个人简介

唐忠辉博士，中山大学中山医学院教授，博士生导师。

海外高层次人才引进计划获得者

主要的研究方向为：

1. 聚焦三级淋巴结构 (Tertiary lymphoid structure, TLS) 与引流淋巴结 (Tumor-draining lymph node, TdLN) 在肿瘤免疫应答中的“双枢纽”角色，系统解析其结构-功能异质性与免疫调控机制，揭示其在肿瘤免疫逃逸与免疫治疗响应中的关键作用。
2. 围绕肿瘤微环境空间异质性，开发高分辨率原位组学新技术和人工智能新算法，实现组织功能分子的三维空间可视化与定量分析，为肿瘤免疫机制解析与治疗靶点发现提供方法支撑。

学科专业：分子医学和生物信息学

学术成果

近5年内发表的论著：

(1) Zhonghui Tang; Yinqi Bai; Qi Fang; Yuchen Yuan; Qianwen Zeng; Shuling Chen; Tianyi Xu; Jianyu Chen; Li Tan; Chunqing Wang; Qian Li; Jinpei Lin; Zhuoxuan Yang; Xia Wu; Guowei Shi; Ji Wang; Changjun Yin; Jianping Guo; Shiping Liu; Sui Peng; Ming Kuang; Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures, Cancer Cell, 2025, 43:1-20 (共同第一作者, 共同通讯作者) 

(2) Qizhao Huang; Xia Wu; Zhiming Wang; Xiangyu Chen; Lisha Wang; Yijun Lu; Dan Xiong; Qiao Liu; Yuhan Tian; Huayu Lin; Junyi Guo; Shuqiong Wen; Wei Dong; Xiaofan Yang; Yuchen Yuan; Zhengliang Yue; Shun Lei; Qing Wu; Ling Ran; Luoyingzi Xie; Yifei Wang; Leiqiong Gao; Qin Tian; Xinyuan Zhou; Beicheng Sun; Lifan Xu; Zhonghui Tang; Lilin Ye; The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes, Cell, 2022, 185(22): 4049-4066 (共同通讯作者, 排名第二) 

(3) Yuchen, Liang; Guowei, Shi; Runlin, Cai; Yuchen, Yuan; Ziying, Xie; Long, Yu; Yingjian, Huang; Qian, Shi; Lizhe, Wang; Jun, Li; Zhonghui, Tang; PROST: quantitative identification of spatially variable genes and domain detection in spatial transcriptomics, Nature Communications, 2024, 15 (600) (最后通讯作者)

(4) Xia Wu; Dan Xiong; Rong Liu; Xingqiang Lai; Yuhan Tian; Ziying Xie; Li Chen; Lanqi Hu; Jingjing Duan; Xinyu Gao; Xian Zeng; Wei Dong; Ting Xu; Fang Fu; Xin Yang; Xinlai Cheng; Dariusz Plewczynski; Minji Kim; Wenjun Xin; Tianyun Wang; Andy Peng Xiang; Zhonghui Tang; Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans, Nature Communications, 2025, 16 (2941) (最后通讯作者)

(5) Wenmin, Sun; Dan, Xiong; Jiamin, Ouyang; Xueshan, Xiao; Yi, Jiang; Yingwei, Wang; Shiqiang, Li; Ziying, Xie; Junwen, Wang; Zhonghui, Tang; Qingjiong, Zhang; Altered chromatin topologies caused by balanced chromosomal translocation lead to central iris hypoplasia, Nature Communications, 2024, 15(5048) (共同通讯作者, 排名第二)

(6) Qiao Liu; Wei Dong; Rong Liu; Luming Xu; Ling Ran; Ziying Xie; Shun Lei; Xingxing Su; Zhengliang Yue; Dan Xiong; Lisha Chen; Shuqiong Wen; Yan Zhang; Jiangjun Hu; Chenxi Qin; Yongchang Chen; Bo Zhu; Xiangyu Chen; Xia Wu; Lifan Xu; Qizhao Huang; Yingjiao Cao; Lilin Ye; Zhonghui Tang; Chromatin landscape alteration uncovers multiple transcriptional circuits during memory CD8+ T cell differentiation, Protein Cell, 2025 (最后通讯作者) 

已发表的其余论著: 

(1) Zhonghui Tang; Oscar Junhong Luo; Xingwang Li; Meizhen Zheng; Jacqueline Jufen Zhu; Przemyslaw Szalaj; Pawel Trzaskoma; Adriana Magalska; Jakub Wlodarczyk; Blazej Ruszczycki; Paul Michalski; Emaly Piecuch; Ping Wang; Danjuan Wang; Simon Zhongyuan Tian; May Penrad-Mobayed; Laurent M Sachs; Xiaoan Ruan; Chia-Lin Wei; Edison T Liu; Grzegorz M Wilczynski; Dariusz Plewczynski; Guoliang Li; Yijun Ruan; CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription, Cell, 2015, 163(7): 1611-1627(共同第一作者, 排名第一)

(2) Kyong-Rim Kieffer-Kwon; Zhonghui Tang; Ewy Mathe; Jason Qian; Myong-Hee Sung; Guoliang Li; Wolfgang Resch; Songjoon Baek; Nathanael Pruett; Lars Grøntved; Laura Vian; Steevenson Nelson; Hossein Zare; Ofir Hakim; Deepak Reyon; Arito Yamane; Hirotaka Nakahashi; Alexander L Kovalchuk; Jizhong Zou; J Keith Joung; Vittorio Sartorelli; Chia-Lin Wei; Xiaoan Ruan; Gordon L Hager; Yijun Ruan; Rafael Casellas; Interactome Maps of Mouse Gene Regulatory Domains Reveal Basic Principles of Transcriptional Regulation, Cell, 2013, 155(7): 1507-1520 (共同第一作者, 排名第二)

(3) Rongxuan Zhu; Xianglai Ye; Xiaotong Lu; Liwei Xiao; Ming Yuan; Hong Zhao; Dong Guo; Ying Meng; Hongkuan Han; Shudi Luo; Qingang Wu; Xiaoming Jiang; Jun Xu; Zhonghui Tang; Yizhi Jane Tao; Zhimin Lu; ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion, Cell Metabolism, 2025, 37(2): 361-376 (共同作者)

(4) Francesca Menghi; Floris P Barthel; Vinod Yadav; Ming Tang; Bo Ji; Zhonghui Tang; Gregory W Carter; Yijun Ruan; Ralph Scully; Roel G W Verhaak; Jos Jonkers; Edison T Liu; The tandem duplicator phenotype is a prevalent genome-wide cancer configuration driven by distinct gene mutations, Cancer Cell, 2018, 34(2):197-210 (共同作者)

(5) Laura Vian; Aleksandra Pękowska; Suhas S P Rao; Kyong-Rim Kieffer-Kwon; Seolkyoung Jung; Laura Baranello; Su-Chen Huang; Laila El Khattabi; Marei Dose; Nathanael Pruett; Adrian L Sanborn; Andres Canela; Yaakov Maman; Anna Oksanen; Wolfgang Resch; Xingwang Li; Byoungkoo Lee; Alexander L Kovalchuk; Zhonghui Tang; Steevenson Nelson; Michele Di Pierro; Ryan R Cheng; Ido Machol; Brian Glenn St Hilaire; Neva C Durand; Muhammad S Shamim; Elena K Stamenova; José N Onuchic; Yijun Ruan; Andre Nussenzweig; David Levens; Erez Lieberman Aiden; Rafael Casellas; The Energetics and Physiological Impact of Cohesin Extrusion, Cell, 2018, 173(5):1165-1178 (共同作者)

(6) Golnaz Vahedi; Yuka Kanno; Yasuko Furumoto; Kan Jiang; Stephen C. J. Parker; Michael R. Erdos; Sean R. Davis; Rahul Roychoudhuri; Nicholas P. Restifo; Massimo Gadina; Zhonghui Tang; Yijun Ruan; Francis S. Collins; Vittorio Sartorelli; John J. O Shea; Super-enhancers delineate disease-associated regulatory nodes in T cells, Nature, 2015, 520:588-562 (共同作者)

(7) Jason Qian; Qiao Wang; Marei Dose; Nathanael Pruett; Kyong-Rim Kieffer-Kwon; Wolfgang Resch; Genqing Liang; Zhonghui Tang; Ewy Mathé; Christopher Benner; Wendy Dubois; Steevenson Nelson; Laura Vian; Thiago Y Oliveira; Mila Jankovic; Ofir Hakim; Anna Gazumyan; Rushad Pavri; Parirokh Awasthi; Bin Song; Geng Liu; Longyun Chen; Shida Zhu; Lionel Feigenbaum; Louis Staudt; Cornelis Murre; Yijun Ruan; Davide F Robbiani; Qiang Pan-Hammarström; Michel C Nussenzweig; Rafael Casellas; B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity, Cell, 2014, 159(7):1524-1537 (共同作者)