个人简介

任中国实验动物学会“实验动物资源鉴定与评价评审专家”，中国医药生物技术协会科研实验室建设与管理分会第二届委员会委员，广东省医学会细胞治疗学分会青年委员会委员，干细胞与再生医学国家地方联合工程研究中心、干细胞与组织工程教育部重点实验室研究人员，广东省生殖医学重点实验室研究人员。主要研究成果包括：利用基因编辑技术建立多种人类遗传疾病灵长类动物模型，包括MCPH1基因缺失小脑症食蟹猴模型、FAH基因缺失酪氨酸血症I型食蟹猴模型及SHANK3基因缺失自闭症食蟹猴模型等，首次证实利用TALEN技术可以获得具有显著表型的食蟹猴模型；建立了多种转基因小鼠及人类的正常和疾病多能干细胞系；首次证实CX43、CX45能促进细胞重编程效率，为提高iPSCs的形成效率及探讨细胞重编程机制提供重要的理论基础等。以第一作者及通讯作者在Nature、Cell Research、Cell Discovery等杂志发表论文多篇，主持参与国家重点研发项目、国家自然科学基金项目、省重点领域研发计划项目及广州市健康医疗协同创新重大专项等基金项目。

学术成果

1. Zhu, J#., Lan, X., Mo, K., Zhang, W., Huang, Y., Tan, J., Wang, L., Ji,J.,  Ke, Q*., Ouyang,H*.(2024) Deficiency of SECTM1 impairs corneal wound healing in aging. Aging Cell. 2024;00:e14247.
2. Li, F#., Lai, J#., Ma, F#., Cai, Y., Li, S., Feng, Z., Lu, Z,. Liu, X., Ke, Q*., Hao, H*., Xiao*, X*. (2023). Maternal melatonin supplementation shapes gut microbiota and protects against inflammation in early life. International Immunopharmacology, 120, July, 110359
3. Liang, C#., Ke, Q#., Liu, Z#., Ren, J#., Zhang, W#., Hu, J., Wang, Z., Chen, H., Xia, K., Lai, X., Wang, Q., Yang, K., Li, W., Wu, Z., Wang, C., Yan, H., Jiang, X., Ji, Z., Ma, M., Long, X., Wang, S., Wang, H., Sun, H., Belmonte, J., QU, J*., Xiang, A. P*. & Liu, G. H*. (2022), "BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates", Nucleic Acids Res, Vol. 50 No. 6, pp. 3323-3347.
4. Chen, H#., Xia, K#., Huang, W#., Li, H., Wang, C., Ma, Y., Chen, J., Luo, P., Zheng, S., Wang, J., Wang, Y., Dong, L., Tan, Z., Lai, X., Mao, F. F., Li, W., Liang, X., Wang, T., Xiang, A. P., & Ke, Q*. (2021). Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates. Cell Discovery, 7(1).
5. Feng, X#., Xia, K#., Ke, Q#., Deng, R., Zhuang, J., Wan, Z., Luo, P., Wang, F., Zang, Z., Sun, X., Xiang, A.P., Tu, X*., Gao, Y., & Deng, C.* (2020). Transplantation of encapsulated human Leydig-like cells: A novel option for the treatment of testosterone deficiency. Molecular and Cellular Endocrinology, 519: 111039.
6. Xia, K#., Chen, H#. , Wang, J#., Feng, X#., Gao, Y., Wang, Y., Deng, R., Wu, C., Luo, P., Zhang, M., Wang, C., Zhang, Y., Zhang, Y., Liu, G., Tu, X., Sun, X., Li, W., Ke, Q*., Deng, C*. and Xiang, A.P*., (2020). Restorative functions of Autologous Stem Leydig Cell transplantation in a Testosterone-deficient non-human primate model. Theranostics, 10 (19):8705-8720. 
7. Zhou, Y#., Sharma, J#., Ke, Q#., Landman, R#., Yuan, J., Chen, H., Hayden, D. S., Fisher, J. W., Jiang, M., Menegas, W., Aida, T., Yan, T., Zou, Y., Xu, D., Parmar, S., Hyman, J. B., Fanucci-Kiss, A., Meisner, O., Wang, D., Huang, Y., Li, Y., Bai, Y., Ji, W., Lai, X., Li, W., Huang, L., Lu, Z., Wang, L., Anteraper, S. A., Sur, M., Zhou, H*., Xiang, A. P*., Desimone, R., Feng, G*., & Yang, S*. (2019). Atypical behaviour and connectivity in SHANK3-mutant macaques. Nature, 570, 326-331. 
8. Ke, Q#., Li, L#., Yao, X#., Lai, X., Cai, B., Chen, H., Chen, R., Zhai, Z., Huang, L., Li, K., Hu, A., Mao, F. F., Xiang, A. P., Tao, L*., & Li, W*. (2017). Enhanced generation of human induced pluripotent stem cells by ectopic expression of Connexin 45. Scientific Reports, 7, 458.
9. Ma, Y#., Li, J#., Wang, G#., Ke, Q#., Qiu, S., Gao, L., Wan, H., Zhou, Y., Xiang, A. P., Huang, Q., Feng, G*., Zhou, Q*., & Yang, S*. (2016). Efficient production of cynomolgus monkeys with a toolbox of enhanced assisted reproductive technologies. Scientific Reports, 6, 25888.
10. Ke, Q#., Li, W#., Lai, X#., Chen, H., Huang, L., Kang, Z., Li, K., Ren, J., Lin, X., Zheng, H., Huang, W., Ma, Y., Xu, D., Chen, Z., Song, X., Lin, X., Zhuang, M., Wang, T., Zhuang, F., Xi, J., Mao, F. F., Xia, H., Lahn, B. T., Zhou, Q*., Yang, S*., & Xiang, A. P*. (2016). TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Cell Research, 26, 1048-1061.
11. Ke, Q#., Li, L#., Cai, B#., Liu, C., Yang, Y., Gao, Y., Huang, W., Yuan, X., Wang, T., Zhang, Q., Harris, A. L., Tao, L., & Xiang, A. P*. (2013). Connexin 43 is involved in the generation of human-induced pluripotent stem cells. Human Molecular Genetics, 22, 2221-2233.
12. Cheng, F#., Ke, Q#., Chen, F#., Cai, B., Gao, Y., Ye, C., Wang, D., Zhang, L., Lahn, B. T., Li, W*., & Xiang, A. P*. (2012). Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials, 33, 3195-3204.
13. 酪氨酸血症I型猴模型及其建立方法和应用，授权专利号；ZL201910399416.8；发明人：项鹏、柯琼、赖兴强、陈洪、李伟强、毛富祥
14. 猴卵巢滤泡膜干细胞及其分离方法、培养方法和应用，授权专利号；ZL202010214438.5；发明人：项鹏、柯琼、陈洪、李伟强
15. 人睾丸间质干细胞的分离与培养方法，授权专利号；ZL202010113071.8；发明人：项鹏、邓春华、夏凯、柯琼

科研项目

1. 国家自然科学基金面上项目82471689（2025.01-2028.12）项目负责人，48万，在研
2. 国家自然科学基金面上项目82171617（2022.01-2025.12）项目负责人，53万，在研
3. 国家重点研发计划项目2022YFA 1104100（2022.11-2027.10）课题骨干，242.76万/2800万，在研
4. 广东省重点领域研发计划项目2019B020235002（2019.01-2021.12）项目负责人，300万，已结题
5. 国家重点研发计划项目2018YFA0801404（2019.11-2024.10）课题骨干，300.38万/7050万，在研
6. 国家重点研发计划项目2018YFA0107200（2018.07-2023.12）课题骨干，300万/2932万，已结题
7. 广东省科技计划重大专项2017B020231001（2017.09-2020.08）课题骨干，100万/1000万，已结题
8. 中山大学重大项目培育和新兴、交叉学科资助计划项目15ykjc01c（2015.10-2017.10）项目负责人，15万，已结题
9. 广东省科技计划重大专项2014B020225007（2015.01-2017.12）参与人，125万/500万，已结题
10. 国自然青年科学基金项目 31301219（2014.01-2016.12）项目负责人，21万，已结题
11. 教育部博士点基金项目20130171120061（2014.01-2016.12）项目负责人，4万，已结题