Personal profile

Huang Lianyan, Doctor, professor, doctoral supervisor, Sun Yat-sen University introduced talents.
Dr. Huang Liyan graduated from the former First Military Medical University, majoring in clinical medicine. Later, he received his master's degree and doctor's degree in cell biology from Professor Zou Fei, a famous scholar of public health in China. From 2012 to 2017, he completed his postdoctoral training in the laboratory of Professors Guang Yang and Wenbiao Gan, New York University, USA, which is an international leader in the field of volume two-photon imaging.
Professor Huang Lianyan has been engaged in research on nervous system function for a long time, and his research results have been published in Science Translational Medicine, Nature Neuroscience, Molecular Psychiatry and other journals. The research results were selected as a cover article by Science Translational Medicine, and the journal Nature wrote a review article for his work (Nature 2016, 536:36); The findings were used in the FDA's Clinical Medication Guidelines (FDA Drug Safety Communication 2017).

Research direction

1)Neural circuit mechanism and treatment of cognitive dysfunction: To explore the cognitive dysfunction caused by anesthesia, aging and abnormal development, and reveal its neural circuit mechanism and treatment methods.
2)The neural mechanism of the interaction between sensory perception and emotion: To study the changes and functions of cortical neurons and glial cells in the process of chronic pain, to explore the encoding and integration of neuronal dendrites on chronic pain information, and to analyze the regulation of different types of neurons, astrocytes, microglia and their transmitters on chronic pain. The long-term goal of this direction is to reveal the neural coding rules and molecular targets of chronic pain, and to help chronic pain patients reduce symptoms by regulating neural coding in vivo.
3)The role of neuroinflammation in neurological diseases
Using neurodegenerative diseases and autoimmune diseases as models, to study the role of neuroinflammation in the occurrence and development of diseases, and to explore its cellular and molecular mechanisms. The long-term goal of this direction is to reveal the role and mechanism of neuroinflammation in the occurrence and development of nervous system diseases, and to find ways to treat diseases by regulating inflammation.
Our laboratory long-term recruiting full-time researchers (distinguished is/deputy researcher, postdoctoral), doctor and master graduate student, links to /article/8091

Academic achievement

Representative paper

1. Lianyan Huang, Joseph Cichon, Ipe Ninan, Guang Yang. Post-anesthesia potentiation of AMPA receptor activity prevents anesthesia-induced learning and synaptic deficits. Science Translational Medicine 2016 22;8(344):344ra85. (Cover Story, Comment in Nature News & Views)
2. Lianyan Huang*, Jianhua Jin, Kai Chen, Sikun You, Hongyang Zhang, Alexandra Sideris, Monica Norcini, Esperanza Recio-Pinto, Jing Wang, Wen-Biao Gan, Guang Yang*. Cerebral microglial BDNF promotes peripheral nerve injury-induced cortical plasticity and pain hypersensitivity. Plos Biology. In press (*Corresponding author)）
3. Zongyi Zhan, Yali Wu, Zitian Liu, Yadan Quan, Deling Li, Yiru Huang, Shana Yang, Kaili Wu, Lianyan Huang*, Minbin Yu*. Reduced Dendritic Spines in the Visual Cortex Contralateral to the Optic Nerve Crush Eye in Adult Mice. Invest Ophthalmol Vis Sci. 2020 Aug 3;61(10):55. 1（*Corresponding author)）
4. Lianyan Huang*, Hang Zhou, Kai Chen, Xiao Chen, Guang Yang*. Learning-Dependent Dendritic Spine Plasticity Is Reduced in the Aged Mouse Cortex. Front Neural Circuits. 2020 Nov 26;14:581435. （*Corresponding author)）
5. Lianyan Huang, Guang Yang. Repeated Exposure to Ketamine–Xylazine during Early Development Impairs Motor Learning–dependent Dendritic Spine Plasticity in Adulthood. Anesthesiology 2015 122(4):821-31
6. Lianyan Huang#, Boxing Li#, Shihao Tang, Hongbo Guo, Wenjun Li, Xiaozhou Huang, Wenjuan Yan, Fei Zou. Mitochondrial KATP Channels Control Glioma Radioresistance by Regulating ROS-Induced ERK Activation. Molecular Neurobiology 2015 52(1):626-37.
7. Lianyan Huang#, Boxing Li#, Wenjun Li, Hongbo Guo, Fei Zou. ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity. Carcinogenesis 2009, 30(5):737–744.
8. Lianyan Huang, Juan J Lafaille, Guang Yang. Learning-Dependent Dendritic Spine Plasticity Is Impaired in Spontaneous Autoimmune Encephalomyelitis. Dev Neurobiol. 2021 May 4. doi: 10.1002/dneu.22827. Online ahead of print.
9. Boxing Li, Wei Jie, Lianyan Huang, Peng Wei, Shuji Li, Zhengyi Luo, Allyson K. Friedman, Andrea L. Meredith, Ming-Hu Han, Xin-Hong Zhu, Tian-Ming Gao. Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling. Nature Neuroscience 2014, 17: 1055–1063
10. Bin Wang, Yu Liu, Lianyan Huang, Jianjun Chen, Jing jing Li, Ruishan Wang, Eunhee Kim, Carles Justicia, Kazuko Sakata, Hao Chen, Anna Planas, Rennolds Ostrom, Wei Li, Guang Yang, Michael McDonald, Ruihong Chen, Detlef Heck, Francesca-Fang Liao. A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism. Molecular Psychiatry 2017 Jul;22(7):990-1001