Personal Profile
Currently, I am an associate professor in the Department of Physiology of the School of Basic Medical Sciences and a supervisor for master's students. I graduated from the Department of Clinical Medicine of Baotou Medical College in 1995 and obtained a bachelor's degree. In 2000, I graduated from Sun Yat-sen Medical University and received a master's degree in Physiology. In 2009, I was awarded a doctoral degree in Physiology from Sun Yat-sen University. From October 2005 to October 2006, I conducted postdoctoral research at INSERM/UCBL-U628 in France, focusing on the research of sleep mechanisms.
In recent years, my main research has been focused on the mechanisms of morphine analgesic tolerance and pathological pain. As the principal investigator, I have received funding from the National Natural Science Foundation of China, the Natural Science Foundation of Guangdong Province, and the Science and Technology Planning Project of Guangdong Province, etc. As a major collaborator, I have participated in several projects funded by the National Natural Science Foundation of China and the Science and Technology Planning Project of Guangdong Province. I have also served as an editorial board member and participated in the compilation of several textbooks.

Academic Achievements
Main relevant published papers

1. Lv YY, Wang H, Fan HT, Xu T, Xin WJ, Guo RX*. SUMOylation of Kir7.1 participates in neuropathic pain through regulating its membrane expression in spinal cord neurons. CNS Neurosci Ther. 2022, 28(8):1259–1267.
2. Mao Z, Huang R, Jing Xu, Guo RX*, Wei XH*. Liver X Receptor α in Sciatic Nerve Exerts an Alleviating Effect on Neuropathic Pain Behaviors Induced by Crush Injury. Neurochem Res. 2021, 46(2):358-366. ISSN 0364-3190. (IF2019: 3.038)
3. Liu M, Zhang SB, Luo YX, Yang YL, Zhang XZ, Li B, Meng Y, Chen YJ, Guo RX*, Xiong YC, Xin WJ, Li D*. NFATc2-dependent epigenetic upregulation of CXCL14 is involved in the development of neuropathic pain induced by paclitaxel. J Neuroinflammation. 2020 Oct 18;17(1):310.
4. Shen N, Mo LQ, Hu F, Chen PX, Guo RX*, Feng JQ*. A Novel Role of Spinal Astrocytic Connexin 43: Mediating Morphine Antinociceptive Tolerance by Activation of NMDA Receptors and Inhibition of Glutamate Transporter-1 in Rats. CNS Neurosci Ther. 2014, 20(8): 728-36.
5. Guo RX, Anaclet C, Roberts JC, Parmentier R, Zhang M, Guidon G, Buda C, Sastre JP, Feng JQ, Franco P, Brown SH, Upton N, Medhurst AD, Lin JS. Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice. Br J. Pharmacol. 2009, 159(1): 104-117.
6. Guo RX, Zhang M, Liu W, Zhao CM, Cui Y, Wang CH, Feng JQ, Chen PX . NMDA receptors are involved in upstream of the spinal JNK activation in morphine antinociceptive tolerance. Neurosci Lett. 2009, 467(2): 95-9.
7. He J, Guo R, Qiu P, Su X, Yan G, Feng J. Exogenous hydrogen sulfide eliminates spatial memory retrieval impairment and hippocampal CA1 LTD enhancement caused by acute stress via promoting glutamate uptake. Neuroscience. 2017 May 14; 350:110-123.
8. Zhao CM, Guo RX, Hu F, Meng JL, Mo LQ, Chen PX, Liao XX, Cui Y, Feng JQ. Spinal MCP-1 Contributes to the Development of Morphine Antinociceptive Tolerance in Rats. Am J Med Sci. 2012, 344(6): 473-9.
9. Zhang M, Guo RX, Mo LQ, Liao XX, Li W, Zhi JL, Sun SN, Wang YL, Cui Y, Liu W, Feng JQ, Chen PX. Nuclear factor-κB mediates cytoprotection of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress in PC 12 cells. Clin.Exp. Pharmaco.P. 2009, 36(3): 304-311.

10. Hu F, Cui Y, Guo RX, Chen JF, Guo RM, Shen N, Hua XX, Mo LQ, Feng JQ. Spinal leptin contributes to the development of morphine antinociceptive tolerance by activating the STAT3-NMDA receptor pathway in rats. Mol Med Rep. 2014, 10: 923-930.

     

Textbooks and Monographs
Editorial Board Member, Physiology (4th Edition), Higher Education Press, 2023
Editorial Board Member, Essentials of Physiology for the National Medical Comprehensive Ability Examination (Western Medicine), People's Medical Publishing House, 2022
Editorial Board Member, Physiology in the Chinese Medical Education Question Bank, People's Medical Publishing House, 2021
Editorial Board Member, Essentials of Physiology Learning, People's Medical Electronic Audio-Visual Publishing House, 2020
Editorial Board Member, National Medical E-textbook: Physiology, People's Military Medical Press, 2017

Scientific Research Projects

1. General Project of the Natural Science Foundation of Guangdong Province, Project No. 2020A1515011306, "The Interaction between Glial Cells and Neurons Mediated by CXCL12/CXCR4 in the Spinal Cord and Its Involvement in the Formation of Chronic Morphine Analgesic Tolerance and the Underlying Mechanisms", from October 2019 to September 2023, with a funding of 100,000 yuan, Principal Investigator.
2. General Project of the National Natural Science Foundation of China, Project No. 81973020, "The Effect and Mechanism of n-3 Polyunsaturated Fatty Acids on the Metastasis and Prognosis of Colorectal Cancer by Inhibiting Epithelial-Mesenchymal Transition (EMT) through Activating PPARγ", from January 1, 2020 to December 31, 2023, with a funding of 560,000 yuan, Participant (ranked 2nd).
3. General Project of the Natural Science Foundation of Guangdong Province, Project No. 2017A030313132, "The Interaction between Astrocytes and Neurons Mediated by Gap Junctions and Its Involvement in the Formation of Morphine Analgesic Tolerance and the Underlying Mechanisms", from May 2017 to May 2020, with a funding of 100,000 yuan, Principal Investigator.
4. Medical Science and Technology Research Foundation of Guangdong Province, Project No. A2015415, "The Role of the Spinal Cx43-Glu-NMDA-R Pathway in Morphine Analgesic Tolerance", from July 2015 to June 2017, with a funding of 5,000 yuan, Principal Investigator.
5. Science and Technology Planning Project of Guangdong Province, Project No. 2013B022000001, "The Role of Spinal Gap Junction Protein Cx43 in Astrocyte-mediated Morphine Tolerance", from December 2014 to November 2017, with a funding of 50,000 yuan, Principal Investigator.
6. Young Scientists Fund of the National Natural Science Foundation of China, Project No. 1100827, "The Molecular Mechanism of NR2B-JNK Signaling Pathway Mediated Morphine Analgesic Tolerance in Rats", from January 2012 to December 2014, with a funding of 210,000 yuan, Principal Investigator.
7. Doctoral Startup Project of the Natural Science Foundation of Guangdong Province, Project No. S2011040002763, "The Role of the JNK-MCP-1/CCR2-NMDA-R Pathway in Morphine Analgesic Tolerance", from October 2011 to October 2013, with a funding of 30,000 yuan, Principal Investigator.

Awards and Honors
As the principal investigator, I have received funding from the National Natural Science Foundation of China, the Natural Science Foundation of Guangdong Province, and the Science and Technology Planning Project of Guangdong Province. As a major collaborator, I have participated in several projects funded by the National Natural Science Foundation of China and the Science and Technology Planning Project of Guangdong Province. I have also served as an editorial board member and participated in the compilation of several textbooks.