Personal profile

Winner of the National Outstanding Youth Fund; National overseas high-level young talents; Leader of innovation and entrepreneurship team of Guangdong Pearl River Talent Plan.
He graduated from Beijing Normal University in June 2002 with a Bachelor of Science degree. He then graduated from Peking Union Medical College in June 2005 with a Master's degree in Medicine. In June 2009, he graduated from Beijing Institute of Life Sciences with a Doctor of Science degree. He began postdoctoral research at the Icahn School of Medicine at Mount Sinai, NY, U.S.A. in September 2009 until the end of 2015. His research work mainly focuses on hot biomedical fields such as embryonic stem cells, somatic cell reprogramming, and epigenetic regulatory mechanisms of early embryonic development. In recent years, he has published 30 SCI papers (8 IF> 20,20 IF>10). among
He published 15 papers (6 IF>20, 9 IF>10) in correspondence or one book (including co-authors), including Nature, Cell Stem Cell (2 papers), Cell Research (2 papers), Nature Structural & Molecular Biology, etc.
Ding Junjun Laboratory website:/stemcellding/
Supervisor:Doctoral supervisor
Subject Major:Stem cell
Educational background:
1998-2002.
B.S. in Biological Sciences, Beijing Normal University
2002-2005.
Master of Pathogenic Biology, Union Medical College, China
2006-2009.
PhD, Cell Biology, Beijing Institute of Life Sciences
Work Experience:
2005-2006.
Beijing Institute of Life Sciences,
Stem Cell Biology, Research Assistant,
2009-2015.
Mount Sinai School of Medicine
Stem Cell Biology, Postdoc,
2016- Now
Sun Yat-sen Medical College, Sun Yat-sen University
Stem Cell Biology, Professor/Doctoral Supervisor

Research field

By deeply studying the pluripotency of stem cells and the molecular mechanism of somatic cell reprogramming, this research group elucidates the self-renewal of embryonic stem cells and the occurrence and development process of somatic cell reprogramming, and establishes tumor disease models by using iPS cells, which is of great significance for the basic research and clinical application of stem cells. Based on this, the laboratory is carrying out the following research around pluripotent stem cells:
1.Epigenetic and phase separation:
The epigenetic regulatory mechanisms of pluripotent stem cells, somatic cell reprogramming and early embryonic development, including the regulatory mechanisms and functions of phase separation, were investigated by means of gene editing and proteomics.
2.3D genome:
The 3D genome regulation mechanism of stem cell pluripotency was studied by using 3D chromosome structure techniques (HiC, HiChIP, etc.).
3.Bioinformatics and Machine Learning:
Using bioinformatics technology to conduct epigenomics research, integrating 2D genomics, transcriptomics, proteomics and other data with 3D chromatin data such as HiC and HiChIP to study cell fate and disease occurrence;
4.Stem cell disease model:
Using induced pluripotent stem cells (iPS cells) to establish human disease models, especially breast cancer models, and use models to study their pathogenesis, early diagnosis, and the long-term goal is to screen drugs.

Academic achievement

Newsletters and first author papers (including co-authored ones) :
Representative communications and first-author papers (including co-authored ones) :

1. Xiuxiao Tang*, Pengguihang Zeng*, Kezhi Liu, Li Qing, Yifei Sun, Xinyi Liu, Lizi Lu, Chao Wei, Jia Wang, Shaoshuai Jiang, Jun Sun, Wakam Chang, Haopeng Yu, Hebing Chen, Jiaguo Zhou, Chengfang Xu#, Lili Fan#, Yi-Liang Miao#, Junjun Ding# (Corresponding author). The PTM profiling of CTCF reveals the regulation of 3D chromatin structure by O-GlcNAcylation. Nature Communications. 2024 Apr 1;15(1):2813. doi: 10.1038/s41467-024-47048-3. (IF:16.6)
2. Jun Sun*, Jiale Qu*, Cai Zhao*, Xinyao Zhang, Xinyu Liu, Jia Wang, Chao Wei, Xinyi Liu, Mulan Wang, Pengguihang Zeng, Xiuxiao Tang, Xiaoru Ling, Li Qing, Shaoshuai Jiang, Jiahao Chen, Tara SR Chen, Yalan Kuang, Jinhang Gao, Xiaoxi Zeng, Dongfeng Huang, Yong Yuan#, Lili Fan#, Haopeng Yu#, Junjun Ding# (Corresponding author). Precise prediction of phase-separation key residues by machine learning. Nature Communications. 2024 Mar 26;15(1):2662. doi: 10.1038/s41467-024-46901-9. (IF:16.6)
3. Jiale Qu*, Jun Sun*, Cai Zhao, Xinyi Liu, Xinyao Zhang, Shaoshuai Jiang, Chao Wei, Haopeng Yu, Xiaoxi Zeng#, Lili Fan#, Junjun Ding# (Corresponding author). Simultaneous profiling of chromatin architecture and transcription in single cells. Nature Structural & Molecular Biology. 2023 Sep;30(9):1393-1402. doi: 10.1038/s41594-023-01066-9.(IF:18.36)
4. Chao Wei*, Lumeng Jia*, Xiaona Huang*, Jin Tan*, Mulan Wang, Jing Niu, Yingping Hou, Jun Sun, Pengguihang Zeng, Jia Wang, Li Qing, Lin Ma, Xinyi Liu, Xiuxiao Tang, Fenjie Li, Shaoshuai Jiang, Jingxin Liu, Tingting Li, Lili Fan, Yujie Sun, Juntao Gao, Cheng Li, Junjun Ding# (Corresponding author). CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation. Cell Research. 2022 Aug;32(8):744-760. doi: 10.1038/s41422-022-00676-0. (IF:46.297)
5. Xinyi Liu*, Shaoshuai Jiang*, Lin Ma, Jiale Qu, Longying Zhao, Xing Zhu, Junjun Ding# (Corresponding author). Time-dependent effect of 1,6-hexanediol on biomolecular condensates and 3D chromatin organization. Genome Biology. 2021 Aug 17;22(1):230. doi: 10.1186/s13059-021-02455-3. (IF: 17.906)
6. Jia Wang, Haopeng Yu, Qian Ma, Pengguihang Zeng, Danya Wu, Yingping Hou, Xinyi Liu, Lumeng Jia, Jun Sun, Yilong Chen, Diana Guallar, Miguel Fidalgo, Jiahao Chen, Yangyinhui Yu, Shaoshuai Jiang, Fenjie Li, Cai Zhao, Xianglin Huang, Jianlong Wang, Cheng Li, Yujie Sun, Xiaoxi Zeng, Wei Zhang, Yiliang Miao, Junjun Ding# (Corresponding author). Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions. Cell Stem Cell. 2021 May 25; doi:https://doi.org/10.1016/j.stem.2021.04.023. （IF: 25.269）
7. Xiaona Huang* Chao Wei* Fenjie Li* Lumeng Jia, Pengguihang Zeng, Jiahe Li, Jin Tan, Tuanfeng Sun, Shaoshuai Jiang, Jia Wang, Xiuxiao Tang, Qingquan Zhao, Bin Liu, Limin Rong, Cheng Li, and Junjun Ding# (Corresponding author). PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions. Protein & Cell. 2019 Oct;10(10):709-725. （IF: 15.328）
8. Li Fenjie, Junjun Ding# (Corresponding author).  Sialylation is involved in cell fate decision during development, reprogramming and cancer progression. Protein & Cell. 2019 Aug;10(8):550-565. Review. （IF: 15.328）
9. Jia Wang*, Xingui Wu*, Chao Wei*, Xin Huang, Qian Ma, Xiaona Huang, Francesco Faiola, Diana Guallar, Miguel Fidalgo, Tingyuan Huang, Di Peng, Li Chen, Haopeng Yu, Xingyu Li, Junyi Sun, Xinyi Liu, Xiaoxia Cai, Xiao Chen, Ling Wang, Jian Ren, Jianlong Wang#, Junjun Ding# (Corresponding author). YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells, Stem Cell Reports. 2018 March 1; doi: 10.1016/j.stemcr.2018.02.004. （IF: 7.294）
10. Junjun Ding, Xin Huang, Ningyi Shao, Hongwei Zhou, Dung-Fang Lee, Francesco Faiola, Miguel Fidalgo, Diana Guallar, Arven Saunders, Pavel V. Shliaha, Hailong Wang, Avinash Waghray, Dmitri Papatsenko, Carlos Sánchez-Priego, Dan Li, Ye Yuan, Ihor R. Lemischka, Li Shen, Kevin Kelley, Haiteng Deng, Xiaohua Shen, and Jianlong Wang. Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming, Cell Stem Cell. 2015 Jun 4;16(6):653-68.（IF: 25.269）
11. Yael Costa*, Junjun Ding* (co-first author), Thorold W. Theunissen*, Francesco Faiola*, Timothy A. Hore, Pavel V. Shliaha, Miguel Fidalgo, Arven Saunders, Moyra Lawrence, Sabine Dietmann, Satyabrata Das, Dana N. Levasseur, Zhe Li, Mingjiang Xu, Wolf Reik, Jose´ C. R. Silva & Jianlong Wang.  NANOG-dependent function of TET1 and TET2 in establishment of pluripotency, Nature. 2013 Mar 21;495(7441):370-4.（IF: 69.504）
12. Junjun Ding, Huilei Xu, Francesco Faiola, Avi Ma'ayan, Jianlong Wang. Oct4 links multiple epigenetic pathways to the pluripotency network, Cell Research. 2012 Jan;22(1):155-67（IF: 46.297）
13. Junjun Ding*, Yuanbiao Guo*, Sheng Liu, Yujuan Yan, Gang Chang, Zhaohui Kou, Yu Zhang, Ying Jiang, Fuchu He, Shaorong Gao and Jianli Sang. ES Cells Derived from Somatic Cloned and Fertilized Blastocysts are Post- transcriptionally Indistinguishable: a MicroRNA and Protein Profiles Comparison, Proteomics. 2009 May; 9(10):2711-21.（IF: 5.393）

Excerpts from other papers

1. Guang Shi, Yaofu Bai, Xiya Zhang, Junfeng Su, Junjie Pang, Quanyuan He, Pengguihang Zeng, Junjun Ding, Yuanyan Xiong, Jingran Zhang, Jingwen Wang, Dan Liu, Wenbin Ma, Junjiu Huang, Zhou Songyang. Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation. Protein & Cell. 2022 Oct;13(10):721-741. doi: 10.1007/s13238-021-00884-1. (IF:15.328)
2. Mingsen Li, Huaxing Huang, Bofeng Wang, Shaoshuai Jiang, Huizhen Guo, Liqiong Zhu, Siqi Wu, Jiafeng Liu, Li Wang, Xihong Lan, Wang Zhang, Jin Zhu, Fuxi Li, Jieying Tan, Zhen Mao, Chunqiao Liu, Jianping Ji, Junjun Ding, Kang Zhang, Jin Yuan, Yizhi Liu, Hong Ouyang. Comprehensive 3D epigenomic maps define limbal stem/progenitor cell function and identity. Nature Communications. 2022 Mar 11;13(1):1293. doi: 10.1038/s41467-022-28966-6. (IF:17.694)
3. Xin Huang, Kyoung-Mi Park, Paul Gontarz, Bo Zhang, Joshua Pan, Zachary McKenzie, Laura A Fischer, Chen Dong, Sabine Dietmann, Xiaoyun Xing, Pavel V Shliaha, Jihong Yang, Dan Li, Junjun Ding, Tenzin Lungjangwa, Maya Mitalipova, Shafqat A Khan, Sumeth Imsoonthornruksa, Nick Jensen, Ting Wang, Cigall Kadoch, Rudolf Jaenisch, Jianlong Wang, Thorold W Theunissen. OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human. Nature Communications. 2021 Aug 26;12(1):5123. doi: 10.1038/s41467-021-25107-3. (IF:17.694)
4. Xiang Sun, Zhijun Ren, Yixian Cun, Cai Zhao, Xianglin Huang, Jiajian Zhou, Rong Hu, Xiaoxi Su, Lu Ji, Peng Li, King Lun Kingston Mak, Feng Gao, Yi Yang, He Xu, Junjun Ding, Nan Cao, Shuo Li, Wensheng Zhang, Ping Lan, Hao Sun, Jinkai Wang, Ping Yuan. Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers. Nucleic acids research. 2020 Jul 27;48(13):7182-7196. doi: 10.1093/nar/gkaa482. (IF:19.160)
5. Mingsen Li, Huaxing Huang, Lingyu Li, Chenxi He, Liqiong Zhu, Huizhen Guo, Li Wang, Jiafeng Liu, Siqi Wu, Jingxin Liu, Tao Xu, Zhen Mao, Nan Cao, Kang Zhang, Fei Lan, Junjun Ding, Jin Yuan, Yizhi Liu, Hong Ouyang. Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis. Nature Communicaitons. 2021 Jan 18;12(1):420. doi: 10.1038/s41467-020-20713-z.（IF: 17.694）
6. Fuxi Li, Yang Yi, Yanyan Miao, Wenyong Long, Teng Long, Siyun Chen, Weisheng Cheng, Changye Zou, Yueyuan Zheng, Xingui Wu, Junjun Ding, Kaiyu Zhu, Delin Chen, Qiongcong Xu, Jinkai Wang, Qing Liu, Feng Zhi, Jian Ren, Qi Cao and Wei Zhao. N6-Methyladenosine Modulates Nonsense-Mediated mRNA Decay in Human Glioblastoma. Cancer Research. 2019 Nov 15;79(22):5785-5798. （IF: 13.312）
7. Kun-Yong Kim, Yoshiaki Tanaka, Juan Su, Bilal Cakir, Yangfei Xiang, Benjamin Patterson, Junjun Ding, Yong-Wook Jung, Ji-Hyun Kim, Eriona Hysolli, Haelim Lee, Rana Dajani, Jonghwan Kim, Mei Zhong, Jeong-Heon Lee, David Skalnik, Jeong Mook Lim, Gareth J. Sullivan, Jianlong Wang & In-Hyun Park. Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a, Nature Communicaitons. 2018 Jul 3;9(1):2583. doi: 10.1038/s41467-018-04818-0. （IF: 17.694）
8. Songyan Han, Christopher Tan, Junjun Ding, Jianlong Wang, Avi Ma'ayan, Valerie Gouon-Evans. Endothelial cells instruct liver specification of embryonic stem cell-derived endoderm through endothelial VEGFR2 signaling and endoderm epigenetic modifications, Stem Cell Research. 2018 Jul;30:163-170. doi: 10.1016/j.scr.2018.06.004. （IF: 1.587）
9. Diana Guallar, Xianju Bi, Jose Angel Pardavila, Xin Huang, Carmen Saenz, Xianle Shi, Hongwei Zhou, Francesco Faiola, Junjun Ding, Phensinee Haruehanroengra, Fan Yang, Dan Li, Carlos Sanchez-Priego, Arven Saunders, Feng Pan, Victor Julian Valdes, Kevin Kelley, Miguel G. Blanco, Lingyi Chen, Huayan Wang, Jia Sheng, Mingjiang Xu, Miguel Fidalgo, Xiaohua Shen & Jianlong Wang. RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells, Nature Genetics. 2018 Feb 26. doi: 10.1038/s41588-018-0060-9. （IF: 41.307）
10. Chunliu Huang  Junjie Shi  Yibin Guo  Weijun Huang  Shanshan Huang Siqi Ming  Xingui Wu  Rui Zhang  Junjun Ding  Wei Zhao  Jie Jia  Xi Huang Andy Peng Xiang  Yongsheng Shi  Chengguo Yao. A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs, Nucleic Acids Research. 2017 Sep 6;45(15):8647-8660.  （IF: 19.160）
11. Francesco Faiola, Nuoya Yin, Miguel Fidalgo, Xin Huang, Arven Saunders, Junjun Ding, DianaGuallar, BaoyenDang, JianlongWang. NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression, Stem Cell Reports. 2017 Sep 12;9(3):913-926. （IF: 7.294）
12. Arven Saunders, Dan Li, Francesco Faiola, Xin Huang, Miguel Fidalgo, Diana Guallar, Junjun Ding, Fan Yang, Yang Xu, Hongwei Zhou, Jianlong Wang. Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming, Stem Cell Reports. 2017 May 9;8(5):1115-1123. （IF: 7.294）
13. Bo Yang, Yi Qiu, Niu Zhou, Hong Ouyang, Junjun Ding, Bin Cheng, Jianbo Sun. Application of Stem Cells in Oral Disease Therapy: Progresses and Perspectives. Frontiers in Physiology. 2017 Apr 3;8:197. Review. （IF: 4.755）
14. Arven Saunders, Xin Huang, Miguel Fidalgo, Michael H. Reimer Jr., Francesco Faiola, Junjun Ding, Carlos Sánchez-Priego, Diana Guallar, Carmen Sáenz, Dan Li, Jianlong Wang. The SIN3A/HDAC Corepressor Complex Functionally Cooperates with NANOG to Promote Pluripotency, Cell Reports. 2017 Feb 14;18(7):1713-1726. （IF: 9.995）
15. Miguel Fidalgo, Xin Huang, Diana Guallar, Carlos Sanchez-Priego, Victor Julian Valdes, Arven Saunders, Junjun Ding, Wen-Shu Wu, Carlos Clave, Jianlong Wang. Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States, Cell Stem Cell. 2016 Jun 21. （IF: 25.269）
16. Jiao Yang, Renpeng Guo, Hua Wang, Xiaoying Ye, Zhongcheng Zhou, Jiameng Dan, Haiying Wang, Peng Gong, Wei Deng, Yu Yin, ShiQing Mao, Lingbo Wang, Junjun Ding, Jinsong Li, David L. Keefe, Meelad M. Dawlaty, Jianlong Wang, GuoLiang Xu, Lin Liu. Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs, Cell Reports. 2016 May 24;15(8):1809-21. （IF: 9.995）
17. Miguel Fidalgo, Francesco Faiola, Carlos-Filipe Pereira, Junjun Ding, Arven Saunders, Julian Gingold, Christoph Schaniel, Ihor R. Lemischka, José C. R. Silva, and Jianlong Wang. Zfp281 mediates Nanog   autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming, Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16202-7. （IF: 12.779）
18. Yen-Sin Ang, Su-Yi Tsai, Dung-Fang Lee, Jonathan Monk, Jie Su, Kajan Ratnakumar, Junjun Ding, Yongchao Ge, Henia Darr, Betty Chang, Jianlong Wang, Michael Rendl, Emily Bernstein, Christoph Schaniel and Ihor R. Lemischkar. Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network, Cell. 2011, Volume 145, Issue 2, 15 April 2011, Pages 183-197. （IF: 66.850）

Award honor

National Fund for Outstanding Young People in 2024
In 2017, the "Pearl River Talent Plan" of Guangdong Province introduced innovative and entrepreneurial teams
(Leader)
2017 Stem Cell Annual Meeting Youth Forum First prize (only one)
2016 National Overseas High-level Talents Program of the Organization Department of the CPC Central Committee (Youth Project)
2015 Sun Yat-sen University hundred people plan

Fund project

National Science Foundation for Distinguished Young People, Chair, Regulation of Chromatin Three-dimensional Structure of pluripotent Stem Cells, Project approval number: 32425022, year: 2025-2029
Guangdong Province introduced innovation and entrepreneurship team, team leader, iPS cell-derived tissue Construction and Research and development of new technologies for the treatment of major diseases, Project number: 2016ZT06S029, year: 2017-2022
Key Project of Guangdong Provincial Natural Science Foundation, Host, Molecular mechanism of breast cancer development, drug resistance and metastasis based on iPS cell breast cancer model, Project number: 2021B1515120063, year: 2021-2024
Cell fate-determining transcription factors regulate cell fate by inducing TAD recombination of chromatin three-dimensional structure. Project Approval number: 32170798, year: 2022-2025
Project of the National Natural Science Foundation of China, Function and Mechanism of nuclear spatial Epigenetic domain regulating neural differentiation. Project Approval number: 31970811, Year: 2020-2023
Research on function and mechanism of DNA-binding protein Arid3b in the establishment of pluripotency and Directed differentiation of stem cells, project number: 31771639, year: 2018-2021

other

Postdoctoral researcher in this laboratory.
Requirements (Those who meet any of these requirements can apply) :
For those with a background in bioinformatics research (monthly allowance may be appropriately increased);
Have a background in epigenetic research;
Background in stem cell or cancer research;
Position treatment
The annual salary is not less than 260,000 yuan (including five insurance and two funds).
To assist in the application of Yi Xian postdoctoral program, the annual salary is not less than 500,000 yuan (including five insurance and two funds). Those who have obtained a doctoral degree abroad and meet the requirements can apply for the \"Guangdong Postdoctoral Talent Introduction Program\" and other postdoctoral talent programs, and can receive up to 1 million yuan of funding.
During the station, postdoctoral apartments are provided, and children can apply for admission to primary and secondary schools and kindergartens affiliated to Sun Yat-sen University.
We fully support postdocs to apply for various funds and talent projects, and excellent candidates can apply for the teaching and research post teacher series prepared by the university.

You are also welcome to apply for my master's degree and doctoral degree.