Personal Introduction
Huang Chaofeng, Ph.D., Associate Professor and Doctoral Supervisor at the School of Basic Medical Sciences, Sun Yat-sen University. In 2003, he graduated from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and obtained a Ph.D. in Genetics. In 2004, he worked as a postdoctoral fellow in the Department of Microbiology and Immunology at the University of Illinois College of Medicine in the United States; since 2009, he has served as an Assistant Researcher in the Nutrition Immunology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging; he was recruited by Sun Yat-sen University in March 2010. Main research directions: 1. The mechanism and clinical application of the regulation of Th17 cell differentiation and functional activity. 2. Exploration of the clinical application of immune cell therapy technology in anti-tumor and autoimmune diseases. In recent years, he has cumulatively published more than 30 papers in professional journals such as Nature Immunology and Journal of Immunology, applied for and obtained more than 10 invention patents, and applied for 1 PCT international patent which has entered multiple countries and regions. He has presided over a number of national natural science funds and major scientific research projects at the provincial and municipal levels, including general projects of the National Natural Science Foundation of China, Guangdong Science and Technology Program, and Guangzhou Special Project for Foreign Scientific and Technological Cooperation, with a total funding of more than 4 million yuan.

Academic Achievements
Academic Works and Textbooks:

1. Yang Y, Deng Y, Zhang G, Xu X, Xiong X, Yu S, Peng F, Tian X, Ye W, Chen H, Yu B, Liu Z, He X, Huang Z. α-mangostin derivatives ameliorated mouse DSS-induced chronic colitis via regulating Th17/Treg balance. Mol Immunol. 2024 Feb;166:110-118. doi: 10.1016/j.molimm.2023.11.013
2. Chen H, Yang Y, Deng Y, Wei F, Zhao Q, Liu Y, Liu Z, Yu B, Huang Z. Delivery of CD47 blocker SIRPα-Fc by CAR-T cells enhances antitumor efficacy. Journal for Immunotherapy of Cancer. 2022;10(2). (IF: 13.751)
3. Huanpeng Chen, Fengjiao Wei, Meng Yin, Qingyu Zhao, Zhonghua Liu, Bolan Yu, Zhaofeng Huang*. CD27 enhances the killing effect of CAR T cells targeting trophoblast cell surface antigen 2 in the treatment of solid tumors. Cancer Immunol Immunother. 2021 Jul;70(7):2059-2071.
4. Xuyan Tian, Lipeng Tang, Fengjiao Wei, Huanpeng Chen, Longxiang Sheng, Yuying Yang, Xiaoqing Zhou, Yongchao Li, Xiaoting Xu, Boyang Zhang, Zhonghua Liu, Yu Lei, Bolan Yu, Chuan Bai, Xixin He*, Zhaofeng Huang*. Pentacyclic triterpene compounds from loquat leaves reduce skin inflammation and epidermal hyperplasia in psoriasis via inhibiting the Th17 cells [J]. Mol Immunol. 2021 Apr;132:30-40.
5. Wei F, Zhou X, Chen H, Tian X, Liu Z, Yu B, He X, Bai C*, Huang Z*. 5,6,7,8- Tetrahydrobenzo [4,5]thieno[2,3-d]pyrimidine derivative attenuates lupus nephritis with less effect to thymocyte development. Immunol Res. 2021 Aug;69(4):378-390.
6. Zhou X, Chen H, Wei F, Zhao Q, Su Q, Lei Y, Yin M, Tian X, Liu Z, Yu B, Bai C, He X*, Huang Z*. α-mangostin attenuates pristane-induced lupus nephritis by regulating Th17 differentiation. Int J Rheum Dis. 2020 Jan;23(1):74-83. doi: 10.1111/1756-185X.13743.
7. Zhou X, Chen H, Wei F, Zhao Q, Su Q, Lei Y, Yin M, Tian X, Liu Z, Yu B, Bai C, He X*, Huang Z*. The Inhibitory Effects of Pentacyclic Triterpenes from Loquat Leaf against Th17 Differentiation. Immunol Invest. 2020 Aug;49(6):632-647. doi: 10.1080/08820139. 2019. 1698599.
8. Zhou X, Chen H, Wei F, Zhao Q, Su Q, Liang J, Yin M, Tian X, Liu Z, Yu B, Bai C, He X*, Huang Z*. 3β-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation. J Immunol Res. 2019 May 22;2019:2431617. doi: 10.1155/2019/2431617.
9. Lao C, Zhou X, Chen H, Wei F, Huang Z*, Bai C* 5,6,7,8-Tetrahydrobenzo [4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt. Bioorg Chem. 2019, 90:103077. doi: 10.1016/j.bioorg. 2019. 103077.
10. Wu X, Huang J, Dai L, Zhou J, Huang Z, Yu B* Adolescent diabetes induced by multiple parental exposures to cigarette smoke condensate. Toxicol Lett. 2019 Oct 10;314:98-105. doi: 10.1016/j.toxlet.2019.07.012.
11. Wu K, Li Y, Zhang S, Zhou N, Liu B, Pan T, Zhang X, Luo H, Huang Z, Li X, Zhang H, Zhang J*. Preferential Homing of Tumor-specific and Functional CD8+ Stem Cell-like Memory T Cells to the Bone Marrow. J Immunother. 2019, 42(6):197-207. doi: 10.1097/CJI.0000000000000273.
12. Wu K, Zhang S, Zhang X, Li X, Hong Z, Yu F, Liu B, Pan T, Huang Z, Tang XP, Cai W, Xia J, Li X, Zhang H, Zhang Y*, Li L*. IL-21 Expands HIV-1-Specific CD8+ T Memory Stem Cells to Suppress HIV-1 Replication In Vitro. J Immunol Res. 2019, 2019:1801560. doi: 10.1155/2019/1801560.
13. Sheng L, Lu B, Chen H, Du Y, Chen C, Cai W, Yang Y, Tian X, Huang Z, Chi W, Lin S, Yan G, Yin W. Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia⁻Reperfusion Injury by Activating Nrf2 Pathway. Mar Drugs. 2019,17(5). pii: E267. doi: 10.3390/md1705026.
14. Zhao G, Mo J, Zheng T, Li Y, Wu X, Huang J, Liu G, Huang Z*, Yu B*. Puberty exposure to cigarette smoke extract impairs adult spermatogenesis in the mouse. Reprod Toxicol. 2019,83:8-13. doi: 10.1016/j.reprotox.2018.10.012.
15. Zhiheng He ; Zhang J; Huang Z; Du Q; Li N; Zhang Q; Chen Y; Sun Z * Sumoylation of RORγt regulates TH17 differentiation and thymocyte development., Nat Commun, 2018, 9(1) p.4870
16. Zhao, C.-L., Xia, Y.-X., Ye, J.-H., Ku, C.F., Li, W.-F., Luo, G.-Y., Zhang, J.-J., Xu, J., Huang, ZF., Tsang, S.W. et al. (2018). Isolation, evaluation of bioactivity and structure determination of amethinol A, a prototypic amethane diterpene from Isodon amethystoides bearing a six/five/seven-membered carbon-ring system.Acta Crystallogr C Struct Chem. 2018 , 74(Pt 5):635-640. doi: 10.1107/S2053229618005740.
17. He Z#, Ma J#, Wang F, Wang R, Huang Z, Zhang J, Sen S, Rothenberg E, Sun Z* Two amino acid mutation disrupts RORgt function in Th17 differentiation but not thymocyte development . Nature Immunology 2017, 18(10): 1128-1138. doi: 10.1038/ni.3832.
18. Xu X, Huang J, Zhao M, Chen H, Mo J, Zhou X, Su Q, Yu B and Huang Z*. Stabilized ß-catenin ameliorates ALPS-like symptoms of B6/lpr mice. Journal of Immunology research. 2017, Article ID 3469108. doi.org/10.1155/2017/ 3469108 .
19. Xu X, Yu B, Cai W, Huang Z*. TCF1 deficiency ameliorates autoimmune lymphoproliferative syndrome (ALPS)-like phenotypes of lpr/lpr mice. Scand J Immunol. 2017，85：406-416. doi: 10.1111/sji.12546.
20. Zhao M, Chen H, Ding Q, Xu X, Yu B, Huang Z*. Nuclear Factor Erythroid 2-related Factor 2 Deficiency Exacerbates Lupus Nephritis in B6/lpr mice by Regulating Th17 Cell Function. Sci Rep. 2016, 6:38619. doi: 10.1038/srep38619
21. Yu B, Huang Z*. Variations in Antioxidant Genes and Male Infertility.Biomed Res Int. 2015:513196. doi: 10.1155/2015/513196.
22. Yu B, Zhou H, Liu M, Zheng T, Jiang L, Zhao M, Xu X, Huang Z*. Epigenetic Alterations in Density Selected Human Spermatozoa for Assisted Reproduction. PLoS One. 10(12):e0145585. doi: 10.1371/journal.pone.0145585.
23. Ding Q, Zhao M, Yu B, Bai C, Huang Z*. Identification of tetraazacyclic compounds as novel potent inhibitors antagonizing RORγt activity and suppressing Th17 cell differentiation. plos one 2015 , 10(9):e0137711 DOI: 10.1371/journal.pone.0137711
24. Ding Q, Zhao M, Bai C, Yu B, Huang Z*. Inhibition of RORγt activity and Th17 differenti ation by a set of novel compounds. BMC immunology 2015, 16:32. DOI: 10.1186/s12865-015-0097-9
25. Yu B , Ding Q, Zheng T, Jiang L, Li Q, Sun X, Bai C and Z. Huang*. Smoking attenuated the association between IκBα rs696 polymorphism and defective spermatogenesis in humans. ANDROLOGIA 2015,47(9): 987–994 DOI: 10.1111/and.12368
26. Yu B, Qi Y, Liu D, Gao X, Chen H, Bai C, Huang Z*. Cigarette smoking is associated with abnormal histone-to-protamine transition in human sperm. Fertil Steril. 2014, 101(1):51-57.
27. Chen J, Yang L, Huang Z*. The N-terminal 33 amino acid sequence of Siva-1 is
    sufficient for nuclear localization. Brazilian Journal of Medical and Biological Research 2013, 46(12): 1021-1027.
28. Yu B, Chen J, Liu D, Zhou H, Xiao W, Xia X, Huang Z*. Cigarette smoking is associated with human semen quality in synergy with functional NRF2 polymorphisms. Biol Reprod. 2013, 89(1):5.
29. Yu B, Mai Z, Liu X, Huang Z*. Selective estrogen receptor modulator BC-1 activates antioxidant signaling pathway in vitro via formation of reactive metabolites. Acta Pharmacol Sin. 34(3):373-9. 2013
30. Molano A, Huang Z, Marko MG, Azzi A, Wu D, Wang E, Kelly SL, Merrill AH Jr, Bunnell SC, Meydani SN. PLoS One. 2012;7(10):e47650. doi: 10.1371/journal.pone.0047650.
31. Yu B, Lin H, Yang L, Chen K, Luo H, Liu J, Gao X, Xia X, Huang Z*. Genetic variation in the Nrf2 promoter associates with defective spermatogenesis in humans. J Mol Med (Berl). 2012, 90(11):1333-42.

Scientific Research Projects
Projects Presided Over:
General Project of the National Natural Science Foundation of China: Molecular mechanism of β-Catenin regulating the apoptosis of T cells after activation. 31170831, January 2012 - December 2015, 600,000 yuan
Special Project for Public Welfare Construction and Capacity Building of the Department of Science and Technology of Guangdong Province: A model of early-onset systemic lupus erythematosus co-induced by environmental oxidative stress and NRF2 gene deficiency. 2015A030302016, July 1, 2015 - December 31, 2017, 100,000 yuan
Guangdong-Hong Kong Joint Innovation Project in Guangdong Province: Searching for natural small-molecule inhibitors of RORγt from Lingnan medicinal plants and their application in the treatment of lupus nephritis. 2016A050503023, January 1, 2016 - December 31, 2018, 1 million yuan
Special Project for International Cooperation in Guangdong Province: Establishment of a target-specific evaluation system for novel Th17 cell differentiation inhibitors. 2017A050501010, January 1, 2017 - December 31, 2019, 500,000 yuan
General Project of the Natural Science Foundation of Guangdong Province: Molecular mechanism of the inhibitory effect of active substances in mangosteen on the activity of RORγt and the function of Th17 cells. 2021A1515010339, January 2021 - December 2023. Project Leader, completed, Department of Science and Technology of Guangdong Province
General Project of the Natural Science Foundation of Guangdong Province: The mechanism of action of tetrazacyclic thiophenopyrimidine in targeting and regulating the activity of RORγt and its application in the treatment of autoimmune diseases. 2022A1515011758, January 2022 - December 2024. Project Leader, ongoing, Department of Science and Technology of Guangdong Province.

Participation in Talent Projects:
Project of the Pearl River Talent Program in Guangdong Province for the Introduction of Scientific Research and Innovation Teams, "Research and Development of Specific Drugs for Major Human Pathogenic Viruses and the Regenerative Engineering of Immune Cells", Core Member and Leader of the Third Sub-project. 2009010058, June 2010 - December 2017, with a total of 80 million yuan, responsible for 1 million yuan of the sub-project

Academic Appointments
Council Member of the Guangdong Precision Medicine Application Association, Director of the Disease Model Branch, and Deputy Director of the Immunotherapy Branch.