Personal Profile
Bai Chuan, Ph.D. in Medicinal Chemistry, Associate Professor and Doctoral Supervisor at the School of Basic Medical Sciences, Sun Yat-sen University.
Graduated from the West China School of Pharmacy, Sichuan University (formerly the School of Pharmacy of West China University of Medical Sciences) with a Bachelor of Science degree from 1995 to 1999.
Obtained a Master of Science in Pharmacognosy from the West China School of Pharmacy, Sichuan University from 1999 to 2002.
Received a Ph.D. in Medicinal Chemistry from the College of Pharmacy, University of Illinois at Chicago from 2004 to 2010.
The main research directions are medicinal chemistry of antiviral and immunomodulatory drugs, and research on small molecule probes related to metabolism and immunity. Up to now, he has published more than ten articles in authoritative journals, obtained 6 national invention patents, and completed 1 patent transfer; presided over 6 national, provincial and municipal projects, 1 horizontal project, and won the Second Prize of the Guangdong Province Science and Technology Progress Award (ranked 8th).

Academic Achievements
Published Articles:

1. Qiliang Zhang, Ziwen Li, Tao Liu, Jun Li(*), Chuan Bai (*), Synthesis of Plasmalogen Derivatives with Unnatural Fatty Acids as Substrates for Ferroptosis Induction， ACS Chem. Biol. 2024, (19), 1883−1887.  (IF=4.63)
2. Yinyi Gao, Kaili Li, Lijun Zhang, Chu Chen, Chuan Bai (*), A nucleophilic chemical probe targeting electrophilic functional groups in an untargeted way to explore cysteine modulators in natural products， ACS Chem. Biol. 2022, (17), 1685−1690.  (IF=4.63) 
3. Ruiqin Ye, Lifang Sun, Jinhui Peng, Aixin Wu, Xiaozhu Chen, Lu Wen, Chuan Bai (*), Gang Chen (*),  Design, Synthesis, and Biological Evaluation of Dexamethasone-Salvianolic Acid B Conjugates and Nanodrug Delivery against Cisplatin-Induced Hearing Loss, J. Med. Chem. 2021, (64), 6, 3115-3130. (IF=7.44)
4. Yinyi Gao, Han Cheng, Sameer Khan, Gaokeng Xiao, Lijun Rong (*), Chuan Bai(*), Development of coumarine derivatives as potent anti-filovirus entry inhibitors targeting viral glycoprotein, Eur. J. Med. Chem. 2020, (204), 112595-614. (IF=5.57)
5. Chuyu Lao, Xiaoqing Zhou, Huanpeng Chen, Fengjiao Wei, Zhaofeng Huang (*), Chuan Bai(*), 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitorsof full-length RORγt, Bioorganic Chemistry, 2019, DOI: https://doi.org/10.1016/j.bioorg.2019.103077. (IF=4.83)
6. Zhu Anyun, Lao Chuyu, Wang Ze, Chen Yang (*), Bai Chuan (*)., Characterization of Crocetin-Monoglucuronide as a Neuron-Protective Metabolite of Crocin-1, Mol Nutr Food Res. 2019 Apr 29:e1900024. (IF=5.03)
7. Pan Ting, Ding Yanchao, Wu Liyang, Liang Liting, He Xin, Li Qqianwen, Bai, Chuan(*), Zhang, Hui (*),  Design and synthesis of aminothiazole based hepatitis B Virus (HBV) capsid inhibitors, Eur. J. Med. Chem. 2019, (166), 480-501. (IF=5.57)
8. Shaoyang Zhang, et al, Chuan Bai, “Identification of an HIV-1 replication inhibitor which rescues hostrestriction factor APOBEC3G in Vif–APOBEC3G complex” Antiviral Research 2015,（122）,20–27. (IF=4.10)
9. Ting Pan, et al, Chuan Bai “Development of benzimidazole derivatives to inhibit HIV-1 replication through protecting APOBEC3G protein” Eur. J. Med. Chem. 2015, (95), 500-513. (IF=5.57)
10. Fudi Zhong, et al, Chuan Bai. “Identification of benzenesulfonamide quinoline derivatives as potent HIV-1 replication inhibitors targeting Rev protein.” Org. Biomol. Chem. 2014, (13), 1792-1799. (IF=3.56)
11. Bai, C., Zhao, L., Tsai, M.D., Bruzik, K.S. “Unique Catalytic Mechanism of Phosphatidylinositol-Specific Phospholipase C from Streptomyces antibioticus.” J. Am. Chem. Soc.2010, 132(4), 1210–1211. (IF=14.61)
12. Bai, C., Zhao, L., Rebecchi, M., Tsai, M.D., Bruzik, K.S. “Trans-cyclization of phosphatidylinositol catalyzed by phospholipase C from Streptomyces antibioticus.”J. Am. Chem. Soc.2009, 131(24): 8362-3. (IF=14.61)

Authorized Patents:
Bai Chuan, Gao Yinyi. Application of Small Molecular Compounds in the Preparation of Drugs against Filoviruses. Invention Patent, 5511943, October 14, 2022.
Bai Chuan, Gao Yinyi. Small Molecular Compounds with Anti-Filovirus Activity and Their Applications. Invention Patent, 5472312, September 23, 2022.
Bai Chuan, Gao Yinyi, Li Kaili. Authorized. A Class of Aryl Heteroamine Derivatives and Their Preparation Methods and Applications. Invention Patent, 6537104, December 05, 2023.
Bai Chuan, Gao Yinyi, Zhang Lijun. A Sesquiterpene Electrophilic Natural Product and Its Isolation, Preparation Method and Application. Invention Patent, 5993629, May 23, 2023.
Bai Chuan, Gao Yinyi. An Electrophilic Molecular Probe Based on Reactive Thiol Groups and Reporter Ions and Its Preparation Method and Application. Invention Patent, 5092184, April 19, 2022.
Bai Chuan, Wu Zhongdao, Qi Ruibing, Zhao Shengye. A Small Molecular Probe for Discovering Active Substances That Can React with Aldehyde Groups. Invention Patent, 6764576, March 08, 2024.

Textbooks and Monographs
Participated in the compilation of Classical Theories and Practical Techniques of Molecular Biology, People's Medical Publishing House, 2024, ISBN 978-7-117-35854-5.

Scientific Research Projects
General Program of the National Natural Science Foundation of China, 2016-2019.
General Program of the National Natural Science Foundation of China, 2019-2022.
General Program of the National Natural Science Foundation of China, 2021-2024.
Guangdong Province Public Welfare Research and Capacity Building Project, 2017-2019.
General Program of the Natural Science Foundation of Guangdong Province, 2024-2026.
Guangzhou City Foreign Science and Technology Cooperation Project, 2017-2020.

Awards and Honors
In 2022, Second Prize of Guangdong Province Science and Technology Progress Award (ranked 8th).

Academic Appointments
Science and Technology Commissioner for Guangdong Enterprises, 2017-2020.
Science and Technology Commissioner for Rural Areas in Guangzhou, 2020-2023.