个人简介

董俊超先后获得复旦大学生命科学院学士、得克萨斯大学圣安东尼奥健康科学中心博士学位，并在哈佛医学院从事博士后研究。获得国家高层次引进人才青年项目、广东省珠江人才计划创新创业团队和中山大学等项目支持，2017年起任中山大学中山医学院教授，专注于B淋巴细胞的发育、成熟和病变，重点以多组学方法研究表观调控和三维基因组结构影响淋巴细胞发育及血液系统肿瘤发生的机制，并探索肿瘤免疫治疗新疗法。相关研究成果发表在Nature、Molecular Cell、 EMBO J.、 PNAS、Cell Reports、J. Leukocyte. Biol.等学术期刊。

学术成果

1. Yang, Y Guo, L Liu, T Huang, B Zhao, W Bai, G Zhang, C Zhu, J Dong#，The LIM-domain-only protein LMO2 and its binding partner LDB1 are differentially required for class switch recombination. Proceedings of the National Academy of Sciences2025 Jan 28;122(4):e2412376122

2. Du L, Oksenych V, Wan H, Ye X, Dong J, Ye AY, Abolhassani H, Vlachiotis S, Zhang X, de la Rosa K, Hammarström L, van der Burg M, Alt FW, Pan-Hammarström Q. Orientation Regulation of Class-switch Recombination in Human B Cells. J Immunol.2024 Oct 15;213(8):1093-1104. 

3. Liu Y, Ye SY, He S, Chi DM, Wang XZ, Wen YF, Ma D, Nie RC, Xiang P, Zhou Y, Ruan ZH, Peng RJ, Luo CL, Wei PP, Lin GW, Zheng J, Cui Q, Cai MY, Yun JP, Dong J, Mai HQ, Xia X, Bei JX. Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma. Nature Communications2024 Sep 4;15(1):7713

4. Zhao B, Xia Z, Yang B, Guo Y, Zhou R, Gu M, Liu M, Li Q, Bai W, Huang J, Zhang X, Zhu C, Leung KT, Chen C, Dong J#. USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation. Cell Rep. 2024 May 28;43(5):114194. 

5.Huang ME, Qin Y, Shang Y, Hao Q, Zhan C, Lian C, Luo S, Liu LD, Zhang S, Zhang Y, Wo Y, Li N, Wu S, Gui T, Wang B, Luo Y, Cai Y, Liu X, Xu Z, Dai P, Li S, Zhang L, Dong J, Wang J, Zheng X, Xu Y, Sun Y, Wu W, Yeap LS, Meng FL. C-to-G editing generates double-strand breaks causing deletion, transversion and translocation. Nat Cell Biol. 2024 Feb;26(2):294-304. 

6. C Li, L Wen, J Dong, L Li, J Huang, J Yang, T Liang, T Li, Z Xia, C Chen. Alterations in cellular metabolisms after TKI therapy for Philadelphia chromosome-positive leukemia in children. Frontiers in Oncology. 2022 Dec 6:12:1072806.12, 1072806

7. Bai W, Zhao B, Gu M, Dong J#. Alternative end-joining in BCR gene rearrangements and translocations. Acta Biochim Biophys Sin . 2022 May 25;54(6):782-795. 

8. Wanyu Bai,  Guangchao Zhu, Jiejie Xu,  Pingyue Chen,  Feilong Meng, Hongman Xue, Chun Chen# and Junchao Dong#. 3’-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching. Cell Reports. In press.

9. X Sun, M Liu, J Bai, J Xu, C Zhu, J Dong#, C Chen#.  ATR kinase activity promotes antibody class switch recombination in B cells through cell cycle regulation without suppressing DSB resection and microhomology usage. J. Leukoc Biol. 2021 Apr 22

10. Sun X, Bai J, Xu J, Xi X, Gu M, Zhu C, Xue H, Chen C, Dong J#. Multiple DSB Resection Activities Redundantly Promote Alternative End Joining-Mediated Class Switch Recombination. Front Cell Dev Biol. 2021 Nov 26;9:767624. 

11. Dingpeng Yang, Ying Sun, Jingjing Chen, Ying Zhang, et al.,  REV7 is required for processing AID initiated DNA lesions in activated B cells. Nature Communications. 2020(1):1-11

12. Xiaojing Liu, Tingting Liu, Yafang Shang, Pengfei Dai, Wubing Zhang, et al., ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells. Cell Research, 2020:1-13

13. Guoxing Zheng, Qingqing Zhu, Junchao Dong, Xin Lin, Chengming Zhu. Rapid generation and selection of Cas9-engineering TRP53 R172P mice that do not have off-target effects. BMC Biotechnology. 2019

14. Juan He, Qiong Yang, Qiang Xiao, Aihua Lei, Xing Li, Pan Zhou, Ting Liu, Lijuan Zhang, Kun Shi, Quan Yang, Junchao Dong, Jie Zhou. IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation. Cell reports 2019: 29 (9), 2718-2730 

15. Panchakshari RA, Zhang X, Kumar V, Du Z, Wei PC, Kao J, Dong J#, Alt FW#. DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions. Proc Natl Acad Sci 2018 Jan 23;115(4):762-767. (*共同通讯作者)

16. Nguyen HV, Dong J, Panchakshari RA, Kumar V, Alt FW, Bories JC. Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination. Proc Natl Acad Sci. 2017 Dec 5;114(49)

17. Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW, Frock RL. Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nat Protoc. 2016 May;11(5):853-71

18.  Dong J#, Panchakshari RA#, Zhang T#, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW. Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature. 2015 Sep 3;525(7567):134-9 (#co-first author)

19. Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW. gH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proc Natl Acad Sci. 2014 Feb 18;111(7):2644-9

20. Li F*, Dong J*, Eichmiller R, Holland C, Minca E, Prakash R, Sung P, Shim E, Surtees JA, Eun Lee S. Role of Saw1 in Rad1/Rad10 complex assembly at recombination intermediates in budding yeast. EMBO J. 2013 Feb 6;32(3):461-72 (#co-first author)

21. Toh GW*, Sugawara N*, Dong J*, Toth R, Lee SE, Haber JE, Rouse J.Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1/Rad10 dependent cleavage of non-homologous DNA tails. DNA Repair (Amst). 2010 Jun 4;9(6):718-2 (#co-first author)

22. Li F*, Dong J*, Pan X, Oum JH, Boeke JD, Lee SE. Microarray- based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of recombination intermediates. Mol.Cell 2008 May 9;30(3):325-35 (#co-first author)

科研项目

基金项目：
1.广州市科技计划基础与应用基础项目 (202002030064) 2020.1-2021.12，主持

2.教育部青年教师重点培育项目2019.1-2020.12，主持

3.国家自然科学基金委员会面上项目（32270934）,2023.01-2026.12主持

4. 国家自然科学基金委员会面上项目（81871304） 2019.01-2022.12主持5.国家自然科学基金委员会面上项目 (32070892) 2021.1月-2024.12, 主持6.中山大学百人计划 2017-2020，主持

7. 广东省消化系统恶性肿瘤防治研究重点实验室开放基(2021B1212040006)，主持

8. 深圳市三名工程儿童血液肿瘤团队项目（SZSM202011004）2020.1-2024.12，骨干

9.广东省科技厅“珠江人才计划”引进创新创业团队 临床免疫学精准诊疗转化医学创新团队项目2017-2021，骨干10.国家重点研发计划骨干，人齿龈间充质干细胞治疗自身免疫性炎症性疾病，骨干

获奖荣誉

2016 入选中山大学第二批“百人计划”
2016 入选国家高层次引进人才青年项目
2017 入选广东省“珠江人才计划”引进创新创业团队
2017 科技部重点研发项目骨干

学术兼职

中国免疫学会基础免疫学分会

广东省免疫学会青年委员会

广东省精准医学应用学会

为以下学术期刊特邀审稿人：Nature Communications, Science Advances, Science Signaling, Cancer Letters, Molecular and Cellular Biology, International Journal of Biological Sciences, PLOS One, Mutation Research等。