Personal profile

Professor of Medical Microbiology, doctoral supervisor, Member of Chinese Society of Microbiology. In 2002, he began to teach in Zhongshan School of Medicine, Sun Yat-sen University (Center for Molecular Medicine, Department of Microbiology). He teaches medical microbiology at various levels in various specialties such as college and graduate students.
He received his doctorate in 2009. He has conducted postdoctoral research at the University of Chicago (2011, herpes oncolytic virus) and Mayo Clinic (2016, measles oncolytic virus). Since his doctoral degree (2004-2009), he has independently initiated the research of alphavirus M1 related oncolytic virology in China, and has been committed to the research of related virology, immunology, oncology and pharmacology for a long time. He has presided over a number of scientific research projects such as National Natural Science Foundation (3), Guangdong Provincial Science and Technology Plan key project (1), Guangdong Provincial Natural Science Foundation, and the Doctoral Foundation of the Ministry of Education, with a total of more than 3 million yuan.
It was first revealed that alphavirus M1 can specifically target tumor tissue to kill without destroying the biological characteristics of normal tissues, and established alphavirus M1 as a new oncolytic virus originating from China. Further, a series of experimental studies were carried out on the effectiveness and safety of its development as an oncolytic virus, as well as the molecular mechanism of tumor targeting mechanism and cell killing mechanism, which initially revealed the anticancer mechanism of oncolytic virus M1, laying a foundation for its clinical development. In addition, the potential co-drugs such as synergists and sensitizers of M1 oncolytic virus were screened, identified and the related pharmacological mechanisms were studied.
So far, he has published more than 20 SCI scientific research papers, of which 11 SCI scientific research papers have been published as the first author or corresponding author. Including 4 papers published in the first division of JCR of Chinese Academy of Sciences in Science Translational Medicine (IF= 17.1), PNAS (IF= 10.4), neuro-oncology(IF=7.1), Molecular Therapy (IF= 6.8), The second district of the Chinese Academy of Sciences has 5 articles in Human Gene Therapy, Urol Oncol-Semin Ori., J Neurosurg Anesthesiol., Oncotarget, Cell Cycle, etc. M1 oncolytic virus related invention patents totaled 33, covering 54 countries and regions.

Academic achievement

Published papers in recent years († first author, * Corresponding author)
 

1. Zhang H†, Li K† , Lin Y†, Xing F, Xiao X, Cai J, Zhu W, Liang J, Tan Y, Fu L, Wang F, Yin W, Lu B, Qiu P, Su X, Gong S, Bai X, Hu J*, Yan G*. Targeting VCP enhances anti-cancer activity of oncolytic virus M1 in hepatocellular carcinoma,Science Translational Medicine,2017;23(9) 404. pii: eaam7996 （Medical Division 1, IF=17.1）
2. Li K†, Zhang H†, Qiu J, Lin Y, Liang J, Xiao X, Fu L, Wang F, Cai J, Tan Y, Zhu W, Yin W, Lu B, Xing F, Tang L, Yan M, Mai J, Li Y, Chen W, Qiu P, Su X, Gao G, Tai PW, Hu J*, Yan G*. Activation of cyclic adenosine monophosphate pathway increases the sensitivity of cancer cells to the oncolytic virus M1. Mol Ther. 2016;24(1):156-165. (Medical Division 1，IF=6.8）
3. Zhang H†, Lin Y†, Li K, Liang J, Xiao X, Cai J, Tan Y, Xing F, Mai J, Li Y, Chen W, Sheng L, Gu J, Zhu W, Yin W, Qiu P, Su X, Lu B, Tian X, Liu J, Lu W, Dou Y, Huang Y, Hu B, Kang Z, Gao G, Mao Z, Cheng S, Lu L, Bai X, Gong S, Yan G, Hu J*. Naturally existing oncolytic virus M1 is nonpathogenic for the nonhuman primates after multiple rounds of repeated intravenous injections. Hum Gene Ther. 2016; 27(9):700-711.(Medical Division 2，IF=3.6)
4. Li K†, Liang J†, Lin Y†, Zhang H, Xiao X, Tan Y, Cai J, Zhu W, Xing F, Hu J*, Yan G*.A classical PKA inhibitor increases the oncolytic effect of M1 virus via activation of exchange protein directly activated by cAMP 1. Oncotarget.  2016; 26;7(30):48443-48455. (Medical Division 2，IF=5.3)
5. Zhou Y†, Wu S†, Liang C†, Lin Y, Zou Y, Li K, Lu B, Shu M, Huang Y, Zhu W, Kang Z, Xu D*, Hu J*, Yan G*. Transcriptional upregulation of microtubule-associated protein 2 is involved in the protein kinase A-induced decrease in the invasiveness of glioma cells. Neuro Oncol. 2015, 17(12):1578-1588. (Medical Division 1，IF=7.1）
6. Lin Y†, Zhang H†, Liang J†, Li K, Zhu W, Fu L, Wang F, Zheng X, Shi H, Wu S, Xiao X, Chen L, Tang L, Yan M, Yang X, Tan Y, Qiu P, Huang Y, Yin W, Su X, Hu H, Hu J*, Yan G*. Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4504-12.  (General Class Area 1，IF=10.4）
7. Ou Y†, Zheng X†, Gao Y†, Shu M, Leng T, Li Y, Yin W, Zhu W, Huang Y, Zhou Y, Tang J, Qiu P, Yan G, Hu J*, Ruan H*, Hu H*. Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics. Urol Oncol-Semin Ori. 2014 Jan;32(1):47.e21-8.  (Urology and Nephrology Area 2，IF=3.0）
8. Zheng X†, Ou Y†, Shu M, Wang Y, Zhou Y, Su X, Zhu W, Yin W, Li S, Qiu P, Yan G, Zhang J*, Hu J*, Xu D*.Cholera toxin, a typical protein kinase A activator, induces G1 phase growth arrest in human bladder transitional cell carcinoma cells via inhibiting the c-Raf/MEK/ERK signaling pathway. Mol Med Rep. 2014 May;9(5):1773-9. (Medical Division 4，IF=1.7）
9. Chen J†, Ouyang Y†, Cao L, Zhu W, Zhou Y, Zhou Y, Zhang H, Yang X, Lin J*, Hu J*, Yan G. Diazepam inhibits proliferation of human glioblastoma cells through triggering a G0/G1 cell cycle arrest. J Neurosurg Anesthesiol. 2013, 25(3):285-291. (Department of Surgery 2，IF=2.9）
10. Zhang H†, Zhu W†, Su X, Wu S, Lin Y, Li J, Wang Y, Chen J, Zhou Y, Qiu P, Yan G, Zhao S, Hu J*, Zhang J*. Triptolide inhibits proliferation and invasion of malignant glioma cells. J Neurooncol. 2012，109(1):53-62 （Medical Region 3，IF=3.0）
11. Hu J†, Cai XF†, Yan G*. Alphavirus M1 induces apoptosis of malignant glioma cells via downregulation and nucleolar translocation of p21(WAF1/CIP1) protein. Cell Cycle, 2009，8(20):3328-3339. (Biology Zone 2，IF=4.0)

Textbook monograph

Participate in compiling textbooks
Participated in editing Medical Microbiology (Editor Li Fan, icourse Course: Basic Medical Series of Colleges and Universities), Higher Education Press, 2014
Participated in editing Medical Microbiology (Chief editor Qi Zhongtian, National Medical Electronic Bag), People's Military Medical Publishing House, 2015
Participated in the compilation of Introduction to Medical Examination (Feng Shuying et al., Planning Textbooks for National Medical Colleges and Universities, Science Press, 2016

Scientific research project

Presiding over scientific research projects:
National Natural Science Foundation of China, The synergistic effect and mechanism of cell-cellar-dependent macrophage repolarization and oncolytic virus immunity (81773751), 2018.1-2021.12, Hu Jun, 615,000
Project of National Natural Science Foundation of China, Study on the intracellular mechanism of natural oncolytic virus M1 targeting to kill malignant glioma cells (81273531), 2013.1-2016.12, Jun Hu, 600,000
Project of National Natural Science Foundation of China (Surface), Synergistic mechanism and clinical significance of PKA activator on natural oncolytic virus M1 (81573447), 2016.1-2019.12, Hu Jun, 720,000
Science and Technology Program Project of Guangdong Province (Social Development field), Safety study of intravenous administration of novel oncolytic virus M1 in non-human primates (2015B020211003), 2016.1-2019.12, Jun Hu, 1 million
Natural Science Foundation of Guangdong Province (Free application), Study on the mechanism of protein kinase A activator's synergistic effect on oncolytic virus M1 (2015A030313081), 2016.1-2017.12, Hu Jun, 100,000
Special Research Fund for Doctoral Programs of Higher Education Institutions of the Ministry of Education, Dual-targeted cycle regulation of miR-690 (20100171120052), 2011.1-2013.12, Hu Jun, 36,000