个人简介

2011年本科毕业于中南大学，2016年博士毕业于中山大学。中山大学中山医学院副教授、广东省杰出青年基金获得者、中山大学 “逸仙新锐学者”。长期从事抗病毒免疫及疫苗免疫的基础和应用研究，致力于解析病毒免疫逃逸监察机制，以及免疫微环境对T淋巴细胞尤其是组织驻留型T细胞免疫应答调控，作为第一作者及通讯作者在Immunity，Nat Immunol，PNAS，Signal Transduct and Tar，Cell Mol Immunol，J Immunother Cancer，Cancer Res，Cell Rep，Adv Sci等发表论文十余篇。主持国家自然科学基金重大研发计划（培育项目）、面上项目及青年项目。

学术成果

第一作者及通讯作者代表性学术论著（按时间排序）：

1, He X#, Zhang X#, Wu B#, Deng J#, Zhang Y#… …Zhao J*, Wei J*, Chen R*, Zhang Y*, Zhang H*; The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis, Nature Immunology, 2024, 25(4) (中科院一区TOP，IF：27.7)

2, Feng J#, Pu Z#, Li R, Li Y, Qin X, Zhang H*, Zhang Y*; Correlation between Circulating T Follicular Helper Cell Levels after Infection and a Decreased Risk of COVID-19 Re-infection. Virologica Sinica (2024): S1995-820X.

3, Chen Y#, Yan S#, Pu Z, Feng J, Tan L, Li Y, Hu H, Huang H, Lin Y, Peng Z, He X, Huang F*, Zhang H*, Zhang Y*. Dopamine/DRD5 Signaling Axis Modulates CD8+ T cells into the CD103+ Tissue-resident Memory Fate and Their Antitumor Immunity. Cancer Research. 2022, 82(17): 3130-3142. (中科院一区TOP，IF：12.5)

4，Zhang Y#, Li R#, Li Y#, Yang H, Zhou L, Yuan J, Pan T, Liu B, Zhang H*, He Y*. Antibody Response and Cross-Neutralization After Omicron BA.2 Infection. Signal Transduction and Targeted Therapy. 2023, 8(1). (中科院一区TOP，IF：40.8)

5，Zhang Y , Chen Y, Li Y, Huang F, Luo B, Yuan Y, Xia B, Ma X, Yang T, Yu F, Liu J, Liu B, Song Z, Chen J, Yan S, Wu L, Pan T, Zhang X, Li R, Huang W, He X, Xiao F, Zhang J*, Zhang H*. The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Downregulating MHC-Ι. Proceedings of the National Academy of Sciences, 2021, 118(23) . (中科院一区TOP，IF：9.4)

6，Zhang Y , Yan S, Hu H, Li Y, Tan L, Chen Y, Peng Z, Yuan Y, Liu W, Huang W, Yu F, He X, Li B*, Zhang H*. Amino Acids and RagD Potentiate mTORC1 Activation in CD8+ T Cells to Confer Antitumor Immunity. Journal for ImmunoTherapy of Cancer, 2021, 9(4). (中科院一区，IF：10.3)

7，Yuan Y#, Zhang X#, Chen R#, Li Y, Wu B, Li R, Zou F, Ma X, Wang X, Chen Q, Deng J, Zhang Y, Chen T, Lin Y, Yan S, Zhang X, Li C, Bu X, Peng Y, Ke C, Deng K, Pan T, He X, Zhang Y*, and Zhang H*. A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-2. Cell Reports. 2021: 110256. (中科院一区，IF：7.5)

8，Ma X#, Zou F#, Yu F#, Li R#, Yuan Y#, Zhang Y#, Zhang X, Deng J, Chen T, Song Z, Qiao D, Zhan Y, Liu J, Zhang J, Zhang X, Peng Z, Li Y, Lin Y, Liang L, Wang G, Chen Y, Chen Q, Pan T, He X, Zhang H. Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses. Immunity. 2020, 53(6): 1315-1330. e9. (中科院一区TOP，IF：25.5)

9，Pan T#, Hu Z#, Hu F#, Zhang Y#, Liu B, Ke C, She Q, He X, Tang X*, Zhang H*. Significantly reduced abilities to cross-neutralize SARS-CoV-2 variants by sera from convalescent COVID-19 patients infected by Delta or early strains. Cellular & Molecular Immunology. 2021: 1-3. (中科院一区TOP，IF：21.8)

10，Zhang Y #, Chen Y#, Ma R, Jiang Y, Liu J, Lin Y, Chen S, Xia M, Zou F, Zhang J, Pan T, Wang L, Wei L*, Zhang H*. UHRF1 Controls Thymocyte Fate Decisions Through the Epigenetic Regulation of EGR1 Expression. TheJournal of Immunology. 2020, 204(12): 3248-3261.

11，Luo B#, Zhan Y#, Liu J, Luo M, Dong H, Liu J, Lin Y, Zhang J, Wang G, Verhoeyen E, Zhang Y*, Zhang H*. Engineered Production of Anti-PD1 Antibody-Expressing Long-lived Plasma Cells by CRISPR/CAS9-Mediated Targeted Gene Integration. Cell Death and Diseases.2020 Nov 12;11(11):973.

12，Zhang Y， Liu W, Chen Y, Liu J, Wu K, Su L, Zhang W, Jiang Y, Zhang X, Zhang Y, Liu C, Tao L, Liu B*, and Zhang H*. A cellular microRNA facilitates regulatory T lymphocyte development by targeting the FOXP3 promoter TATA-box motif. The Journal of Immunology. 2018. 200(3):1053-1063.

13，Pan T, Peng Z, Tan L, Zou F, Zhou N, Liu B, Liang L, Chen C, Liu J, Wu L, Liu G, Peng Z, Liu W, Ma X, Zhang J, Zhu X, Liu T, Li M, Huang X, Tao L, Zhang Y*, and Zhang H*. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Potently Inhibit the Replication of Zika Viruses by Inducing the Degradation of Axl. Journal of Virology. 2018, 92(20): e01018-18.

14，Chen Y#, Yu F #, Jiang Y, Chen J, Wu K, Chen X, Lin Y, Zhang H, Li L*, and Zhang Y*. Adoptive Transfer of Interleukin-21-stimulated Human CD8+ T Memory Stem Cells Efficiently Inhibits Tumor Growth. Journal of Immunotherapy. 2018, 41(6): 274. (IF:4.5).