Personal profile

CAI Weibin, male, born in Wuxue, Hubei Province, Doctor of Medicine, doctoral supervisor, third-grade professor, Yixian Scholar (Excellent scholar post) of Sun Yat-sen University.
He is currently the director of the Laboratory Animal Center of Sun Yat-sen University and the Director of the Engineering Technology Research Center of Disease Model Animals of Guangdong Province. He is also the executive Chairman of Sun Yat-sen University Laboratory Animal Use and Management Committee (IACUC), the member of the Laboratory Safety Committee of Sun Yat-sen University, the executive vice chairman of Guangdong Experimental Animal Society, the executive director of Chinese Society of Experimental Animals, the vice chairman of the Certification committee of Chinese Society of Experimental Animals, and the member of the Professional committee of Laboratory animal Standardization of Chinese Society of Experimental Animals Standing member of the Association, member of the Working Committee for the Identification and Evaluation of Experimental animal Models of the Chinese Society of Experimental Animals, deputy chief editor of the national planning textbook Medical Experimental Zoology (3rd edition, for graduate students), and deputy chief editor of the national planning textbook Experimental Zoology (3rd edition, for undergraduate students).
In 1999, he graduated from Hubei Medical University (now Wuhan University School of Medicine) with a bachelor's degree in Clinical Medicine. 2007 Graduated from Sun Yat-sen University with a Doctor of Medicine degree; Postdoctoral research at Mount Sinai Medical Center, NY, USA from July 2010 to September 2012; Promoted to professor at the end of 2013. It is mainly committed to the molecular basic research of heart development and injury repair, disease model animal development and standardization, and focuses on the applied basic research oriented to clinical major diseases. In recent years, he has published more than 60 works (31 first author or corresponding author) in Nat Commun, Nat Immunol, Redox Biology, Cell Reports, Theranostics and other journals, and 7 invention patents and copyright licenses. He has presided over 8 projects of National Natural Science Foundation, 2 projects of National key research and development Plan and more than 10 projects of provincial and ministerial funds.
He has more than 20 years of teaching experience, and is responsible for the teaching of "Medical Experimental Zoology" and "Translational Medicine Frontier Technology", mainly teaching biochemistry and molecular biology theory courses for medical graduate students and undergraduates, experimental animal theory course, translational medicine frontier technology theory course, and deputy editor of national planning textbooks "Medical Experimental Zoology" and "Experimental Zoology".
He has won the second prize of Natural Science Award of the Ministry of Education, the second prize of Science and Technology Award of Guangdong Province, the first prize of Medical Science and Technology Award of Guangdong Province, the first prize of Natural Science Award of Precision Medicine Science and Technology Award and other awards, and won the "Outstanding Young Talent Award" of the Chinese Society of Laboratory Animals in 2020.

Academic achievement

Representative academic papers published in the last 5 years (* Corresponding author) :

1. Huang TS, Wu T, Fu XL, Ren HL, He XD, Zheng DH, Tan J, Shen CH, Xiong SJ, Qian J, Zou Y, Wan JH, Ji YJ, Liu MY, Wu YD, Li XH, Li H, Zheng K, Yang XF, Wang H, Ren M, Cai WB*. SREBP1 induction mediates long-term statins therapy related myocardial lipid peroxidation and lipid deposition in TIIDM mice. Redox Biol. 2024 Oct 28;78:103412. 
2. He X, Zhang X, Wu B, Deng J, Zhang Y, Zhu A, Yuan Y, Lin Y, Chen A, Feng J, Wang X, Wu S, Liu Y, Liu J, Wang Y, Li R, Liang C, Yuan Q, Liang Y, Fang Q, Xi Z, Li W, Liang L, Zhang Z, Tang H, Peng Y, Ke C, Ma X, Cai W, Pan T, Liu B, Deng K, Chen J, Zhao J, Wei X, Chen R, Zhang Y, Zhang H. The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis. Nat Immunol. 2024 Apr;25(4):622-632. 
3. Huang C, Wang X, Wang Y, Feng Y, Wang X, Chen S, Yan P, Liao J, Zhang Q, Mao C, Li Y, Wang L, Wang X, Yi W, Cai W, Chen S, Hong N, He W, Chen J, Jin W. Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47. Nat Cancer. 2024 Mar;5(3):500-516. 
4. Wu Y, Huang T, Li X, Shen C, Ren H, Wang H, Wu T, Fu X, Deng S, Feng Z, Xiong S, Li H, Gao S, Yang Z, Gao F, Dong L, Cheng J, Cai WB*. Retinol dehydrogenase 10 reduction mediated retinol metabolism disorder promotes diabetic cardiomyopathy in male mice. Nat Commun. 2023 Mar 2;14(1):1181.
5. Huang TS, Wu T, Wu YD, Li XH, Tan J, Shen CH, Xiong SJ, Feng ZQ, Gao SF, Li H, Cai WB*. Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice. Nat Commun. 2023 Jan 24;14(1):390.
6. Li X, Wang H, Wu Y, Zou L, Deng S, Fu X, Huang T, Shen C, Wu T, Cai WB*. A novel mouse model of PEDF-associated serious liver inflammation, hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis. Genes Dis. 2023 Mar 23;11(1):11-14. 
7. Yang M, Xiong S, Tan J, Li Y, Shen C, Wu T, Fu X, Feng Z, Ji Y, Zheng H, Cai WB*. Tumor-Bearing Induces Cardiomyopathy by Disrupting Cardiometabolic Reprogramming. Circulation. 2022 Oct 30;146:A10825（Abstract）
8. Tan J, Yang M, Wang H, Shen C, Wu M, Xu H, Wu Y, Li Y, Li X, Huang T, Deng S, Yang Z, Gao S, Li H, Zhou J, Chen H, Cao N, Cai WB*. Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch. Cell Rep. 2022 Mar 8;38(10):110468.
9. Li Y, Yang M, Tan J, Shen C, Deng S, Fu X, Gao S, Li H, Zhang X, Cai WB*. Targeting ACSL1 promotes cardiomyocyte proliferation and cardiac regeneration. Life Sci. 2022 Apr 1;294:120371.
10. Zhang Z, Yuan Y, Hu L, Tang J, Meng Z, Dai L, Gao Y, Ma S, Wang X, Yuan Y, Zhang Q, Cai WB*, Ruan X*, Guo X*. ANGPTL8 accelerates liver fibrosis mediated by HFD-induced inflammatory activity via LILRB2/ERK signaling pathways. J Adv Res. 2022 Aug 27:S2090-1232(22)00174-6.
11. Jing Tan, Ming Yang, Haiping Wang, Yandi Wu, Yuanlong Li, Shijie Deng, Tongsheng Huang, Conghui Shen, Xinghui Li, Weibin Cai*. Limited Reduction of Heart Rate Promotes Cardiac Regeneration by Switching the Energy Metabolic Mode in Cardiomyocytes. Circulation Research. 2020;127:A338（Abstract）
12. Peng X, Fan S, Tan J, Zeng Z, Su M, Zhang Y, Yang M, Xia L, Fan X, Cai WB*, Tang WH*. Wnt2bb Induces Cardiomyocyte Proliferation in Zebrafish Hearts via the jnk1/c-jun/creb1 Pathway. Front Cell Dev Biol. 2020 May 25;8:323.
13. Li XH, Wu YD, Zhao JJ, Wang HP, Tan J, Yang M, Li YL, Deng SJ, Gao SF, Li H, Yang ZY, Yang FM, Ma JX, Cheng JD, Cai WB*. Distinct cardiac energy metabolism and oxidative stress adaptations between obese and non-obese type 2 diabetes mellitus. Theranostics 2020; 10(6): 2675-2695.
14. Wang H, Yang Y, Yang M, Li X, Tan J, Wu Y, Zhang Y, Li Y, Hu B, Deng S, Yang F, Gao S, Li H, Yang Z, Chen H, Cai WB*. Pigment Epithelial-Derived Factor Deficiency Accelerates Atherosclerosis Development via Promoting Endothelial Fatty Acid Uptake in Mice with Hyperlipidemia. J Am Heart Assoc. 2019 Nov 19;8(22):e013028.
15. Cai WB*, Tan J, Yan J, Zhang L, Cai X, Wang H, Liu F, Ye M, Cai CL. Limited Regeneration Potential with Minimal Epicardial Progenitor Conversions in the Neonatal Mouse Heart after Injury. Cell Rep. 2019 Jul 2;28(1):190-201.
16. Li S, Qiu J, Qin L, Peng P, Li C, Mao J, Fang G, Chen Z, Lin S, Fu Y, Cai WB*, Ding Y*. NOD2 negatively regulated titanium particle-induced osteolysis in mice. Biomater Sci. 2019 Jul 1;7(7):2702-2715.
17. Li XH, Wang HP, Tan J, Wu YD, Yang M, Mao CZ, Gao SF, Li H, Chen H, Cai WB*. Loss of pigment epithelium-derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice. Life Sci. 2019 Jan 1; 216:129-139.

Academic part-time job

Director, Laboratory Animal Center, Sun Yat-sen University
Director of Guangdong Province Disease Model Animal Engineering Technology Research Center
Executive Chairman, Laboratory Animal Use and Management Committee (IACUC), Sun Yat-sen University
Member of Laboratory Safety Committee, Sun Yat-sen University
Executive Vice president of Guangdong Experimental Animal Society
General consultant of large animal Model Research Center of Guangdong Province
Deputy Chairman of the Academic Committee of Guangdong Provincial Key Laboratory of Laboratory Animals
Executive Director of Chinese Society of Laboratory Animals
Vice Chairman of the Certification Committee of Laboratory animal institutions, Chinese Society of Laboratory Animals
Standing member of the Professional Committee of Laboratory Animal Standardization, Chinese Society of Laboratory Animals
Member of the Working Committee of Laboratory Animal Model Identification and Evaluation, Chinese Society of Laboratory Animals