Personal profile

She is currently a member of the Youth Committee of Cell Therapy Branch of Guangdong Medical Association, a member of the Professional Committee of Integrated Reproductive Medicine of Guangdong Society of Traditional Chinese Medicine, and a researcher of the National and local Joint Engineering Research Center of Stem Cell and Regenerative Medicine, the Key Laboratory of Stem Cell and Tissue Engineering of the Ministry of Education, and the Key Laboratory of Reproductive Medicine of Guangdong Province. Key research achievements include: the use of gene editing technology to create primate models of a variety of human genetic diseases, including MCPH1 Cynomorphic monkey model of cerebellar gene deletion,FAH Gene deletion tyrosinemia type I cynomorphic monkey model and its study SHANK3
It was first confirmed that TALEN technique could be used to obtain a cynomolgus monkey model with significant phenotype. A variety of transgenic mouse and human normal and disease pluripotent stem cell lines were established. First confirmation CX43,CX45
It can promote the efficiency of cell reprogramming, and provide an important theoretical basis for improving the formation efficiency of iPSCs and exploring the mechanism of cell reprogramming. First author and corresponding author in Nature, Cell Research, Cell Discovery He has published many papers in other journals, presided over and participated in national key research and development projects, National Natural Science Foundation projects, provincial key areas research and development projects, and Guangzhou Health care collaborative innovation major projects.

Academic achievement

SCI papers have been published

1. Liang, C#., Ke, Q#., Liu, Z#., Ren, J#., Zhang, W#., Hu, J., Wang, Z., Chen, H., Xia, K., Lai, X., Wang, Q., Yang, K., Li, W., Wu, Z., Wang, C., Yan, H., Jiang, X., Ji, Z., Ma, M., Long, X., Wang, S., Wang, H., Sun, H., Belmonte, J., QU, J*., Xiang, A. P*. & Liu, G. H*. (2022), "BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence  in primates", Nucleic Acids Res, Vol. 50 No. 6, pp. 3323-3347.
2. Chen, H#., Xia, K#., Huang, W#., Li, H., Wang, C., Ma, Y., Chen, J., Luo, P., Zheng, S., Wang, J., Wang, Y., Dong, L., Tan, Z., Lai, X., Mao, F. F., Li, W., Liang, X., Wang, T., Xiang, A. P., & Ke, Q*. (2021). Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates. Cell Discovery, 7(1).
3. Xia, K#., Ma, Y., Feng, X#., Deng, R., Ke, Q*., Xiang, A.P*.& Deng, C.*. (2020). Endosialin defines human stem Leydig cells with regenerative potential. Human Reproduction, 35(10): 2197-2212.
4. Feng, X#., Xia, K#., Ke, Q#., Deng, R., Zhuang, J., Wan, Z., Luo, P., Wang, F., Zang, Z., Sun, X., Xiang, A.P., Tu, X*., Gao, Y., & Deng, C.* (2020). Transplantation of encapsulated human Leydig-like cells: A novel option for the treatment of testosterone deficiency. Molecular and Cellular Endocrinology, 519: 111039.
5. Xia, K#., Chen, H#. , Wang, J#., Feng, X#., Gao, Y., Wang, Y., Deng, R., Wu, C., Luo, P., Zhang, M., Wang, C., Zhang, Y., Zhang, Y., Liu, G., Tu, X., Sun, X., Li, W., Ke, Q*., Deng, C*. and Xiang, A.P*., (2020). Restorative functions of Autologous Stem Leydig Cell transplantation in a Testosterone-deficient non-human primate model. Theranostics, 10 (19):8705-8720. 
6. Sun, J#., Huang, Y#., Gong, J#., Wang, J., Fan, Y., Cai, J., Wang, Y., Qiu, Y., Wei, Y., Xiong, C., Chen, J., Wang, B., Ma, Y., Huang, L., Chen, X., Zheng, S., Huang, W., Ke, Q., Wang, T., Li, X., Zhang, W., Xiang, A. P*., & Li, W*. (2020). Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice. Nat Commun, 11(1): 5196.
7. Zhou, Y#., Sharma, J#., Ke, Q#., Landman, R#., Yuan, J., Chen, H., Hayden, D. S., Fisher, J. W., Jiang, M., Menegas, W., Aida, T., Yan, T., Zou, Y., Xu, D., Parmar, S., Hyman, J. B., Fanucci-Kiss, A., Meisner, O., Wang, D., Huang, Y., Li, Y., Bai, Y., Ji, W., Lai, X., Li, W., Huang, L., Lu, Z., Wang, L., Anteraper, S. A., Sur, M., Zhou, H*., Xiang, A. P*., Desimone, R., Feng, G*., & Yang, S*. (2019). Atypical behaviour and connectivity in SHANK3-mutant macaques. Nature, 570, 326-331.
8. Wang, H#., Li, D#., Zhai, Z#., Zhang, X., Huang, W., Chen, X., Huang, L., Liu, H., Sun, J., Zou, Z., Fan, Y., Ke, Q., Lai, X., Wang, T., Li, X., Shen, H., Xiang, A. P. *, & Li, W*. (2019). Characterization and Therapeutic Application of Mesenchymal Stem Cells with Neuromesodermal Origin from Human Pluripotent Stem Cells. Theranostics, 9(6): 1683-1697.
9. Li, W#., Huang, L#., Zeng, J#., Lin, W., Li, K., Sun, J., Huang, W., Chen, J., Wang, G., Ke, Q., Duan, J., Lai, X., Chen, R., Liu, M., Liu, Y., Wang, T., Yang, X., Chen, Y., Xia, H*., & Xiang, A. P*. (2018). Characterization and transplantation of enteric neural crest cells from human induced pluripotent stem cells. Mol Psychiatry, 23, 499-508.
10. Shi, L#., Huang, L#., He, R#., Huang, W., Wang, H., Lai, X., Zou, Z., Sun, J., Ke, Q., Zheng, M., Lu, X., Pei, Z., Su, H., Xiang, A. P., Li, W*., & Yao, X*. (2018). Modeling the Pathogenesis of Charcot-Marie-Tooth Disease Type 1A Using Patient-Specific iPSCs. Stem Cell Reports, 10, 120-133.
11. Wang, J#., Huang, Y#., Cai, J#., Ke, Q., Xiao, J., Huang, W., Li, H., Qiu, Y., Wang, Y., Zhang, B., Wu, H., Zhang, Y., Sui, X., Bardeesi, A. S. A., & Xiang, A. P*. (2018). A Nestin-Cyclin-Dependent Kinase 5-Dynamin-Related Protein 1 Axis Regulates Neural Stem/Progenitor Cell Stemness via a Metabolic Shift. Stem Cells, 36, 589-601.
12. Wang, J#., Liu, X#., Qiu, Y#., Shi, Y., Cai, J., Wang, B., Wei, X., Ke, Q., Sui, X., Wang, Y., Huang, Y., Li, H., Wang, T., Lin, R., Liu, Q., & Xiang, A. P*. (2018). Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells. Journal of Hematology & Oncology, 11.
13. Zhang, Y#., Wang, J#., Huang, W#., Cai, J., Ba, J., Wang, Y., Ke, Q., Huang, Y., Liu, X., Qiu, Y., Lu, Q., Sui, X., Shi, Y., Wang, T., Shen, H., Guan, Y., Zhou, Y., Chen, Y., Wang, M., & Xiang, A. P*. (2018). Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation. Nat Commun, 9, 3613.
14. Ke, Q#., Li, L#., Yao, X#., Lai, X., Cai, B., Chen, H., Chen, R., Zhai, Z., Huang, L., Li, K., Hu, A., Mao, F. F., Xiang, A. P., Tao, L*., & Li, W*. (2017). Enhanced generation of human induced pluripotent stem cells by ectopic expression of Connexin 45. Scientific Reports, 7, 458.
15. Zhang, C#., Liao, W., Cai, B., Liu, F., Ke, Q., Zhu, X., He, X., & Hu, A*. (2017). The similarities between smDCs and regDCs in alleviating the immune injury caused by transplantation of hepatocytes differentiated from ESCs. Stem Cell Research & Therapy, 8, 266.
16. Wang, J#., Cai, J#., Huang, Y#., Ke, Q., Wu, B., Wang, S., Han, X., Wang, T., Wang, Y., Li, W., Lao, C., Song, W*., & Xiang, A. P*. (2016). Nestin regulates proliferation and invasion of gastrointestinal stromal tumor cells by altering mitochondrial dynamics. Oncogene, 35, 3139-3150. 
17. Ma, Y#., Li, J#., Wang, G#., Ke, Q#., Qiu, S., Gao, L., Wan, H., Zhou, Y., Xiang, A. P., Huang, Q., Feng, G*., Zhou, Q*., & Yang, S*. (2016). Efficient production of cynomolgus monkeys with a toolbox of enhanced assisted reproductive technologies. Scientific Reports, 6, 25888.
18. Ke, Q#., Li, W#., Lai, X#., Chen, H., Huang, L., Kang, Z., Li, K., Ren, J., Lin, X., Zheng, H., Huang, W., Ma, Y., Xu, D., Chen, Z., Song, X., Lin, X., Zhuang, M., Wang, T., Zhuang, F., Xi, J., Mao, F. F., Xia, H., Lahn, B. T., Zhou, Q*., Yang, S*., & Xiang, A. P*. (2016). TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Cell Research, 26, 1048-1061.
19. Li, W#., Huang, L#., Lin, W#., Ke, Q., Chen, R., Lai, X., Wang, X., Zhang, J., Jiang, M., Huang, W., Wang, T., Yang, X., Chen, Y., Song, W*., & Xiang, A. P*. (2015). Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells. Biomaterials, 39, 75-84. 
20. Ke, Q#., Li, L#., Cai, B#., Liu, C., Yang, Y., Gao, Y., Huang, W., Yuan, X., Wang, T., Zhang, Q., Harris, A. L., Tao, L., & Xiang, A. P*. (2013). Connexin 43 is involved in the generation of human-induced pluripotent stem cells. Human Molecular Genetics, 22, 2221-2233. 
21. Cheng, F#., Ke, Q#., Chen, F#., Cai, B., Gao, Y., Ye, C., Wang, D., Zhang, L., Lahn, B. T., Li, W*., & Xiang, A. P*. (2012). Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials, 33, 3195-3204. 

Scientific research project

1. National Natural Science Foundation of China Project 82171617 (2022.01-2025.12) Project Leader (1/9) 530,000 Title: Research on the directional differentiation of pluripotent stem cells into follicular membrane cells and its mechanism
2. Guangdong Key Areas Research and Development Plan Project 2019B020235002 (2019.01-2021.12) Project leader 3 million Title: Evaluation of the efficacy of transplantation of mesenchymal stem cells derived from pluripotent stem cells in primates
3. National Key Research and Development Plan Project 2018YFA0801404 (2019.11-2024.10) Project core 300.38/70.5 million Title: Research on gene editing to create monkey models of metabolic diseases and brain cognitive development diseases and their pathogenic mechanisms
4. National Key Research and Development Plan Project 2018YFA0107200 (2018.07-2023.12) Project backbone 3 million / 29.32 million title: Functional identification, isolation and preparation of mesenchymal stem cell subsets and efficacy evaluation
5. Guangdong Provincial Science and Technology Plan Major project 2017B020231001 (2017.09-2020.08) Project backbone topic: Large animal model of stem cell therapy and the construction of animal chimeric technology platform based on stem cells 1 million /10 million
6. Sun Yat-sen University Major Project Cultivation and Emerging, interdisciplinary funding program project 15ykjc01c (2015.10-2017.10) Project leader 150,000 Title: Construction of MCPH1 gene knockout cynophilic monkey model and the role of this gene on neural differentiation
7. Guangdong Provincial Science and Technology Program Major Project 2014B020225007 (2015.01-2017.12) Participant 1.25 million /5 million Title: Research on stem cell therapy of gene knockout disease model of cyborg monkey
8. National Natural Youth Science Foundation Project 31301219 (2014.01-2016.12) Project leader 210,000 Title: Study on the mechanism of CX43 affecting induced pluripotent stem cell formation
9. Doctoral Foundation Project of the Ministry of Education 20130171120061 (2014.01-2016.12) Project Leader 40,000 Title: Effect of gap connexin on the formation of induced pluripotent stem cells and related mechanisms