Wang Yandong, Zhang Haining, He Hua, Wei Wenli, Li Jinliang, Ruan Hongmei, Ding Yan, Chen Linxi, Wang Xuerong. Research on the Characteristics and Function of Chloride Channels in Vascular Smooth Muscle Cells.
   • ​Second Prize of the National Science and Technology Awards (Natural Science Awards) Nominated by the Ministry of Education: 2006

Honors

• ​2013: Distinguished Professor of the "Pearl River Scholars Program" in Guangdong Province
• ​2012: Provincial Training Object of the "Thousand, Hundred and Ten Talents Project" in Guangdong Higher Education Institutions
• ​2006: National Hundred Excellent Doctoral Dissertations Award
• ​2006: Selected into the "New Century Excellent Talents" Support Program of the Ministry of Education

Academic Affiliations

• Executive Committee Member of the Cardio-cerebrovascular Pharmacology Professional Committee of the Chinese Pharmacological Society
• Executive Committee Member of the Renal Pharmacology Professional Committee of the Chinese Pharmacological Society
• Committee Member of the Pharmaceutical Care Professional Committee of the Chinese Pharmacological Society
• Director of the Guangdong Pharmacological Society
• Vice Chairman of the Cardiovascular Pharmacology Professional Committee of Guangdong Province