个人简介

分别在福建医科大学获学士学位和硕士学位，在中山大学中山医学院(原中山医科大学)获医学博士学位。在美国NIH从事博士后研究工作和Research Fellow。中山大学“百人1期”教授级引进人才。

林贤教授长期从事中枢神经系统退行性疾病的分子发病机制研究，具有丰富的制作中枢神经退变疾病相关基因动物的技术和经验。近年来聚焦于利用精准的特异性PD动物模型进行致病基因和蛋白之间相互作用关系的研究，综合运用类脑器官、光遗传和神经回路、单细胞组学分析以及表观遗传学等多种技术手段对多巴胺神经网络系统与PD病因的关系，免疫炎症在PD发生发展中的作用进行深入研究。其研究成果已发表在世界一流的专业期刊杂志，如Neuron、Nature Neuroscience、the Journal of Neuroscience、Neurobiology of Aging、FASEB J和Human Molecular Genetics等杂志。

学术成果

代表性研究成果（部分）

(1)Zhao Li#, Jinhai Duan#, AnQi Cao#, Zhuo Gong#, Hao Liu, Danyang Shen, Tonglin Ye, Shunyan Zhu, Qikai Cen, Shuaiyin He, Yongqian He, Canbing Zheng*, and Xian Lin*. Activating Wnt1/β-Catenin signaling pathway to restore Otx2 expression in the dopaminergic neurons of ventral midbrain. Experimental Neurology. 2025 Jun:388:115216.  doi: 10.1016/j.expneurol.2025.115216

(2)Hao Liu#, Zhuo Gong#, Zhao Li#, Anqi Cao, Tonglin Ye, Shuaiying He, Jinhai Duan, Xian Lin*. Distribution, Connection and Function of ALDH1A1+/TH+ Neurons in Substantia Nigra Pars Reticulata. Neuroscience Letters, 2024 Jan 1:818:137555. doi: 10.1016/j.neulet.2023.137555.

(3)Meige Zheng#, Yanchang Liu, Zhaoming Xiao, Luyan Jiao*, Xian Lin*. Tau Knockout and α- Synuclein A53T Synergy Modulated Parvalbumin-Positive Neurons Degeneration Staging in Substantia Nigra Pars Reticulata of Parkinson's Disease-Liked Model.Frontiers in aging neuroscience, 2022 Jan; 13:1-10.

(4)Luyan Jiao#, Meige Zheng#, Jinhai Duan#, Ting Wu#, Zhao Li, Lin Liu, Xianhong Xiang, Xiaolu Tang, Jinyang He, Xingjian Li, Guofeng Zhang, Jinhui Ding, Huaibin Cai, Xian Lin*. Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related α-synuclein A53T mice. FASEB J, 2020 Sep;34(9):12239-12254.

(5)Zheng M#, Jiao L#, Tang X, Xiang X, Wan X, Yan Y, Li X, Zhang G, Li Y, Jiang B, Cai H, Lin X*. Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression. FASEB J, 2017, Aug;31(8).:3349-3358.

(6) Li X#, Zhang G, Nie Q, Wu T, Jiao L, Zheng M, Wan X, Li Y, Wu S, Jiang B, Xiang X, Duan J, Lin X*. Baicalein blocks α-synuclein secretion from SN4741 cells and facilitates α-synuclein polymerization to big complex. Neuroscience Letter, 2017, Jul 1;655:109-114.

(7) Xiaolu Tang#, Luyan Jiao, Meige Zheng, Yan Yan, Qi Nie, Ting Wu, Xiaomei Wan, Guofeng Zhang, Yonglin Li, Song Wu, Bin Jiang, Huaibin Cai, Pingyi Xu*，Jinhai Duan*and Xian Lin*. Tau deficiency down-regulated transcription factor Orthodenticle homeobox 2 expression in the dopaminergic neurons in ventral tegmental area and caused no obvious motor deficits in mice. Neuroscience，2018 Mar 1;373:52-59.

(8) Mo M, Xiao Y, Huang S, Cen L, Chen X, Zhang L, Luo Q, Li S*, Yang X*, Lin X*, Xu P*. MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian. Oncotarget, 2017, 8(1):15-28.

(9)Lin X#, Parisiadou L#, Sgobio C#, Liu GX#, Jia Yu#, Sun LX, Shim H, Gu XL, Jing Luo, Long CX, Jinhui Ding, Mateo Y, Sullivan PH, Wu LG, Goldstein DS, Lovinger D, and Cai H*.Conditional Expression of Parkinson's Disease-Related Mutant α-Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related1.The Journal of Neuroscience, 2012, 32(27):9248-9264. (2012年 Faculty of 1000推荐文章)

(10) Lin X#, Parisiadou L#, Gu XL#, Wang L#, Shim H, Sun L, Xie C, Long CX, Yang WJ, Ding J, Chen ZZ, Gallant PE, Tao-Cheng JH, Rudow G, Troncoso JC, Liu Z, Li Z, Cai H*. Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson’s Disease-related Mutant α-synuclein.Neuron, 2009, 64(6): 807-827. (当期重点评论的文章)

(11) Parisiadou L#*, Yu J#, Sgobio C#, Xie C, Liu G, Sun L, Gu XL, Lin X, Crowley NA, Lovinger DM, Cai H*. LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Nat Neurosci, 2014, 17(3):367-76.

(12).Chen Lai#, Xian Lin#, Jayanth Chandran, et al. The G59S mutation in p150glued causes dysfunction in mice. The Journal of Neuroscience,2007, 27(51):13982-13900. 

(并列第一作者)

(13).Xian Lin#, Hoon Shim, Huaibin Cai. Deficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1(G93A) transgenic mice. Neurobiol Aging，

2007 Oct; 28(10):1628-30.

学术兼职

美国神经科学学会会员，中国生物物理学会神经科学分会委员，中国神经科学学会会员，中国解剖学会会员。

科研项目

主持多项国家级、省级和市级科研项目。

常年招收博后，欢迎对神经退变疾病的发病机制研究感兴趣的同学联系。