Work Experience

January 2024 to present: Associate Professor, Sun Yat-sen Medical College, Sun Yat-sen University
August 2022 to January 2024: Distinguished Associate Researcher, Sun Yat-sen Medical College, Sun Yat-sen University
August 2020 to August 2022: Postdoctoral Fellow, Sun Yat-sen Medical College, Sun Yat-sen University
 

Educational Background

September 2015 to June 2020: PhD in Surgery, First Affiliated Hospital, Sun Yat-sen University
September 2010 to June 2015: Bachelor of Medicine, Sun Yat-sen Medical College, Sun Yat-sen University

Academic achievement

Academic paper

1. Luo P#, Chen X#, Gao F, Xiang AP, Deng C, Xia K*, Gao Y*. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Rescue Testicular Aging. Biomedicines. 2024.
2. Xia K#, Wang F#, Tan Z#, Zhang S#, Lai X, Ou W, Yang C, Chen H, Peng H, Luo P, Hu A, Tu X, Wang T, Ke Q, Deng C*, Xiang AP*. Precise correction of Lhcgr mutation in stem Leydig cells by prime editing rescues hereditary primary hypogonadism in mice. Advanced Science. 2023.
3. Xia K, Yu J, Liu G, Chen H, Ge R, Deng C. Editorial: Aging and male hypogonadism. Frontiers in Endocrinology. 2023.
4. Su Z#, Liu Z#, Lei W#, Xia K#, Xiao A, Hu Z, Zhou M, Zhu F, Tian J, Yang M, Wang D, Xiang AP, Nie J. Hyperhomocysteinemia lowers serum testosterone concentration via impairing testosterone production in Leydig cells. Cell Biology and Toxicology. 2023.
5. Xie Q#, Cao H#, Xia K#, Gao Y*, Deng C*. Prenatal DEHP Exposure Induces Premature Testicular Aging by Promoting Leydig Cell Senescence through the MAPK Signaling Pathways. Advanced Biology. 2023.
6. Xia K#, Wang F#, Lai X#, Dong L#, Luo P, Zhang S, Yang C, Chen H, Ma Y, Huang W, Ou W, Li Y, Feng X, Yang B, Liu C, Lei Z, Tu X, Ke Q, Mao FF, Deng C*, Xiang AP*. AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failure. Cell Reports Medicine. 2022.
7. Xie Q#, Luo P#, Xia K#, Li Z#, Xu Z*, Su C*, Deng C*. 46,XY disorders of sex development: the use of NGS for prevalent variants. Human Genetics. 2022.
8. Chen H#, Xia K#, Huang W#, Li H, Wang C, Ma Y, Chen J, Luo P, Zheng S, Wang J, Wang Y, Dong L, Tan Z, Lai X, Mao FF, Li W, Liang X, Wang T, Xiang AP, Qiong K*. Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates. Cell Discovery. 2021.
9. Feng X#, Xia K#, Ke Q#, Deng R, Zhuang J, Wan Z, Luo P, Wang F, Zang Z, Sun X, Xiang AP, Tu X*, Gao Y*, Deng C*. Transplantation of encapsulated human Leydig-like cells: A novel option for the treatment of testosterone deficiency. Molecular and Cellular Endocrinology. 2021.
10. Luo P#, Feng X#, Deng R#, Wang F, Zhang Y, Li X, Zhang M, Wan Z, Xiang AP, Xia K*, Gao Y*, Deng C*. An autofluorescence-based isolation of Leydig cells for testosterone deficiency treatment. Molecular and Cellular Endocrinology. 2021.
11. Xia K, Ma Y, Feng X, Deng R, Ke Q, Xiang AP*, Deng C*. Endosialin defines human stem Leydig cells with regenerative potential. Human Reproduction. 2020.
12. Xia K#, Chen H#, Wang J#, Feng X#, Gao Y, Wang Y, Deng R, Wu C, Luo P, Zhang M, Wang C, Zhang Y, Zhang Y, Liu G, Tu X, Sun X, Li W, Ke Q*, Deng C*, Xiang AP*. Restorative functions of autologous stem Leydig cell transplantation in a testosterone-deficient non-human primate model. Theranostics. 2020.

Scientific Research Projects Overview

1. National Natural Science Foundation Project: January 2024 to December 2027, RMB 490,000
2. National Natural Science Foundation Youth Project: January 2022 to December 2024, RMB 300,000
3. China Postdoctoral Science Foundation Project: October 2021 to July 2022, RMB 80,000
4. Guangdong Provincial Natural Science Foundation Project: January 2022 to December 2024, RMB 100,000
5. Guangzhou Basic and Applied Basic Research "Sailing" Program: January 2024 to December 2025, RMB 125,000
6. Sun Yat-sen University Basic Research Fund: January 2022 to December 2022, RMB 85,300